RASLC_MOUSE
ID RASLC_MOUSE Reviewed; 266 AA.
AC Q08AT1; Q3TAU9;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Ras-like protein family member 12;
DE EC=3.6.5.2 {ECO:0000250|UniProtKB:P01116};
GN Name=Rasl12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000250|UniProtKB:P01116};
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000305}.
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DR EMBL; AK171623; BAE42569.1; -; mRNA.
DR EMBL; BC125036; AAI25037.1; -; mRNA.
DR CCDS; CCDS23290.1; -.
DR RefSeq; NP_001028330.2; NM_001033158.2.
DR AlphaFoldDB; Q08AT1; -.
DR SMR; Q08AT1; -.
DR STRING; 10090.ENSMUSP00000082580; -.
DR iPTMnet; Q08AT1; -.
DR PhosphoSitePlus; Q08AT1; -.
DR MaxQB; Q08AT1; -.
DR PaxDb; Q08AT1; -.
DR PRIDE; Q08AT1; -.
DR ProteomicsDB; 300242; -.
DR Antibodypedia; 25905; 140 antibodies from 20 providers.
DR DNASU; 70784; -.
DR Ensembl; ENSMUST00000085453; ENSMUSP00000082580; ENSMUSG00000041696.
DR GeneID; 70784; -.
DR KEGG; mmu:70784; -.
DR UCSC; uc009qdf.2; mouse.
DR CTD; 51285; -.
DR MGI; MGI:1918034; Rasl12.
DR VEuPathDB; HostDB:ENSMUSG00000041696; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000160167; -.
DR HOGENOM; CLU_041217_9_4_1; -.
DR InParanoid; Q08AT1; -.
DR OMA; QAEWNLP; -.
DR OrthoDB; 1384728at2759; -.
DR PhylomeDB; Q08AT1; -.
DR TreeFam; TF318030; -.
DR BioGRID-ORCS; 70784; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Rasl12; mouse.
DR PRO; PR:Q08AT1; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q08AT1; protein.
DR Bgee; ENSMUSG00000041696; Expressed in aorta tunica media and 154 other tissues.
DR ExpressionAtlas; Q08AT1; baseline and differential.
DR Genevisible; Q08AT1; MM.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR020849; Small_GTPase_Ras-type.
DR PANTHER; PTHR24070; PTHR24070; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51421; RAS; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Hydrolase; Nucleotide-binding; Reference proteome.
FT CHAIN 1..266
FT /note="Ras-like protein family member 12"
FT /id="PRO_0000333869"
FT BINDING 27..34
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 74..78
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 134..137
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT CONFLICT 56
FT /note="T -> A (in Ref. 1; BAE42569)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29555 MW; 4760AE395F350106 CRC64;
MSSVFGKPRA GSGPHSVPLE VNLAILGRRG AGKSALTVKF LTKRFISEYD PNLEDTYSSE
ETVDHQPVHL RVMDTADLDT PRNCERYLNW AHAFLVVYSV DSRASFEGSS SYLELLALHA
KETQRGYPAL LLGNKLDMAQ YRQVTKAEGA ALAGRFGCLF FEVSACLDFE HVQHVFHEAV
REVRRELDKS PLARPLFISE EKTLSHQTPL TARHGLASCT FNTLSTASLK EMPTVAQAKL
VTVKSSRAQS KRKAPTLTLL KGFKIF
