ID   RASP1_TOXGG             Reviewed;         487 AA.
AC   A0A125YYR0;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   03-AUG-2022, entry version 15.
DE   RecName: Full=Rhoptry apical surface protein 1 {ECO:0000303|PubMed:31492901};
DE            Short=TgRASP1 {ECO:0000303|PubMed:31492901};
GN   Name=RASP1 {ECO:0000303|PubMed:31492901};
GN   ORFNames=TGGT1_235130 {ECO:0000312|EMBL:EPR61906.1};
OS   Toxoplasma gondii (strain ATCC 50853 / GT1).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=507601 {ECO:0000312|Proteomes:UP000005641};
RN   [1] {ECO:0000312|Proteomes:UP000005641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50853 / GT1 {ECO:0000312|Proteomes:UP000005641};
RA   Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA   Roos D., Caler E., Lorenzi H.;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   INTERACTION WITH RASP2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=31492901; DOI=10.1038/s41467-019-11979-z;
RA   Suarez C., Lentini G., Ramaswamy R., Maynadier M., Aquilini E.,
RA   Berry-Sterkers L., Cipriano M., Chen A.L., Bradley P., Striepen B.,
RA   Boulanger M.J., Lebrun M.;
RT   "A lipid-binding protein mediates rhoptry discharge and invasion in
RT   Plasmodium falciparum and Toxoplasma gondii parasites.";
RL   Nat. Commun. 10:4041-4041(2019).
CC   -!- SUBUNIT: Interacts with RASP2. {ECO:0000269|PubMed:31492901}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, rhoptry
CC       membrane {ECO:0000269|PubMed:31492901}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:31492901}; Cytoplasmic side
CC       {ECO:0000269|PubMed:31492901}. Note=Localizes to the extremity of the
CC       neck of the rhoptry (PubMed:31492901). Localizes to pre-rhoptry
CC       compartments as well as mature rhoptries (PubMed:31492901).
CC       {ECO:0000269|PubMed:31492901}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in tachyzoites (at protein level).
CC       {ECO:0000269|PubMed:31492901}.
CC   -!- DISRUPTION PHENOTYPE: No defect in tachyzoite growth, intracellular
CC       replication and host cell invasion. {ECO:0000269|PubMed:31492901}.
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DR   EMBL; AAQM03000118; EPR61906.1; -; Genomic_DNA.
DR   EnsemblProtists; EPR61906; EPR61906; TGGT1_235130.
DR   VEuPathDB; ToxoDB:TGGT1_235130; -.
DR   Proteomes; UP000005641; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Membrane.
FT   CHAIN           1..487
FT                   /note="Rhoptry apical surface protein 1"
FT                   /id="PRO_5007183844"
SQ   SEQUENCE   487 AA;  55099 MW;  5ECEA72C1BA41CE0 CRC64;
     MFVLDPAAIC CCAVTCCCGV GSVCAYRKRQ SIPHPSECAL IGKMYRLCGC HDHDKFDVLI
     EIHEIHDLTQ SGKFFVEVHA GRSEERTGVC SAKKGRVEIQ ERVNIHVRQA DKTLTVRVKK
     QGLTSTEAIG DAVIGVKSEL IDGAFPKRQS FFCQKDGKTA CKIVLSFHRL DTGNVSLGDF
     QMSPLLHQAL LIAQSEAEAR GETLQVDILN MTEVERLRFL SKVLEGPLKQ MSSIGGAWKN
     LYFRAAERRN GKWEWQYWSS KDDCMSGIKK RGAYSFMAIS LVLPDKHDRH CFYIRYHDTG
     GVHDLFFKRV DRDRNLWSDG LFEFIEKLRE YLEKHPEVAM SGRGGHSSRR EKKKEGDVGG
     SRTPRKRDGK ALTPRTGASD DAGDDGIRGR SPRGSDRRAL SHRSFVDPAE LAEKRRVLSP
     RETAADEMTR PRASVLKGRM IEGLMYDRSL QPGEKNEEAS EADERPRERT EGVEYEREEE
     QPLLFTQ