ID   RASFA_XENLA             Reviewed;         453 AA.
AC   B1A193; E7DDA4; E7DDA5; E7DDA7;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Ras association domain-containing protein 10;
GN   Name=rassf10;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=18272789; DOI=10.1091/mbc.e07-07-0652;
RA   Sherwood V., Manbodh R., Sheppard C., Chalmers A.D.;
RT   "RASSF7 is a member of a new family of RAS association domain-containing
RT   proteins and is required for completing mitosis.";
RL   Mol. Biol. Cell 19:1772-1782(2008).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 181-342.
RX   PubMed=21044062; DOI=10.1111/j.1558-5646.2010.01163.x;
RA   Bewick A.J., Anderson D.W., Evans B.J.;
RT   "Evolution of the closely related, sex-related genes DM-W and DMRT1 in
RT   African clawed frogs (Xenopus).";
RL   Evolution 65:698-712(2011).
RN   [3]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=20956940; DOI=10.1038/onc.2010.471;
RA   Hill V.K., Underhill-Day N., Krex D., Robel K., Sangan C.B.,
RA   Summersgill H.R., Morris M., Gentle D., Chalmers A.D., Maher E.R.,
RA   Latif F.;
RT   "Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is
RT   a frequent and an early event in gliomagenesis.";
RL   Oncogene 30:978-989(2011).
CC   -!- FUNCTION: May play role in regulating embryonic neurogenesis.
CC       {ECO:0000250|UniProtKB:Q8BL43}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm,
CC       cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: In stage 30 tadpoles, expressed in the dorsal and
CC       ventral forebrain and, at lower levels, the dorsal midbrain and
CC       hindbrain. At this stage, expression is not detected in the spinal
CC       cord, but is present in the overlying dorsal fin. Also expressed in the
CC       eye, trigeminal ganglion, branchial arches and cement gland.
CC       {ECO:0000269|PubMed:20956940}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; EU414773; ABZ80616.1; -; mRNA.
DR   EMBL; HQ221332; ADT90827.1; -; Genomic_DNA.
DR   EMBL; HQ221333; ADT90828.1; -; Genomic_DNA.
DR   EMBL; HQ221334; ADT90829.1; -; Genomic_DNA.
DR   EMBL; HQ221335; ADT90830.1; -; Genomic_DNA.
DR   EMBL; HQ221336; ADT90831.1; -; Genomic_DNA.
DR   EMBL; HQ221337; ADT90832.1; -; Genomic_DNA.
DR   EMBL; HQ221338; ADT90833.1; -; Genomic_DNA.
DR   EMBL; HQ221339; ADT90834.1; -; Genomic_DNA.
DR   EMBL; HQ221340; ADT90835.1; -; Genomic_DNA.
DR   EMBL; HQ221341; ADT90836.1; -; Genomic_DNA.
DR   EMBL; HQ221342; ADT90837.1; -; Genomic_DNA.
DR   EMBL; HQ221343; ADT90838.1; -; Genomic_DNA.
DR   RefSeq; NP_001108492.1; NM_001115020.1.
DR   AlphaFoldDB; B1A193; -.
DR   SMR; B1A193; -.
DR   GeneID; 100141316; -.
DR   KEGG; xla:100141316; -.
DR   CTD; 100141316; -.
DR   Xenbase; XB-GENE-5915054; rassf10.L.
DR   OMA; NTPFCES; -.
DR   OrthoDB; 592471at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 100141316; Expressed in internal ear and 18 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; ISS:UniProtKB.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   InterPro; IPR033593; N-RASSF.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR033634; RASSF10.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR15286; PTHR15286; 2.
DR   PANTHER; PTHR15286:SF13; PTHR15286:SF13; 2.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50200; RA; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Neurogenesis; Reference proteome.
FT   CHAIN           1..453
FT                   /note="Ras association domain-containing protein 10"
FT                   /id="PRO_0000419604"
FT   DOMAIN          1..107
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT   REGION          299..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..453
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          262..295
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        428..453
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  51493 MW;  299740DA789AE2A7 CRC64;
     MENEEWKVSV WICQEEKLVS GLTRRTTCAD VVRVLLADHN EKQAEEGSML MGEEGSMLLG
     PPQCYCIVEK WRGFERILPN KTKILRLWTA WGEEQDNVKF VLVRSEASLP NIGPRSAEAK
     VVLSKESPCH QRTLSKTSTG PTQDKQRRVV RKAFRKLAKI NRKRHETLPK ESSSVEKMET
     LVHLVLSQDH TIRQQVQRIM ELDREIERFE ARTHFDRMKM HGVNYVQETY LVGTVSEKGS
     ASDSNPPSDQ SSQEELFADY AQKCDEVLLL QEQISRQEEA MEQMTVQIQE ELNKRWMERR
     QEELSSKEQE SSLSDSGADQ GGDESQLLLE QEQVKTELSA SLYIGLRLNT DLEAIKADLD
     YTQKMWDDKE QELQSLLHSL NDLETSGCQD LAEISCEDTS LGVTTTGSPT DSWVEKDLGR
     PTNCEANDED SDTGLSSMHS QDSDSGPVCE SLV