ID   RASLC_BOVIN             Reviewed;         266 AA.
AC   Q08E00;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Ras-like protein family member 12;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN   Name=RASL12;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Basal ganglia;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000305}.
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DR   EMBL; BC123490; AAI23491.1; -; mRNA.
DR   RefSeq; NP_001070401.1; NM_001076933.1.
DR   AlphaFoldDB; Q08E00; -.
DR   SMR; Q08E00; -.
DR   STRING; 9913.ENSBTAP00000021899; -.
DR   PaxDb; Q08E00; -.
DR   PRIDE; Q08E00; -.
DR   Ensembl; ENSBTAT00000021899; ENSBTAP00000021899; ENSBTAG00000000062.
DR   GeneID; 614252; -.
DR   KEGG; bta:614252; -.
DR   CTD; 51285; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000062; -.
DR   VGNC; VGNC:33756; RASL12.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000160167; -.
DR   InParanoid; Q08E00; -.
DR   OMA; QAEWNLP; -.
DR   OrthoDB; 1384728at2759; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000000062; Expressed in trachea and 99 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras-type.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..266
FT                   /note="Ras-like protein family member 12"
FT                   /id="PRO_0000333867"
FT   BINDING         27..34
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         74..78
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         134..137
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   266 AA;  29609 MW;  1FAABFABAAC6EF5B CRC64;
     MASVFGKPRA GGGQQSAPLE VNLAILGRRG AGKSALTVKF LTRRFISEYD PNLEDTYSSE
     ETVDHQPVHL RVMDTADLDT PRNCERYLNW AHAFLVVYSV DSRQSFEGSS SYLELLALHA
     KETQRSFPAL LLGNKLDMAQ YRQVTQAEGA ALAGRFGCLF FEVSACLDFE HVQHVFHEAV
     REARRELEKN SLARPLFISE ERAVHHQAPL TARHGLASCT FNTLSTTSLK EMPAVAQAKL
     VTVKSSRAQS KRKAPTLTLL KGFKIF