ID   RASF9_RAT               Reviewed;         435 AA.
AC   O88869;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Ras association domain-containing protein 9;
DE   AltName: Full=PAM COOH-terminal interactor protein 1;
DE            Short=P-CIP1;
DE   AltName: Full=Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor;
GN   Name=Rassf9; Synonyms=Pamci, Pcip1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH PAM, SUBCELLULAR
RP   LOCATION, AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=9837933; DOI=10.1074/jbc.273.50.33524;
RA   Chen L., Johnson R.C., Milgram S.L.;
RT   "P-CIP1, a novel protein that interacts with the cytosolic domain of
RT   peptidylglycine alpha-amidating monooxygenase, is associated with
RT   endosomes.";
RL   J. Biol. Chem. 273:33524-33532(1998).
CC   -!- FUNCTION: May play a role in regulating vesicuar trafficking in cells.
CC       {ECO:0000269|PubMed:9837933}.
CC   -!- SUBUNIT: Interacts with PAM. {ECO:0000269|PubMed:9837933}.
CC   -!- INTERACTION:
CC       O88869; P14925: Pam; NbExp=3; IntAct=EBI-1395057, EBI-1395008;
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:9837933}.
CC       Note=Accumulates on perinuclear endosomes.
CC   -!- TISSUE SPECIFICITY: Testis, kidney, skeletal muscle, liver, lung,
CC       brain, heart, pituitary gland, adrenal gland and ovary.
CC       {ECO:0000269|PubMed:9837933}.
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DR   EMBL; AF056208; AAD03249.1; -; mRNA.
DR   RefSeq; NP_075248.1; NM_022959.2.
DR   AlphaFoldDB; O88869; -.
DR   SMR; O88869; -.
DR   IntAct; O88869; 1.
DR   STRING; 10116.ENSRNOP00000055632; -.
DR   iPTMnet; O88869; -.
DR   PhosphoSitePlus; O88869; -.
DR   PaxDb; O88869; -.
DR   GeneID; 65053; -.
DR   KEGG; rno:65053; -.
DR   UCSC; RGD:621329; rat.
DR   CTD; 9182; -.
DR   RGD; 621329; Rassf9.
DR   eggNOG; KOG1574; Eukaryota.
DR   InParanoid; O88869; -.
DR   OrthoDB; 592471at2759; -.
DR   PhylomeDB; O88869; -.
DR   PRO; PR:O88869; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR   GO; GO:0005768; C:endosome; IDA:UniProtKB.
DR   GO; GO:0055037; C:recycling endosome; IDA:RGD.
DR   GO; GO:0012510; C:trans-Golgi network transport vesicle membrane; IDA:UniProtKB.
DR   GO; GO:0019899; F:enzyme binding; IPI:RGD.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
DR   GO; GO:0016197; P:endosomal transport; NAS:UniProtKB.
DR   GO; GO:0046907; P:intracellular transport; IDA:RGD.
DR   GO; GO:0006605; P:protein targeting; NAS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR033593; N-RASSF.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033633; RASSF9.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR15286; PTHR15286; 1.
DR   PANTHER; PTHR15286:SF10; PTHR15286:SF10; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Endosome; Reference proteome.
FT   CHAIN           1..435
FT                   /note="Ras association domain-containing protein 9"
FT                   /id="PRO_0000299454"
FT   DOMAIN          25..119
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          371..423
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          195..291
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        391..423
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  49545 MW;  582AF0C52176E9B1 CRC64;
     MAPFGRNLLK TRHKNRSPTK DMDPEEKEIV VWVCQEEKIV CGLTKRTTSI DVIQALLEEH
     EATFGEKRFL LGKASDYCIV EKWRGSERAL PPLTRILKLW KAWGDEQPNM QFVLVKTDAF
     LPVPLWRTAE TKLVQNNEKP WELSPANYMK TLPPDKQKRI VRKTFRKLAK IRQDTGSHDR
     DNMECLVHLI ISQDHTIHQQ VQRMKELDME IEKCEAKIHL DRIGNDGADY VQEAYLMPRS
     SEEEQKLDFQ SEDNQTLEDL NDGEGVSQLE EQLQYYRALI DKLSAEIERE VKGAGTDGSE
     DMEGAAACEL ENSDLESVKC DLEKSMKAGL KIHSHLSGIQ REIKYSDSLL QMKAREYELL
     AKEFSSLHIS SKDGCQGKEN RGKEAEASSS NGEIPPLTQR VFNTYTNDTD SDTGISSNHS
     QDSETTLGDV LLLAT