ID   RATA_RICPR              Reviewed;         146 AA.
AC   Q9ZDZ7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Ribosome association toxin RatA;
GN   Name=ratA; OrderedLocusNames=RP166;
OS   Rickettsia prowazekii (strain Madrid E).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX   NCBI_TaxID=272947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Madrid E;
RX   PubMed=9823893; DOI=10.1038/24094;
RA   Andersson S.G.E., Zomorodipour A., Andersson J.O., Sicheritz-Ponten T.,
RA   Alsmark U.C.M., Podowski R.M., Naeslund A.K., Eriksson A.-S., Winkler H.H.,
RA   Kurland C.G.;
RT   "The genome sequence of Rickettsia prowazekii and the origin of
RT   mitochondria.";
RL   Nature 396:133-140(1998).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Binds to 50S ribosomal subunits, preventing them from associating with
CC       30S subunits to form 70S ribosomes. Its antitoxin is unknown (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribosome association toxin RatA family.
CC       {ECO:0000305}.
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DR   EMBL; AJ235270; CAA14633.1; -; Genomic_DNA.
DR   PIR; B71727; B71727.
DR   RefSeq; NP_220556.1; NC_000963.1.
DR   RefSeq; WP_004598627.1; NC_000963.1.
DR   AlphaFoldDB; Q9ZDZ7; -.
DR   SMR; Q9ZDZ7; -.
DR   STRING; 272947.RP166; -.
DR   EnsemblBacteria; CAA14633; CAA14633; CAA14633.
DR   GeneID; 57569295; -.
DR   KEGG; rpr:RP166; -.
DR   PATRIC; fig|272947.5.peg.171; -.
DR   eggNOG; COG2867; Bacteria.
DR   HOGENOM; CLU_079653_3_1_5; -.
DR   OMA; YIDGPFK; -.
DR   Proteomes; UP000002480; Chromosome.
DR   GO; GO:0048039; F:ubiquinone binding; IEA:InterPro.
DR   GO; GO:0045333; P:cellular respiration; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:InterPro.
DR   CDD; cd07813; COQ10p_like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR044996; COQ10-like.
DR   InterPro; IPR005031; COQ10_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR12901; PTHR12901; 1.
DR   Pfam; PF03364; Polyketide_cyc; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..146
FT                   /note="Ribosome association toxin RatA"
FT                   /id="PRO_0000192477"
SQ   SEQUENCE   146 AA;  16902 MW;  5CC52235FA03AA98 CRC64;
     MLSFQHTKIL PYKPKKLFDL VWDIKSYPQF LPWCAAARII SENNQEVISE LVIQLKGLSE
     KYNSRVINTI TDNGIYLIDT VAISGPFEYL KSTWQFIPHS TGTELKFFIN FKMTSVILDK
     LIGSYFTIAT EKMILAFEKR AKEVIK