ID   RASP3_TOXGG             Reviewed;        1117 AA.
AC   S7UIF3;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   03-AUG-2022, entry version 16.
DE   RecName: Full=Rhoptry apical surface protein 3 {ECO:0000303|PubMed:31492901};
DE            Short=TgRASP3 {ECO:0000303|PubMed:31492901};
GN   Name=RASP3 {ECO:0000303|PubMed:31492901};
GN   ORFNames=TGGT1_306490 {ECO:0000312|EMBL:EPR57542.1};
OS   Toxoplasma gondii (strain ATCC 50853 / GT1).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX   NCBI_TaxID=507601 {ECO:0000312|Proteomes:UP000005641};
RN   [1] {ECO:0000312|Proteomes:UP000005641}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 50853 / GT1 {ECO:0000312|Proteomes:UP000005641};
RA   Sibley D., Venepally P., Karamycheva S., Hadjithomas M., Khan A., Brunk B.,
RA   Roos D., Caler E., Lorenzi H.;
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   INTERACTION WITH RASP2, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, AND
RP   DISRUPTION PHENOTYPE.
RX   PubMed=31492901; DOI=10.1038/s41467-019-11979-z;
RA   Suarez C., Lentini G., Ramaswamy R., Maynadier M., Aquilini E.,
RA   Berry-Sterkers L., Cipriano M., Chen A.L., Bradley P., Striepen B.,
RA   Boulanger M.J., Lebrun M.;
RT   "A lipid-binding protein mediates rhoptry discharge and invasion in
RT   Plasmodium falciparum and Toxoplasma gondii parasites.";
RL   Nat. Commun. 10:4041-4041(2019).
CC   -!- SUBUNIT: Interacts with RASP2. {ECO:0000269|PubMed:31492901}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, rhoptry
CC       membrane {ECO:0000269|PubMed:31492901}; Peripheral membrane protein
CC       {ECO:0000269|PubMed:31492901}; Cytoplasmic side
CC       {ECO:0000269|PubMed:31492901}. Note=Localizes to the extremity of the
CC       neck of the rhoptry. {ECO:0000269|PubMed:31492901}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in tachyzoites (at protein level).
CC       {ECO:0000269|PubMed:31492901}.
CC   -!- DISRUPTION PHENOTYPE: No defect in tachyzoite growth, intracellular
CC       replication and host cell invasion. {ECO:0000269|PubMed:31492901}.
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DR   EMBL; AAQM03000319; EPR57542.1; -; Genomic_DNA.
DR   EnsemblProtists; EPR57542; EPR57542; TGGT1_306490.
DR   VEuPathDB; ToxoDB:TGGT1_306490; -.
DR   Proteomes; UP000005641; Unassembled WGS sequence.
DR   Gene3D; 1.10.3970.10; -; 1.
DR   InterPro; IPR005607; BSD_dom.
DR   InterPro; IPR035925; BSD_dom_sf.
DR   PROSITE; PS50858; BSD; 1.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Membrane.
FT   CHAIN           1..1117
FT                   /note="Rhoptry apical surface protein 3"
FT                   /id="PRO_0000456210"
FT   DOMAIN          752..788
FT                   /note="BSD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00036"
SQ   SEQUENCE   1117 AA;  120843 MW;  25A50D191C01E506 CRC64;
     MENRPRQQTS GHDCSLGTGD DLSSRPGRVD LLRAHISPTT VKQVSVNHER KVVGSSSSRS
     AVWGISPDGS NAFESKNFGL EGDSNHTVEH EVIKEEDSQK KSPFSCGSAP RVVDSPGASV
     VSREGRVGPP SDGSAVVSGD DETDANNSED GTEDEIVSEE GRRTEDEGDV TSRSDQVPCT
     PPPMWVPEVL SDESEETPLR RVGEERHVSD SSSGGDGYLR GTRQGRVRPH AVPPLFHTPS
     HFTPVRATSS RLISLSSDSE RMHRMAQKVQ TQPEMKPKEL DKEAERKQEQ LRSSKGDNKG
     IFKGLLRQLT RGYTGVAHLF DGLASDFKPH TENEGSSSND VLTEERTVQP SSAVVSDKRV
     TGNGTGVERF KPRVRHRLSQ ECRPSFPEKP DEETSLSTTL PTKLKSLFSF ASSHWNHASP
     GEGEATEAAG ASVSGSSSFL AANANHSPSM LDAYGRPPQK RTQRRSFFGS VAAAASNAFA
     EAGAVAAAAA EAVAAVGQSS SDSSGDSSSE SDHSGRERSR AFRGKRGGSN EITTMRSQRS
     AGHLSFSREP ERESDQGEMT PTGETSGSES ELDQVILTEH ATPFNFVLWA TREAAASLQR
     PLLSGPPEEE AGNAEELRST ENAIHRRELQ RLGRLRAVAL RLLLLICEDD SWCQDGTTRQ
     SAHKGANDGA RRRFPPIVQG VRGRRRSDRD TESPPTEATQ DSEEVDRLWS QWINGSPETE
     GGEDADRKQE EKRLQGRGVS RSRYMWKAAN RMLSVDRRLR KLHSDTAVRR MGETEFWKLY
     FYQVFLLMNR FDRQAHKVLR SLSCSFTLTT GEGGDENQPQ EVAHDVLSQT SGFTESDTSS
     PSPSYGFASS PCTSARLIIP PTGLPDNTEE GEPLSFGGVS LEPKDEEAPE QVRQDGLGAL
     AYAIFSSSRS PSLSSSSSGT TSVSARGTGS SFSRDVGESP LLVPRDSHRS GVGSETYSAG
     GDSPALREKV ISENAGCLPL GRAPSQPTNT VSSVSSNRAY LEPASRRGSF SVVPVSGRRL
     RDALFAKRVS SSSQVNGRVS TSRGTMGEDR HQDQQGDNRL EGPSHLSAHN SLYQLGSRSG
     NCVQIKVKEL KELDGTCGDT HQPGLACKGK EVQGARA