ID   RASF4_RAT               Reviewed;         322 AA.
AC   Q566C5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Ras association domain-containing protein 4;
GN   Name=Rassf4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Potential tumor suppressor. May act as a KRAS effector
CC       protein. May promote apoptosis and cell cycle arrest (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts directly with activated KRAS in a GTP-dependent
CC       manner. {ECO:0000250}.
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DR   EMBL; BC093620; AAH93620.1; -; mRNA.
DR   RefSeq; NP_001019446.1; NM_001024275.1.
DR   RefSeq; XP_017448190.1; XM_017592701.1.
DR   AlphaFoldDB; Q566C5; -.
DR   STRING; 10116.ENSRNOP00000018101; -.
DR   PaxDb; Q566C5; -.
DR   Ensembl; ENSRNOT00000018101; ENSRNOP00000018101; ENSRNOG00000013526.
DR   GeneID; 362423; -.
DR   KEGG; rno:362423; -.
DR   UCSC; RGD:1307785; rat.
DR   CTD; 83937; -.
DR   RGD; 1307785; Rassf4.
DR   eggNOG; KOG4239; Eukaryota.
DR   GeneTree; ENSGT00940000160176; -.
DR   HOGENOM; CLU_018893_1_0_1; -.
DR   InParanoid; Q566C5; -.
DR   OMA; HAPGEAQ; -.
DR   OrthoDB; 1043350at2759; -.
DR   PhylomeDB; Q566C5; -.
DR   TreeFam; TF319243; -.
DR   PRO; PR:Q566C5; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000013526; Expressed in lung and 20 other tissues.
DR   Genevisible; Q566C5; RN.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033614; RASSF1-6.
DR   InterPro; IPR033622; RASSF4.
DR   InterPro; IPR011524; SARAH_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR22738; PTHR22738; 1.
DR   PANTHER; PTHR22738:SF4; PTHR22738:SF4; 1.
DR   Pfam; PF16517; Nore1-SARAH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50951; SARAH; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Phosphoprotein; Reference proteome; Tumor suppressor.
FT   CHAIN           1..322
FT                   /note="Ras association domain-containing protein 4"
FT                   /id="PRO_0000240400"
FT   DOMAIN          175..263
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          271..318
FT                   /note="SARAH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00310"
FT   REGION          96..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..118
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..138
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8CB96"
SQ   SEQUENCE   322 AA;  37125 MW;  0C23FEE5604BEFC9 CRC64;
     MKEDCSPSSH VPISDSKFIL KSELLSLLKT YNCYHEGRSF QLRHREEEGT LIIEGLLNIA
     WGLRRPIRLQ MQDDRERVHL PSATWVPERL SYLQKDASPQ DSKVPAEEPS TQPANKGEVS
     RDGSGPLQEE EEEVPQLMRT KSDASCIIQR RCKSRAPGEA QKIRRHRFSI NGHFYNHKTS
     VFTPAYGSVT NVRVNSTMTT QQVLTLLLNK FRVEDGPSEF ALYTVHESGE QTKLKDCEYP
     LISRILHGPC EKIVKIFLME ADLSEEVPHD VAQYIKFEMP VLDSFVEKLK EEEEREIIKL
     TMKFQALRLT MQQRLEQLVE AK