RAVR2_MOUSE
ID RAVR2_MOUSE Reviewed; 673 AA.
AC Q7TPD6; B1ASP1;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Ribonucleoprotein PTB-binding 2;
DE AltName: Full=Protein raver-2;
GN Name=Raver2; Synonyms=Kiaa1579;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUBCELLULAR LOCATION, INTERACTION WITH RAVER1 AND PTBP1, AND TISSUE
RP SPECIFICITY.
RX PubMed=16051233; DOI=10.1016/j.febslet.2005.07.001;
RA Kleinhenz B., Fabienke M., Swiniarski S., Wittenmayer N., Kirsch J.,
RA Jockusch B.M., Arnold H.H., Illenberger S.;
RT "Raver2, a new member of the hnRNP family.";
RL FEBS Lett. 579:4254-4258(2005).
CC -!- FUNCTION: May bind single-stranded nucleic acids. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with PTBP1 and RAVER1.
CC {ECO:0000269|PubMed:16051233}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16051233}. Cytoplasm
CC {ECO:0000269|PubMed:16051233}. Note=May shuttle between the nucleus and
CC the cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed throughout embryogenesis. Detected at low
CC levels in adult lung, brain and kidney, but not in the other tissues
CC tested. {ECO:0000269|PubMed:16051233}.
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DR EMBL; AL627251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC055329; AAH55329.1; -; mRNA.
DR CCDS; CCDS18392.1; -.
DR RefSeq; NP_898845.1; NM_183024.1.
DR AlphaFoldDB; Q7TPD6; -.
DR SMR; Q7TPD6; -.
DR BioGRID; 232424; 1.
DR IntAct; Q7TPD6; 1.
DR MINT; Q7TPD6; -.
DR STRING; 10090.ENSMUSP00000043142; -.
DR iPTMnet; Q7TPD6; -.
DR PhosphoSitePlus; Q7TPD6; -.
DR MaxQB; Q7TPD6; -.
DR PaxDb; Q7TPD6; -.
DR PRIDE; Q7TPD6; -.
DR ProteomicsDB; 253175; -.
DR Antibodypedia; 51338; 68 antibodies from 14 providers.
DR Ensembl; ENSMUST00000038463; ENSMUSP00000043142; ENSMUSG00000035275.
DR GeneID; 242570; -.
DR KEGG; mmu:242570; -.
DR UCSC; uc008tvj.1; mouse.
DR CTD; 55225; -.
DR MGI; MGI:2443623; Raver2.
DR VEuPathDB; HostDB:ENSMUSG00000035275; -.
DR eggNOG; KOG0145; Eukaryota.
DR GeneTree; ENSGT00940000158648; -.
DR HOGENOM; CLU_016492_2_0_1; -.
DR InParanoid; Q7TPD6; -.
DR OMA; LTGHHKQ; -.
DR OrthoDB; 249777at2759; -.
DR PhylomeDB; Q7TPD6; -.
DR TreeFam; TF331660; -.
DR BioGRID-ORCS; 242570; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Raver2; mouse.
DR PRO; PR:Q7TPD6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q7TPD6; protein.
DR Bgee; ENSMUSG00000035275; Expressed in humerus cartilage element and 69 other tissues.
DR ExpressionAtlas; Q7TPD6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR034636; RAVER2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR23189:SF6; PTHR23189:SF6; 1.
DR Pfam; PF00076; RRM_1; 3.
DR SMART; SM00360; RRM; 3.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 3.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1..673
FT /note="Ribonucleoprotein PTB-binding 2"
FT /id="PRO_0000081491"
FT DOMAIN 58..129
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 131..209
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 220..298
FT /note="RRM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 72031 MW; 6E31A65A272CE243 CRC64;
MAARGGGAGG AGSGSGPSAG TAGEAAEPAL RPGEVAALHP QEVAARLQRM RRELSNRRKI
LVKNLPQDSS SQEVHELLQD YELKYCYVDR NKRTAFVTLL NGEQAQSAIQ RFHQFSFRGR
ELTVQLQPTD ALLCITNLPI SFTLEEFEEL VRAYGNIERC FLVYSEVTGH SKGYGFVEYM
KKDFAAKARL ELLGRQMGAS ALFAQWMDVN LLASELIHSK CLCIDKLPSD YSDSEELLQL
FSGIHKPVFC QLAQDEGSHG GGFAVVEYST AEHAEEVQQV ADGITIKGSQ VQLSFCAPGA
PGRSTLAVLI AAQRAMHSNQ KGLLPEPNPV QIMKSLNNPA MLQVLLQPQL CGRAMKPVLG
VAPSLSHLLS PSLPSAILHF SKAQQSSAVG NTSSLILQNL SPLPLIQQQL MKFDNAHTNN
KPGLLGEPPA MVLQPALAIG PPLPLKTDLG HHGEAHKTSN LIPPQTTLAA GLGMLPFFSN
QLPAGQAGPG RGTTQEKQSA SVSISEASFS GSQHYLQTFP GLPAGGPLTG NQKTPQSQPK
GTEVASKNQT SLLGEPPKEI RLSKNPYLNL ASVLPSVCLS TAGKGMPPKT GIASNILDAI
SQGSESQHAL EKCIAYSPSI EDYAQASSLR NEKRGSSYLI SAPEGGPVEL AGQHPQDTGV
SYTETYLKKK RVY
