ID   RATA_VIBC3              Reviewed;         144 AA.
AC   A5F376; C3LYL3; P52122; Q9KTQ2;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Ribosome association toxin RatA;
GN   Name=ratA; OrderedLocusNames=VC0395_A0375, VC395_0865;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kovach M.E., Hughes K.J., Harkey C.W., Everiss K.D., Shaffer M.D.,
RA   Peterson K.M.;
RL   Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Binds to 50S ribosomal subunits, preventing them from associating with
CC       30S subunits to form 70S ribosomes. Its antitoxin is unknown (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ribosome association toxin RatA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABQ21297.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ACP08879.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U39068; AAA82716.1; -; Genomic_DNA.
DR   EMBL; CP000627; ABQ21297.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP001235; ACP08879.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000815876.1; NZ_JAACZH010000023.1.
DR   AlphaFoldDB; A5F376; -.
DR   SMR; A5F376; -.
DR   STRING; 345073.VC395_0865; -.
DR   EnsemblBacteria; ABQ21297; ABQ21297; VC0395_A0375.
DR   GeneID; 57739550; -.
DR   KEGG; vco:VC0395_A0375; -.
DR   KEGG; vcr:VC395_0865; -.
DR   PATRIC; fig|345073.21.peg.837; -.
DR   eggNOG; COG2867; Bacteria.
DR   HOGENOM; CLU_079653_3_1_6; -.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0048039; F:ubiquinone binding; IEA:InterPro.
DR   GO; GO:0045333; P:cellular respiration; IEA:InterPro.
DR   GO; GO:0006744; P:ubiquinone biosynthetic process; IEA:InterPro.
DR   CDD; cd07813; COQ10p_like; 1.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR044996; COQ10-like.
DR   InterPro; IPR005031; COQ10_START.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   PANTHER; PTHR12901; PTHR12901; 1.
DR   Pfam; PF03364; Polyketide_cyc; 1.
PE   3: Inferred from homology;
KW   Toxin-antitoxin system.
FT   CHAIN           1..144
FT                   /note="Ribosome association toxin RatA"
FT                   /id="PRO_0000324780"
SQ   SEQUENCE   144 AA;  15875 MW;  5BE8D3774743A7DA CRC64;
     MKQVSRSALV SFSAEQMFHL VNDVARYPEF LPGCSGSCVL EQSEAHMVAS VDVSKAGISK
     TFTTSNQLTP GVSIAMSLVD GPFKTLRGGW FFTPLDEAAC KVELRLEFEF SSKMIELAFG
     KIFNELTSNM VNAFTRRAKQ VYGE