ID   RASF9_HUMAN             Reviewed;         435 AA.
AC   O75901; B3KMQ4; Q8N5U8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Ras association domain-containing protein 9;
DE   AltName: Full=PAM COOH-terminal interactor protein 1;
DE            Short=P-CIP1;
DE   AltName: Full=Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor;
GN   Name=RASSF9; Synonyms=PAMCI, PCIP1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9837933; DOI=10.1074/jbc.273.50.33524;
RA   Chen L., Johnson R.C., Milgram S.L.;
RT   "P-CIP1, a novel protein that interacts with the cytosolic domain of
RT   peptidylglycine alpha-amidating monooxygenase, is associated with
RT   endosomes.";
RL   J. Biol. Chem. 273:33524-33532(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=18272789; DOI=10.1091/mbc.e07-07-0652;
RA   Sherwood V., Manbodh R., Sheppard C., Chalmers A.D.;
RT   "RASSF7 is a member of a new family of RAS association domain-containing
RT   proteins and is required for completing mitosis.";
RL   Mol. Biol. Cell 19:1772-1782(2008).
CC   -!- FUNCTION: May play a role in regulating vesicuar trafficking in cells.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PAM. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome. Note=Accumulates on perinuclear
CC       endosomes. {ECO:0000250}.
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DR   EMBL; AF056209; AAD03250.1; -; mRNA.
DR   EMBL; AK022089; BAG51066.1; -; mRNA.
DR   EMBL; CH471054; EAW97399.1; -; Genomic_DNA.
DR   EMBL; BC031589; AAH31589.1; -; mRNA.
DR   CCDS; CCDS44950.1; -.
DR   RefSeq; NP_005438.2; NM_005447.3.
DR   AlphaFoldDB; O75901; -.
DR   SMR; O75901; -.
DR   BioGRID; 114619; 37.
DR   IntAct; O75901; 34.
DR   STRING; 9606.ENSP00000354884; -.
DR   iPTMnet; O75901; -.
DR   PhosphoSitePlus; O75901; -.
DR   BioMuta; RASSF9; -.
DR   EPD; O75901; -.
DR   jPOST; O75901; -.
DR   MassIVE; O75901; -.
DR   MaxQB; O75901; -.
DR   PaxDb; O75901; -.
DR   PeptideAtlas; O75901; -.
DR   PRIDE; O75901; -.
DR   ProteomicsDB; 50256; -.
DR   Antibodypedia; 29875; 123 antibodies from 22 providers.
DR   DNASU; 9182; -.
DR   Ensembl; ENST00000361228.5; ENSP00000354884.3; ENSG00000198774.5.
DR   GeneID; 9182; -.
DR   KEGG; hsa:9182; -.
DR   MANE-Select; ENST00000361228.5; ENSP00000354884.3; NM_005447.4; NP_005438.2.
DR   UCSC; uc001taf.2; human.
DR   CTD; 9182; -.
DR   DisGeNET; 9182; -.
DR   GeneCards; RASSF9; -.
DR   HGNC; HGNC:15739; RASSF9.
DR   HPA; ENSG00000198774; Tissue enhanced (brain).
DR   MIM; 610383; gene.
DR   neXtProt; NX_O75901; -.
DR   OpenTargets; ENSG00000198774; -.
DR   PharmGKB; PA162400725; -.
DR   VEuPathDB; HostDB:ENSG00000198774; -.
DR   eggNOG; KOG1574; Eukaryota.
DR   GeneTree; ENSGT00950000182839; -.
DR   HOGENOM; CLU_036954_0_0_1; -.
DR   InParanoid; O75901; -.
DR   OMA; PANYMKM; -.
DR   OrthoDB; 592471at2759; -.
DR   PhylomeDB; O75901; -.
DR   TreeFam; TF326923; -.
DR   PathwayCommons; O75901; -.
DR   SignaLink; O75901; -.
DR   BioGRID-ORCS; 9182; 12 hits in 1069 CRISPR screens.
DR   GeneWiki; RASSF9; -.
DR   GenomeRNAi; 9182; -.
DR   Pharos; O75901; Tbio.
DR   PRO; PR:O75901; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; O75901; protein.
DR   Bgee; ENSG00000198774; Expressed in mucosa of paranasal sinus and 107 other tissues.
DR   Genevisible; O75901; HS.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0055037; C:recycling endosome; IBA:GO_Central.
DR   GO; GO:0012510; C:trans-Golgi network transport vesicle membrane; IDA:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; NAS:UniProtKB.
DR   GO; GO:0046907; P:intracellular transport; IBA:GO_Central.
DR   GO; GO:0006605; P:protein targeting; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR033593; N-RASSF.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033633; RASSF9.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR15286; PTHR15286; 1.
DR   PANTHER; PTHR15286:SF10; PTHR15286:SF10; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..435
FT                   /note="Ras association domain-containing protein 9"
FT                   /id="PRO_0000299452"
FT   DOMAIN          25..119
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          380..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          195..290
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        391..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         285
FT                   /note="A -> T (in dbSNP:rs7397266)"
FT                   /id="VAR_034820"
FT   CONFLICT        39
FT                   /note="L -> F (in Ref. 1; AAD03250)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   435 AA;  50021 MW;  C9CF3E1C482AAA18 CRC64;
     MAPFGRNLLK TRHKNRSPTK DMDSEEKEIV VWVCQEEKLV CGLTKRTTSA DVIQALLEEH
     EATFGEKRFL LGKPSDYCII EKWRGSERVL PPLTRILKLW KAWGDEQPNM QFVLVKADAF
     LPVPLWRTAE AKLVQNTEKL WELSPANYMK TLPPDKQKRI VRKTFRKLAK IKQDTVSHDR
     DNMETLVHLI ISQDHTIHQQ VKRMKELDLE IEKCEAKFHL DRVENDGENY VQDAYLMPSF
     SEVEQNLDLQ YEENQTLEDL SESDGIEQLE ERLKYYRILI DKLSAEIEKE VKSVCIDINE
     DAEGEAASEL ESSNLESVKC DLEKSMKAGL KIHSHLSGIQ KEIKYSDSLL QMKAKEYELL
     AKEFNSLHIS NKDGCQLKEN RAKESEVPSS NGEIPPFTQR VFSNYTNDTD SDTGISSNHS
     QDSETTVGDV VLLST