ID   RAV2_SCHPO              Reviewed;         287 AA.
AC   O74387;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Regulator of V-ATPase in vacuolar membrane protein 2;
DE   AltName: Full=RAVE complex subunit rav2;
GN   Name=rav2; ORFNames=SPBC3H7.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [3]
RP   IDENTIFICATION IN THE RAVE COMPLEX, DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=18441123; DOI=10.1128/ec.00037-08;
RA   Dawson K., Toone W.M., Jones N., Wilkinson C.R.;
RT   "Loss of regulators of vacuolar ATPase function and ceramide synthesis
RT   results in multidrug sensitivity in Schizosaccharomyces pombe.";
RL   Eukaryot. Cell 7:926-937(2008).
CC   -!- FUNCTION: Component of the RAVE complex which is required for stable
CC       assembly of the vacuolar ATPase complex V-ATPase.
CC       {ECO:0000269|PubMed:18441123}.
CC   -!- SUBUNIT: Component of the RAVE complex composed of rav1, rav2 and skp1.
CC       {ECO:0000269|PubMed:18441123}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- DISRUPTION PHENOTYPE: Leads to mild sensitivity to a range of drugs
CC       including doxorubicin, cycloheximide, and bleomycine, as well as to
CC       calcium. {ECO:0000269|PubMed:18441123}.
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DR   EMBL; CU329671; CAA20308.1; -; Genomic_DNA.
DR   PIR; T40403; T40403.
DR   RefSeq; NP_595763.1; NM_001021664.2.
DR   AlphaFoldDB; O74387; -.
DR   SMR; O74387; -.
DR   BioGRID; 277527; 27.
DR   STRING; 4896.SPBC3H7.12.1; -.
DR   iPTMnet; O74387; -.
DR   MaxQB; O74387; -.
DR   PaxDb; O74387; -.
DR   PRIDE; O74387; -.
DR   EnsemblFungi; SPBC3H7.12.1; SPBC3H7.12.1:pep; SPBC3H7.12.
DR   GeneID; 2541012; -.
DR   KEGG; spo:SPBC3H7.12; -.
DR   PomBase; SPBC3H7.12; rav2.
DR   VEuPathDB; FungiDB:SPBC3H7.12; -.
DR   eggNOG; ENOG502RMT5; Eukaryota.
DR   HOGENOM; CLU_1031169_0_0_1; -.
DR   InParanoid; O74387; -.
DR   OMA; RSNIAYE; -.
DR   PRO; PR:O74387; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0043291; C:RAVE complex; IPI:PomBase.
DR   GO; GO:0071277; P:cellular response to calcium ion; IMP:PomBase.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; TAS:PomBase.
DR   InterPro; IPR028241; RAVE2/Rogdi.
DR   PANTHER; PTHR13618; PTHR13618; 1.
DR   Pfam; PF10259; Rogdi_lz; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..287
FT                   /note="Regulator of V-ATPase in vacuolar membrane protein
FT                   2"
FT                   /id="PRO_0000116863"
SQ   SEQUENCE   287 AA;  32069 MW;  8B96826252B78E14 CRC64;
     MQTEIDASVI VKEKEWLETN VLPEFWESMS EGLKEALNLI SSDDPTVLVF TSPKTDAVKG
     IVSRSSSNVV RVNVTAKVGR TTHVLKLKDS AIIHLDQILN LSNYMHYALY CLPRLRHNTE
     RAIKELQEIL HAIVCLLHSI MQEESEKEEI PSNASSISLK SQNSIVSRTS NPFSCLNHSP
     RQIHKTVRNH LFSPPLPSNL ALSFSISNAS VCLHLFRLSG PNEVLESFAK NSVDIEMLKP
     FVSQRIDAFS QDPILLAVTA KLSALQKKVN DVSYRFKTIS SSLYGAK