RASF8_MOUSE
ID RASF8_MOUSE Reviewed; 419 AA.
AC Q8CJ96; Q149Q5; Q8CCW4; Q9CU91;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ras association domain-containing protein 8;
DE AltName: Full=Carcinoma-associated protein HOJ-1 homolog;
GN Name=Rassf8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Wang M., Futamura M., Zhang Z., Wang Y., You M.;
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 173-419.
RC STRAIN=C57BL/6J; TISSUE=Intestine, and Medulla oblongata;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
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DR EMBL; AF424737; AAN28310.1; -; mRNA.
DR EMBL; BC115779; AAI15780.1; -; mRNA.
DR EMBL; BC117546; AAI17547.1; -; mRNA.
DR EMBL; AK017214; BAB30637.1; -; mRNA.
DR EMBL; AK031980; BAC27637.1; -; mRNA.
DR CCDS; CCDS20696.1; -.
DR RefSeq; NP_082036.1; NM_027760.2.
DR RefSeq; XP_011239900.1; XM_011241598.1.
DR RefSeq; XP_011239901.1; XM_011241599.1.
DR RefSeq; XP_011239902.1; XM_011241600.2.
DR AlphaFoldDB; Q8CJ96; -.
DR SMR; Q8CJ96; -.
DR BioGRID; 214636; 2.
DR STRING; 10090.ENSMUSP00000107333; -.
DR iPTMnet; Q8CJ96; -.
DR PhosphoSitePlus; Q8CJ96; -.
DR MaxQB; Q8CJ96; -.
DR PaxDb; Q8CJ96; -.
DR PeptideAtlas; Q8CJ96; -.
DR PRIDE; Q8CJ96; -.
DR ProteomicsDB; 253174; -.
DR Antibodypedia; 24278; 367 antibodies from 32 providers.
DR DNASU; 71323; -.
DR Ensembl; ENSMUST00000032388; ENSMUSP00000032388; ENSMUSG00000030259.
DR Ensembl; ENSMUST00000111704; ENSMUSP00000107333; ENSMUSG00000030259.
DR GeneID; 71323; -.
DR KEGG; mmu:71323; -.
DR UCSC; uc009err.1; mouse.
DR CTD; 11228; -.
DR MGI; MGI:1918573; Rassf8.
DR VEuPathDB; HostDB:ENSMUSG00000030259; -.
DR eggNOG; KOG1574; Eukaryota.
DR GeneTree; ENSGT00950000182839; -.
DR HOGENOM; CLU_031151_0_0_1; -.
DR InParanoid; Q8CJ96; -.
DR OMA; VEIRYWE; -.
DR OrthoDB; 1442074at2759; -.
DR PhylomeDB; Q8CJ96; -.
DR TreeFam; TF318385; -.
DR BioGRID-ORCS; 71323; 3 hits in 73 CRISPR screens.
DR PRO; PR:Q8CJ96; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8CJ96; protein.
DR Bgee; ENSMUSG00000030259; Expressed in gastrula and 243 other tissues.
DR ExpressionAtlas; Q8CJ96; baseline and differential.
DR Genevisible; Q8CJ96; MM.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR033593; N-RASSF.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15286; PTHR15286; 1.
DR Pfam; PF00788; RA; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50200; RA; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..419
FT /note="Ras association domain-containing protein 8"
FT /id="PRO_0000089841"
FT DOMAIN 1..82
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT REGION 372..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 105
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHQ8"
FT MOD_RES 129
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHQ8"
FT MOD_RES 131
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHQ8"
FT MOD_RES 387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NHQ8"
FT CONFLICT 173
FT /note="Q -> E (in Ref. 3; BAB30637)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 419 AA; 48103 MW; A809CFFE0AE62597 CRC64;
MELKVWVDGV QRIVCGVTEV TTCQEVVIAL AQAIGRTGRY TLIEKWRDTE RHLAPHENPI
VSLNKWGQYA SDVQLILRRT GPSLSERPTS DSVARIPERT LYRQSLPPLA KLRPQADKSI
RRREPKRKSL TFTGGAKGLT DIFGKGKETE FRQKVLSNCR ATAEELKRLI RLQTGKLQAI
EKQLESSEAE IRFWEQKYSC SLEEEIVRLE QRIKRNDVEI EEEEFWENEL QIEQENEKQL
QDQLEEIRQK VTDCEGRLKD YLAQIHTMES GLQAEKLHRE VQEAQVNEEE VKGKIEKVKG
EMDLQGQQSL RLENGIRAVE RSLGQATKRL QDKEQELEQL TKELRQVNLQ QFIQQTGTKV
TVLPAEPTEI EASQADIETE APFQSGSLKR PGSSRQLPSN LRILQNPVSS GFNPEGIYV
