RASF3_MOUSE
ID RASF3_MOUSE Reviewed; 232 AA.
AC Q99P51; Q3TJ17;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Ras association domain-containing protein 3;
GN Name=Rassf3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=11965544; DOI=10.1038/sj.onc.1205365;
RA Tommasi S., Dammann R., Jin S.-G., Zhang X.-F., Avruch J., Pfeifer G.P.;
RT "RASSF3 and NORE1: identification and cloning of two human homologues of
RT the putative tumor suppressor gene RASSF1.";
RL Oncogene 21:2713-2720(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Note=Localized to microtubules in vascular endothelial
CC cells. {ECO:0000250}.
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DR EMBL; AF332864; AAK06849.1; -; mRNA.
DR EMBL; AK155495; BAE33293.1; -; mRNA.
DR EMBL; AK167627; BAE39678.1; -; mRNA.
DR EMBL; BC011511; AAH11511.1; -; mRNA.
DR EMBL; BC055023; AAH55023.1; -; mRNA.
DR EMBL; BC071204; AAH71204.1; -; mRNA.
DR CCDS; CCDS24211.1; -.
DR RefSeq; NP_620406.1; NM_138956.3.
DR AlphaFoldDB; Q99P51; -.
DR SMR; Q99P51; -.
DR STRING; 10090.ENSMUSP00000026902; -.
DR iPTMnet; Q99P51; -.
DR PhosphoSitePlus; Q99P51; -.
DR EPD; Q99P51; -.
DR MaxQB; Q99P51; -.
DR PaxDb; Q99P51; -.
DR PRIDE; Q99P51; -.
DR ProteomicsDB; 300355; -.
DR Antibodypedia; 29184; 197 antibodies from 32 providers.
DR DNASU; 192678; -.
DR Ensembl; ENSMUST00000026902; ENSMUSP00000026902; ENSMUSG00000025795.
DR GeneID; 192678; -.
DR KEGG; mmu:192678; -.
DR UCSC; uc007hfs.1; mouse.
DR CTD; 283349; -.
DR MGI; MGI:2179722; Rassf3.
DR VEuPathDB; HostDB:ENSMUSG00000025795; -.
DR eggNOG; KOG4239; Eukaryota.
DR GeneTree; ENSGT00940000157502; -.
DR HOGENOM; CLU_045544_1_0_1; -.
DR InParanoid; Q99P51; -.
DR OMA; SQSQGRC; -.
DR OrthoDB; 1120975at2759; -.
DR PhylomeDB; Q99P51; -.
DR TreeFam; TF319243; -.
DR BioGRID-ORCS; 192678; 1 hit in 70 CRISPR screens.
DR ChiTaRS; Rassf3; mouse.
DR PRO; PR:Q99P51; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q99P51; protein.
DR Bgee; ENSMUSG00000025795; Expressed in ascending aorta and 214 other tissues.
DR Genevisible; Q99P51; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033614; RASSF1-6.
DR InterPro; IPR033619; RASSF3.
DR InterPro; IPR011524; SARAH_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22738; PTHR22738; 1.
DR PANTHER; PTHR22738:SF8; PTHR22738:SF8; 1.
DR Pfam; PF16517; Nore1-SARAH; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50951; SARAH; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q86WH2"
FT CHAIN 2..232
FT /note="Ras association domain-containing protein 3"
FT /id="PRO_0000240397"
FT DOMAIN 78..180
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT DOMAIN 181..228
FT /note="SARAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00310"
FT REGION 25..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q86WH2"
FT CONFLICT 113
FT /note="N -> D (in Ref. 2; BAE39678)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 232 AA; 26749 MW; EA3E671259412CA2 CRC64;
MSSGYSSLEE DEDFFFTART SFFRRAPPGK SRSGQPDVEK EKETHNYLSK EEIKEKVHKY
NSAVTDKLKM TLNSNGIYTG FIKVQMELCK PAQPSPEPSS GGCMNTLHIS STNTVGEVIE
ALLRKFLVTE SPTKFALYKR CHREDQVYAC KLSDREHPLY LRLVAGPRTD TLSFVLREHE
IGEWEAFSLP ELQNFLRILD KEEDEQLQSL KRRYTAYRQK LEEALGEVWK PG
