ID   RASLC_DANRE             Reviewed;         255 AA.
AC   Q7SZ59;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Ras-like protein family member 12;
DE            EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
DE   AltName: Full=RAS-like protein Ris;
GN   Name=RASL12; ORFNames=zgc:63633;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC         Evidence={ECO:0000250|UniProtKB:P01116};
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC       {ECO:0000305}.
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DR   EMBL; BC054128; AAH54128.1; -; mRNA.
DR   RefSeq; NP_956689.1; NM_200395.1.
DR   RefSeq; XP_017212316.1; XM_017356827.1.
DR   AlphaFoldDB; Q7SZ59; -.
DR   SMR; Q7SZ59; -.
DR   STRING; 7955.ENSDARP00000103153; -.
DR   PaxDb; Q7SZ59; -.
DR   Ensembl; ENSDART00000018801; ENSDARP00000022937; ENSDARG00000002701.
DR   Ensembl; ENSDART00000115054; ENSDARP00000103153; ENSDARG00000002701.
DR   Ensembl; ENSDART00000172804; ENSDARP00000142623; ENSDARG00000002701.
DR   Ensembl; ENSDART00000180808; ENSDARP00000146603; ENSDARG00000002701.
DR   GeneID; 393366; -.
DR   KEGG; dre:393366; -.
DR   CTD; 51285; -.
DR   ZFIN; ZDB-GENE-040426-1201; rasl12.
DR   eggNOG; KOG0395; Eukaryota.
DR   GeneTree; ENSGT00940000160167; -.
DR   HOGENOM; CLU_041217_9_4_1; -.
DR   InParanoid; Q7SZ59; -.
DR   OMA; QAEWNLP; -.
DR   OrthoDB; 1384728at2759; -.
DR   PhylomeDB; Q7SZ59; -.
DR   TreeFam; TF318030; -.
DR   PRO; PR:Q7SZ59; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000002701; Expressed in spleen and 17 other tissues.
DR   ExpressionAtlas; Q7SZ59; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR   GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras-type.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00174; RHO; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   2: Evidence at transcript level;
KW   GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..255
FT                   /note="Ras-like protein family member 12"
FT                   /id="PRO_0000333870"
FT   BINDING         30..37
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         77..81
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         137..140
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   255 AA;  28411 MW;  6830AD70D7FE21D0 CRC64;
     MSLMFGKART CNIVTVPEHE PSEVNIVILG AMGSGKSALT VKFLTKRFIS EYDPNLEDTY
     SSEEVVDQQP VLVKVMDTAD QEGPVNGERY LGWANAFIIV YSIDNRSSFE VCQQYLETVS
     LYSKGLQPEA PVILLGNKVD MERYRQVSKA DGAALALRFG CLFFEVSACL DFLSVQHIFH
     EAVREVRRET ERSIRPLFIS EDKSAISLSS APPLTACYKE LPTPATAKLV TVKSSRAQSK
     RRAPTLTLLK GFKIF