RATA_SHIFL
ID RATA_SHIFL Reviewed; 158 AA.
AC P0AGL6; P52121;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Ribosome association toxin RatA;
GN Name=ratA; Synonyms=yfjG; OrderedLocusNames=SF2678, S2856;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC Binds to 50S ribosomal subunits, preventing them from associating with
CC 30S subunits to form 70S ribosomes. Its antitoxin is unknown (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ribosome association toxin RatA family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN44173.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP17998.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE005674; AAN44173.2; ALT_INIT; Genomic_DNA.
DR EMBL; AE014073; AAP17998.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_708466.2; NC_004337.2.
DR RefSeq; WP_000600189.1; NZ_WPGW01000074.1.
DR AlphaFoldDB; P0AGL6; -.
DR SMR; P0AGL6; -.
DR STRING; 198214.SF2678; -.
DR EnsemblBacteria; AAN44173; AAN44173; SF2678.
DR EnsemblBacteria; AAP17998; AAP17998; S2856.
DR GeneID; 1025684; -.
DR GeneID; 60903686; -.
DR KEGG; sfl:SF2678; -.
DR KEGG; sfx:S2856; -.
DR PATRIC; fig|198214.7.peg.3188; -.
DR HOGENOM; CLU_079653_3_1_6; -.
DR OrthoDB; 1691158at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0048039; F:ubiquinone binding; IEA:InterPro.
DR GO; GO:0045333; P:cellular respiration; IEA:InterPro.
DR GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:InterPro.
DR CDD; cd07813; COQ10p_like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR044996; COQ10-like.
DR InterPro; IPR005031; COQ10_START.
DR InterPro; IPR023393; START-like_dom_sf.
DR PANTHER; PTHR12901; PTHR12901; 1.
DR Pfam; PF03364; Polyketide_cyc; 1.
PE 3: Inferred from homology;
KW Reference proteome; Toxin-antitoxin system.
FT CHAIN 1..158
FT /note="Ribosome association toxin RatA"
FT /id="PRO_0000192475"
SQ SEQUENCE 158 AA; 17727 MW; 68A3A8FBE6AC83D5 CRC64;
MILFVGFLLM EIVMPQISRT ALVPYSAEQM YQLVNDVQSY PQFLPGCTGS RILESTPGQM
TAAVDVSKAG ISKTFTTRNQ LTSNQSILMN LVDGPFKKLI GGWKFTPLSQ EACRIEFHLD
FEFTNKLIEL AFGRVFKELA ANMVQAFTVR AKEVYSAR
