RASL3_BOVIN
ID RASL3_BOVIN Reviewed; 1012 AA.
AC A6QQ91;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=RAS protein activator like-3;
GN Name=RASAL3;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thymus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a Ras GTPase-activating protein. Plays an
CC important role in the expansion and functions of natural killer T (NKT)
CC cells in the liver by negatively regulating RAS activity and the down-
CC stream ERK signaling pathway. {ECO:0000250|UniProtKB:Q8C2K5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86YV0}.
CC Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q86YV0}.
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DR EMBL; BC149708; AAI49709.1; -; mRNA.
DR RefSeq; NP_001095706.1; NM_001102236.2.
DR AlphaFoldDB; A6QQ91; -.
DR SMR; A6QQ91; -.
DR STRING; 9913.ENSBTAP00000015416; -.
DR PaxDb; A6QQ91; -.
DR PRIDE; A6QQ91; -.
DR Ensembl; ENSBTAT00000015416; ENSBTAP00000015416; ENSBTAG00000011602.
DR GeneID; 540027; -.
DR KEGG; bta:540027; -.
DR CTD; 64926; -.
DR VEuPathDB; HostDB:ENSBTAG00000011602; -.
DR VGNC; VGNC:33739; RASAL3.
DR eggNOG; KOG3508; Eukaryota.
DR GeneTree; ENSGT00940000161423; -.
DR HOGENOM; CLU_009167_0_0_1; -.
DR InParanoid; A6QQ91; -.
DR OMA; WGRHKSP; -.
DR OrthoDB; 69536at2759; -.
DR TreeFam; TF105303; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000011602; Expressed in mesenteric lymph node and 95 other tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0098562; C:cytoplasmic side of membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.
DR GO; GO:0051142; P:positive regulation of NK T cell proliferation; ISS:UniProtKB.
DR GO; GO:0043087; P:regulation of GTPase activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.506.10; -; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194; PTHR10194; 1.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; SSF48350; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; GTPase activation; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1012
FT /note="RAS protein activator like-3"
FT /id="PRO_0000322565"
FT DOMAIN 193..294
FT /note="PH"
FT DOMAIN 285..405
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 459..651
FT /note="Ras-GAP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00167"
FT REGION 1..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 208..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 990..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 889..989
FT /evidence="ECO:0000255"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 18
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86YV0"
FT MOD_RES 51
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86YV0"
FT MOD_RES 160
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86YV0"
FT MOD_RES 162
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86YV0"
FT MOD_RES 166
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 225
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 229
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 232
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86YV0"
FT MOD_RES 235
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 788
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
FT MOD_RES 791
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C2K5"
SQ SEQUENCE 1012 AA; 110755 MW; D9D0A8F97EBCF271 CRC64;
MDPPSPSRAS QTQPVAPSPL TSYRWHSGGG AEKGAGGFRW GRLAGWGRAQ SHQETTASSQ
PAPRSLFRRV LSAPPKESRT SRLKISKSLW GKNKSPPLDS EPEPENPEPE PELEPLATQI
PEAPTPDVPV WNIEAFTLLD GKLVLLGNED EGPRQPRMGS ASSESSIHVA SGNLKDPDRT
PGKTDPEAAG PHQIHNVRGL LKRLKEKKKA KSELGASASR DGPPSALGSR ESLATISELD
LGAERDVRVW PLHPSLLEEP HCFQVTWAGG SRCFSCRSAA ERDRWIEDLR RHFQPSQDNV
EREETWLSVW VHEVKGLPRA AAAAPGVRTE LWLDGALLAR TTPRAGPGQL FWAERFHFEA
LPPARRLSLR LRGAGPGDAV LGRVALALEE LGIPRAPAAG LERWFPLLGA PAGAALRARI
RARRLRVLPS ERYKELAEFL TFHYARLCGA LELALSAQAK EELAAAMVRV LRATGRAQAL
VTDLGTAELA RSGGREALLF RENTLATKAI DEYMKLVAQD YLQETLGQVV RRLCASTEDC
EVDPSKCPAS DLPQHQSRLR NSCKEVFENI IHSYNWFPAE LGTVFSGWRE ACKARGSEAL
GPRLVCASLF LRLLCPAILS PSLFGLALEH PAPGPARTLT LIAKVIQNLA NRAPFGEKEA
YMSFMNTFLE DHGPAMQHFL DQVATVDADT APSGYQGSSD LALQLAVLHA QLCTIFAELD
QATRDNLEPL PTILHAIEEG RPVPVTVPMC LPAPRTQGHS SISAGEKPGF LAPRDLPKHT
PLISKSQSLR SVHGAGSWAR PRLEEEQPPR LPRPVKRTQS VPAGRPARRR PSAGPRPRPK
GSLHAGPAPR GRPWTGASAS LPRKPSVPWQ RQMDQPRDKD QALGTHRPVG KLAELQCEVA
ALRQDLKMLS GLVESLSTHI RSLSEQQEQL RTQLQLLDSR LREGTAKLDP GRDRSTNEGH
RLKSLECRLA EIESTQAQLK DTIQNLQLLP RTSESQSQPV PLKAPCINGD TT
