RATA_PSEAE
ID RATA_PSEAE Reviewed; 144 AA.
AC O68560;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Ribosome association toxin RatA;
GN Name=ratA; OrderedLocusNames=PA4767;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RA Ochsner U.O., Vasil A.I., Johnson Z., Vasil M.L.;
RT "Pseudomonas oprX and fur have overlapping transcripts: oprX encodes an
RT outer membrane lipoprotein essential for cell envelope integrity.";
RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC Binds to 50S ribosomal subunits, preventing them from associating with
CC 30S subunits to form 70S ribosomes. Its antitoxin is unknown (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ribosome association toxin RatA family.
CC {ECO:0000305}.
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DR EMBL; AF050676; AAC05676.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG08153.1; -; Genomic_DNA.
DR PIR; C83050; C83050.
DR RefSeq; NP_253455.1; NC_002516.2.
DR RefSeq; WP_003100497.1; NZ_QZGE01000018.1.
DR AlphaFoldDB; O68560; -.
DR SMR; O68560; -.
DR STRING; 287.DR97_2111; -.
DR PaxDb; O68560; -.
DR PRIDE; O68560; -.
DR EnsemblBacteria; AAG08153; AAG08153; PA4767.
DR GeneID; 881791; -.
DR KEGG; pae:PA4767; -.
DR PATRIC; fig|208964.12.peg.4994; -.
DR PseudoCAP; PA4767; -.
DR HOGENOM; CLU_079653_3_1_6; -.
DR InParanoid; O68560; -.
DR OMA; YIDGPFK; -.
DR PhylomeDB; O68560; -.
DR BioCyc; PAER208964:G1FZ6-4880-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0048039; F:ubiquinone binding; IEA:InterPro.
DR GO; GO:0045333; P:cellular respiration; IEA:InterPro.
DR GO; GO:0045947; P:negative regulation of translational initiation; IBA:GO_Central.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:InterPro.
DR CDD; cd07813; COQ10p_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044996; COQ10-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR12901; PTHR12901; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
PE 3: Inferred from homology;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..144
FT /note="Ribosome association toxin RatA"
FT /id="PRO_0000192476"
SQ SEQUENCE 144 AA; 16000 MW; 307AA8AF149670F2 CRC64;
MSTHIQRSAL LPYPARALFD LVNDVKRYPE FLPWCSASQV LEESESLMRA ELTVAKGSLS
QRFTTRNVLV PGASIEMNLE NGPFTELHGV WQFKALGEKA CKITLDLTFD YAGPLVKATL
GPLFTQAANT MVDAFCQRAK QLYG
