ID   RASF6_RAT               Reviewed;         341 AA.
AC   Q4QR82;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Ras association domain-containing protein 6;
GN   Name=Rassf6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in the induction of apoptosis. May act as a Ras
CC       effector protein. May suppress the serum-induced basal levels of NF-
CC       kappa-B.
CC   -!- SUBUNIT: Interacts with MOAP1. Interaction with activated KRAS is still
CC       a matter of debate. {ECO:0000250}.
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DR   EMBL; BC097375; AAH97375.1; -; mRNA.
DR   RefSeq; NP_001020842.1; NM_001025671.1.
DR   RefSeq; XP_006250807.1; XM_006250745.3.
DR   RefSeq; XP_006250809.1; XM_006250747.3.
DR   RefSeq; XP_006250810.1; XM_006250748.1.
DR   RefSeq; XP_008768259.1; XM_008770037.2.
DR   RefSeq; XP_008768260.1; XM_008770038.2.
DR   AlphaFoldDB; Q4QR82; -.
DR   SMR; Q4QR82; -.
DR   BioGRID; 258112; 1.
DR   STRING; 10116.ENSRNOP00000003836; -.
DR   PaxDb; Q4QR82; -.
DR   PRIDE; Q4QR82; -.
DR   Ensembl; ENSRNOT00000003836; ENSRNOP00000003836; ENSRNOG00000002866.
DR   GeneID; 305251; -.
DR   KEGG; rno:305251; -.
DR   UCSC; RGD:1566082; rat.
DR   CTD; 166824; -.
DR   RGD; 1566082; Rassf6.
DR   eggNOG; KOG4239; Eukaryota.
DR   GeneTree; ENSGT00940000159886; -.
DR   HOGENOM; CLU_018893_0_0_1; -.
DR   InParanoid; Q4QR82; -.
DR   OMA; WIFVNER; -.
DR   OrthoDB; 1043350at2759; -.
DR   PhylomeDB; Q4QR82; -.
DR   TreeFam; TF319243; -.
DR   PRO; PR:Q4QR82; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000002866; Expressed in colon and 13 other tissues.
DR   Genevisible; Q4QR82; RN.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:RGD.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033614; RASSF1-6.
DR   InterPro; IPR033625; RASSF6.
DR   InterPro; IPR011524; SARAH_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR22738; PTHR22738; 1.
DR   PANTHER; PTHR22738:SF3; PTHR22738:SF3; 1.
DR   Pfam; PF16517; Nore1-SARAH; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50951; SARAH; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Phosphoprotein; Reference proteome.
FT   CHAIN           1..341
FT                   /note="Ras association domain-containing protein 6"
FT                   /id="PRO_0000240406"
FT   DOMAIN          190..278
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   DOMAIN          285..332
FT                   /note="SARAH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00310"
FT   MOD_RES         155
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q80UQ2"
SQ   SEQUENCE   341 AA;  39794 MW;  B0F3634F29C7092E CRC64;
     MTTMDHRFPS RIFVNERTSI TREQLNSLLE TYNVFYENQK NLHILYGQTE DGQLIVEGML
     DIFWGVKRPI QLKIQDEKQI SSFDLLKSPE TFSSKGRMTR WGEFDDLYRI SEMDKTQALA
     PEARHTPEDY LSCYSVLKQC ADEEPESPLL YRTVSEAALV RKRMRAPEMY RKDRMGTLAK
     HRASINGHVY DHETSIFTPT FGSETKVRAN SIMKTEEVIK QLLQKFKIEN SPRDFALYII
     FGTGEKRKLK KTDVPLLQRL IQGPSKSNAR IFLMDKDAEE ISSDVAPYIN FHFSFLKSIL
     QRLDEEEKME IERIMAKFNT ERAFILKCLQ SKRAAKTETT V