RASFA_MOUSE
ID RASFA_MOUSE Reviewed; 508 AA.
AC Q8BL43; Q05AF4; Q8C0D3; Q8K340;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Ras association domain-containing protein 10;
GN Name=Rassf10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=29490266; DOI=10.1016/j.celrep.2018.02.019;
RA Qiao H., Li Y., Feng C., Duo S., Ji F., Jiao J.;
RT "Nap1l1 controls embryonic neural progenitor cell proliferation and
RT differentiation in the developing brain.";
RL Cell Rep. 22:2279-2293(2018).
CC -!- FUNCTION: Plays an important role in regulating embryonic neurogenesis.
CC {ECO:0000269|PubMed:29490266}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in neural progenitor cells (at protein
CC level). {ECO:0000269|PubMed:29490266}.
CC -!- DEVELOPMENTAL STAGE: Expression increases from 10 dpc to 12 dpc and
CC gradually decreases after 15 dpc (at protein level).
CC {ECO:0000269|PubMed:29490266}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28854.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};
CC Sequence=BAC27498.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAC32726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK031660; BAC27498.1; ALT_FRAME; mRNA.
DR EMBL; AK046433; BAC32726.1; ALT_INIT; mRNA.
DR EMBL; BC028854; AAH28854.1; ALT_SEQ; mRNA.
DR EMBL; BC125291; AAI25292.1; -; mRNA.
DR EMBL; BC125293; AAI25294.1; -; mRNA.
DR CCDS; CCDS59737.1; -.
DR RefSeq; NP_780488.2; NM_175279.3.
DR AlphaFoldDB; Q8BL43; -.
DR SMR; Q8BL43; -.
DR STRING; 10090.ENSMUSP00000138103; -.
DR iPTMnet; Q8BL43; -.
DR PhosphoSitePlus; Q8BL43; -.
DR PRIDE; Q8BL43; -.
DR ProteomicsDB; 300239; -.
DR Antibodypedia; 74573; 83 antibodies from 20 providers.
DR DNASU; 78748; -.
DR Ensembl; ENSMUST00000182858; ENSMUSP00000138103; ENSMUSG00000098132.
DR GeneID; 78748; -.
DR KEGG; mmu:78748; -.
DR UCSC; uc009jhb.1; mouse.
DR CTD; 644943; -.
DR MGI; MGI:1925998; Rassf10.
DR VEuPathDB; HostDB:ENSMUSG00000098132; -.
DR eggNOG; KOG1574; Eukaryota.
DR GeneTree; ENSGT00950000182839; -.
DR HOGENOM; CLU_036954_0_0_1; -.
DR InParanoid; Q8BL43; -.
DR OMA; KADLDYS; -.
DR OrthoDB; 592471at2759; -.
DR PhylomeDB; Q8BL43; -.
DR BioGRID-ORCS; 78748; 2 hits in 68 CRISPR screens.
DR PRO; PR:Q8BL43; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BL43; protein.
DR Bgee; ENSMUSG00000098132; Expressed in indifferent gonad and 126 other tissues.
DR Genevisible; Q8BL43; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:UniProtKB.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR InterPro; IPR033593; N-RASSF.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR033634; RASSF10.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR15286; PTHR15286; 1.
DR PANTHER; PTHR15286:SF13; PTHR15286:SF13; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS50200; RA; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Cytoskeleton; Neurogenesis; Reference proteome.
FT CHAIN 1..508
FT /note="Ras association domain-containing protein 10"
FT /id="PRO_0000332285"
FT DOMAIN 1..133
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT REGION 51..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 235..266
FT /evidence="ECO:0000255"
FT COILED 319..358
FT /evidence="ECO:0000255"
FT COMPBIAS 190..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 487
FT /note="Missing (in Ref. 1; BAC27498)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 508 AA; 57333 MW; 0EA2744EA7C4B002 CRC64;
MDPSEKKISV WICQEEKLVS GLSRRTTCSD VVRVLLEDGC RRRCRQRRGQ RRGLTEDPSG
QLELPEPPDE NDEDDDDAMP PGMLCGPPQC YCIVEKWRGF ERILPNKTRI LRLWTAWGDE
QENVRFVLVR SEASLPNAGP RSAEARVVLS RERPCLARGA PARPSLALTQ EKQRRVVRKA
FRKLAKLNRR RQQQPSSPCS STSSSTASSC SSSARTHESA SVERMETLVH LVLSQDHTIR
QQVQRLRELD REIDRYEAKV HLDRMRRHGV NYVQDTYLVG AGIDLDGQTP EGEPEDATLE
EKGTEPAAPL DSEAQAAALE ELARRCDDLV RLQEERAQQE ELLERLSAEI QEELNQRWMQ
RRNEELAARE ESLEPDGGPD GELLLEQERV RTQLSTSLYI GLRLSTDLEA VKADLDYSQQ
QRDIKERELQ GLLQSLHTFE QTVVHDGALG SSGPSREPQP QTCAEMWVDQ ARGLAKSCPG
NDEDSDTGLS SMHSQDSDSV PPVCESLV
