RASF9_MOUSE
ID RASF9_MOUSE Reviewed; 435 AA.
AC Q8K342; Q8BZV4;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Ras association domain-containing protein 9;
DE AltName: Full=PAM COOH-terminal interactor protein 1;
DE Short=P-CIP1;
DE AltName: Full=Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor;
GN Name=Rassf9; Synonyms=Pamci, Pcip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in regulating vesicuar trafficking in cells.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PAM. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome. Note=Accumulates on perinuclear
CC endosomes. {ECO:0000250}.
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DR EMBL; AK033464; BAC28302.1; -; mRNA.
DR EMBL; AK041688; BAC31033.1; -; mRNA.
DR EMBL; BC028805; AAH28805.1; -; mRNA.
DR CCDS; CCDS36048.1; -.
DR RefSeq; NP_666352.1; NM_146240.4.
DR AlphaFoldDB; Q8K342; -.
DR SMR; Q8K342; -.
DR STRING; 10090.ENSMUSP00000054767; -.
DR iPTMnet; Q8K342; -.
DR PhosphoSitePlus; Q8K342; -.
DR MaxQB; Q8K342; -.
DR PaxDb; Q8K342; -.
DR PRIDE; Q8K342; -.
DR ProteomicsDB; 254987; -.
DR Antibodypedia; 29875; 123 antibodies from 22 providers.
DR DNASU; 237504; -.
DR Ensembl; ENSMUST00000219445; ENSMUSP00000151843; ENSMUSG00000044921.
DR GeneID; 237504; -.
DR KEGG; mmu:237504; -.
DR UCSC; uc007gyf.1; mouse.
DR CTD; 9182; -.
DR MGI; MGI:2384307; Rassf9.
DR VEuPathDB; HostDB:ENSMUSG00000044921; -.
DR eggNOG; KOG1574; Eukaryota.
DR GeneTree; ENSGT00950000182839; -.
DR HOGENOM; CLU_036954_0_0_1; -.
DR InParanoid; Q8K342; -.
DR OMA; PANYMKM; -.
DR OrthoDB; 592471at2759; -.
DR PhylomeDB; Q8K342; -.
DR TreeFam; TF326923; -.
DR BioGRID-ORCS; 237504; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8K342; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8K342; protein.
DR Bgee; ENSMUSG00000044921; Expressed in lumbar dorsal root ganglion and 154 other tissues.
DR ExpressionAtlas; Q8K342; baseline and differential.
DR Genevisible; Q8K342; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR GO; GO:0055037; C:recycling endosome; ISO:MGI.
DR GO; GO:0012510; C:trans-Golgi network transport vesicle membrane; ISS:UniProtKB.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0019904; F:protein domain specific binding; ISO:MGI.
DR GO; GO:0016197; P:endosomal transport; IEA:InterPro.
DR GO; GO:0046907; P:intracellular transport; ISO:MGI.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR033593; N-RASSF.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033633; RASSF9.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15286; PTHR15286; 1.
DR PANTHER; PTHR15286:SF10; PTHR15286:SF10; 1.
DR SMART; SM00314; RA; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50200; RA; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endosome; Reference proteome.
FT CHAIN 1..435
FT /note="Ras association domain-containing protein 9"
FT /id="PRO_0000299453"
FT DOMAIN 25..119
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 195..291
FT /evidence="ECO:0000255"
FT CONFLICT 370
FT /note="S -> N (in Ref. 1; BAC28302)"
FT /evidence="ECO:0000305"
FT CONFLICT 409
FT /note="T -> A (in Ref. 1; BAC28302)"
FT /evidence="ECO:0000305"
FT CONFLICT 429
FT /note="D -> N (in Ref. 1; BAC28302)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 435 AA; 49582 MW; 4F36702F273DEE49 CRC64;
MAPFGRNLLK TRHKNRSPTK DMDPEEKEIV VWVCQDEKIV CGLTKRTTSI DVIQALLEEH
EATFGEKRFL LGKASDYCIV EKWRGSERAL PPLTRILKLW KAWGDEQPNM QFVLVKTDAF
LPVPLWRTAE TKLVQNNEKP WELSPANYMK TLPPDKQKRI VRKTFRKLAK IRQDTSSHDR
DNMECLVHLI ISQDHTIHQQ VQRMKELDME IEKCEAKIHL DRVGNDGANY VHEAYLMPRL
SDEEQKLDIQ AEINQTLEDL NDSEGMAQLE EQLQYYRALI DKLSAEIERE VKGAGIDGIE
DMEGAAACEL ENSDLESVKC DLETSMKAGL TIHSHLSGIQ REIKYSDSLL QMKAREYELL
AKEFSSLHIS NKDGCQGKEN RGKEAEAPSS NGETPPLTQR VFNIYTNDTD SDTGISSNHS
QDSETTLGDV LLLAT
