ID   RASEF_XENTR             Reviewed;         722 AA.
AC   Q08CX1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Ras and EF-hand domain-containing protein;
GN   Name=rasef;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds predominantly GDP, and also GTP.
CC       {ECO:0000250|UniProtKB:Q8IZ41}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q8IZ41}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:Q8IZ41}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC124049; AAI24050.1; -; mRNA.
DR   RefSeq; NP_001072877.1; NM_001079409.1.
DR   AlphaFoldDB; Q08CX1; -.
DR   SMR; Q08CX1; -.
DR   STRING; 8364.ENSXETP00000036560; -.
DR   PaxDb; Q08CX1; -.
DR   Ensembl; ENSXETT00000036560; ENSXETP00000036560; ENSXETG00000016758.
DR   GeneID; 780339; -.
DR   KEGG; xtr:780339; -.
DR   CTD; 158158; -.
DR   Xenbase; XB-GENE-1002559; rasef.
DR   eggNOG; KOG0078; Eukaryota.
DR   HOGENOM; CLU_023178_1_0_1; -.
DR   InParanoid; Q08CX1; -.
DR   OMA; PKFTGHS; -.
DR   OrthoDB; 1184845at2759; -.
DR   PhylomeDB; Q08CX1; -.
DR   TreeFam; TF313106; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016758; Expressed in brain and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; GTP-binding; Nucleotide-binding;
KW   Reference proteome; Repeat.
FT   CHAIN           1..722
FT                   /note="Ras and EF-hand domain-containing protein"
FT                   /id="PRO_0000299580"
FT   DOMAIN          5..39
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          39..74
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          75..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          355..384
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..491
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          156..335
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        355..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..491
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         532..537
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZ41"
FT   BINDING         635..638
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZ41"
FT   BINDING         672..673
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IZ41"
SQ   SEQUENCE   722 AA;  81821 MW;  286013A57B8C688C CRC64;
     MEDKDELSRL RALFHTFDSK SSGRLEKGQF SALCAELKVS PSEAEDIFAR LDSDKDSCIT
     FEDFAMGFRG ARGLHMPEGK KDVEQGEPPK SPSTPDKEEK PEETSSPAWE DFQRRLADEV
     NYIPRREQAS ILYQNINIVE PLLIQQYEHV IRNFVREIRL QSTEMENLAI AVKRAQDKAA
     IQLSELEEEM DQRIQAVEKR VKKEEKRKSE EALNDLKRQH ESEVAELQVT IKKLKKLEEQ
     SKNINLKEDV AVLRRRLHDL TMENQKLRKD LLEAQTSISF LQSELDALKS DYADQSLSSE
     RDMDIIRGFT DERENLARQI EILQTANRKL HDSNDGLRSA LENSLMKYNR SLRTINTSPG
     STISRNSPKL TRCTSPYDRS PRSSYLDEDY DSLAVCDPMQ RMNCEVDSLP ESCIDSGLST
     LRDSNEYDSE AEYRPPRIFH RSRFPHENYG GDASDTDVPE IRDEESYAPD NGGNLDWKPS
     NPVSRSSSGA SSSRKCISAL SANVTSAETV DKVHKYTHAE KAYKIVLAGD AAVGKSSFLM
     RLCKNEFRGN TSATLGVDFQ MKTLVVDGEP TILQLWDTAG QERFRSIAKS YFRRADGVLL
     LYDVTCEKSF LNVREWIDMI EDATSEAIPI MMVGNKADLR QLMAEQGHIC VSTNYGEKLS
     RTYGALFCET SAKEGSNIVE AVLHLAREVR KRCDNEDDRG SVTNLSAAIS KKPAQMKNCC
     NV