ID   RASF2_RAT               Reviewed;         326 AA.
AC   Q3B7D5;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Ras association domain-containing protein 2;
GN   Name=Rassf2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Potential tumor suppressor. Acts as a KRAS-specific effector
CC       protein. May promote apoptosis and cell cycle arrest. Stabilizes
CC       STK3/MST2 by protecting it from proteasomal degradation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts directly with activated KRAS in a GTP-dependent
CC       manner. Interacts (via SARAH domain) with STK3/MST2 AND STK4/MST1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50749}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P50749}. Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:P50749}. Note=Translocates to the cytoplasm in
CC       the presence of STK3/MST2 AND STK4/MST1.
CC       {ECO:0000250|UniProtKB:P50749}.
CC   -!- PTM: Phosphorylated by STK3/MST2 and STK4/MST1. {ECO:0000250}.
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DR   EMBL; BC107656; AAI07657.1; -; mRNA.
DR   RefSeq; NP_001032173.1; NM_001037096.1.
DR   AlphaFoldDB; Q3B7D5; -.
DR   SMR; Q3B7D5; -.
DR   STRING; 10116.ENSRNOP00000028883; -.
DR   PaxDb; Q3B7D5; -.
DR   PRIDE; Q3B7D5; -.
DR   GeneID; 311437; -.
DR   KEGG; rno:311437; -.
DR   UCSC; RGD:1305551; rat.
DR   CTD; 9770; -.
DR   RGD; 1305551; Rassf2.
DR   eggNOG; KOG4239; Eukaryota.
DR   InParanoid; Q3B7D5; -.
DR   PhylomeDB; Q3B7D5; -.
DR   PRO; PR:Q3B7D5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0004672; F:protein kinase activity; ISO:RGD.
DR   GO; GO:0046849; P:bone remodeling; ISO:RGD.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0038168; P:epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade; ISO:RGD.
DR   GO; GO:0048872; P:homeostasis of number of cells; ISO:RGD.
DR   GO; GO:1901223; P:negative regulation of NIK/NF-kappaB signaling; ISO:RGD.
DR   GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; ISO:RGD.
DR   GO; GO:0001503; P:ossification; ISO:RGD.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
DR   GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISO:RGD.
DR   GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:RGD.
DR   GO; GO:0050821; P:protein stabilization; ISO:RGD.
DR   GO; GO:1901222; P:regulation of NIK/NF-kappaB signaling; ISO:RGD.
DR   GO; GO:0045667; P:regulation of osteoblast differentiation; ISO:RGD.
DR   GO; GO:0045670; P:regulation of osteoclast differentiation; ISO:RGD.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   GO; GO:0001501; P:skeletal system development; ISO:RGD.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033614; RASSF1-6.
DR   InterPro; IPR033618; RASSF2.
DR   InterPro; IPR011524; SARAH_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR22738; PTHR22738; 1.
DR   PANTHER; PTHR22738:SF14; PTHR22738:SF14; 1.
DR   Pfam; PF16517; Nore1-SARAH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50951; SARAH; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Centromere; Chromosome; Cytoplasm; Kinetochore; Nucleus;
KW   Phosphoprotein; Reference proteome; Tumor suppressor.
FT   CHAIN           1..326
FT                   /note="Ras association domain-containing protein 2"
FT                   /id="PRO_0000233039"
FT   DOMAIN          176..264
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          272..319
FT                   /note="SARAH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00310"
SQ   SEQUENCE   326 AA;  38021 MW;  33B63CD93F25C5F1 CRC64;
     MDYTHQTALI PCGQDKYMPK SELLLHLKTY NLYYEGQNLQ LRHREEEDEF IVEGLLNISW
     GLRRPIRLQM QDDHERIRPP PSSSSWHSGC NLGAQGTTLK PLTVPTVQIS EVDMPVENME
     MHSPTDSRGL KPVQEDTPQL MRTRSDVGVR RRGNVRTSSD QRRIRRHRFS INGHFYNHKT
     SVFTPAYGSV TNVRINSTMT TPQVLKLLLN KFKIENSAEE FALYVVHTSG EKQKLKNSDY
     PLIARILQGP CEQISKVFLM EKDQVEEVTY DVAQYIKFEM PVLKSFIQKL QEEEDREVEK
     LMQKYTVLRL MIRQRLEEIA ETPETI