RAX1_ARATH
ID RAX1_ARATH Reviewed; 329 AA.
AC Q9FG68; A5YZ30; A5YZ33; A5YZ38; A5YZ50; A5YZ51; Q70YU8; Q70YV2; Q70YV7;
AC Q70YV9; Q70YW0; Q70YW1; Q9ZTE5;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Transcription factor RAX1;
DE AltName: Full=Myb-related protein 37;
DE Short=AtMYB37;
DE AltName: Full=Protein REGULATOR OF AXILLARY MERISTEMS 1;
GN Name=RAX1; Synonyms=MYB37; OrderedLocusNames=At5g23000; ORFNames=T20O7.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kroymann J., Schnabelrauch D., Mitchell-Olds T.;
RT "A MYB transcription factor and a gene similar to MYJ24.1 are encoded in
RT the region between MRN17 and MYJ24.";
RL Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Qu L.-J., Gu H.;
RT "The MYB transcription factor family in Arabidopsis: a genome-wide cloning
RT and expression pattern analysis.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=17147637; DOI=10.1111/j.1467-7652.2006.00183.x;
RA Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.;
RT "Simultaneous high-throughput recombinational cloning of open reading
RT frames in closed and open configurations.";
RL Plant Biotechnol. J. 4:317-324(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 55-329.
RC STRAIN=cv. Columbia;
RX PubMed=9839469; DOI=10.1046/j.1365-313x.1998.00278.x;
RA Kranz H.D., Denekamp M., Greco R., Jin H.-L., Leyva A., Meissner R.C.,
RA Petroni K., Urzainqui A., Bevan M., Martin C., Smeekens S., Tonelli C.,
RA Paz-Ares J., Weisshaar B.;
RT "Towards functional characterisation of the members of the R2R3-MYB gene
RT family from Arabidopsis thaliana.";
RL Plant J. 16:263-276(1998).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 90-329, AND VARIANTS ARG-142; LYS-143;
RP PHE-170; ASN-222 AND VAL-245.
RC STRAIN=cv. Aa-0, cv. Ag-0, cv. Bl-0, cv. Bla-10, cv. Cal-0, cv. Can-0,
RC cv. Cnt-1, cv. Cvi-0, cv. Di-0, cv. Di-1, cv. Di-G, cv. Ema-1, cv. HOG,
RC cv. Ka-0, cv. Kas-1, cv. Kil-1, cv. Kon, cv. Landsberg erecta, cv. Lip-0,
RC cv. Ma-0, cv. Mr-0, cv. Mrk-0, cv. Mt-0, cv. No-0, cv. Oy-0, cv. Pa-1,
RC cv. Per-1, cv. Petergof, cv. Pi-0, cv. Pla-0, cv. Sei-0, cv. Sorbo,
RC cv. Su-0, cv. Tac-0, cv. Tsu-1, cv. Wl-0, and cv. Yo-0;
RX PubMed=14506289; DOI=10.1073/pnas.1734046100;
RA Kroymann J., Donnerhacke S., Schnabelrauch D., Mitchell-Olds T.;
RT "Evolutionary dynamics of an Arabidopsis insect resistance quantitative
RT trait locus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:14587-14592(2003).
RN [9]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 119-307, AND VARIANTS ARG-142;
RP LYS-143; PHE-170; ASN-222 AND VAL-245.
RC STRAIN=cv. Ag-0, cv. An-1, cv. Br-0, cv. C24, cv. Ct-1, cv. Cvi-1,
RC cv. Edi-0, cv. Ga-0, cv. Kas-1, cv. Kin-0, cv. Landsberg erecta, cv. Ll-0,
RC cv. Lz-0, cv. Ms-0, cv. Mt-0, cv. Nd-1, cv. Nok-3, cv. Oy-0, cv. Se-0,
RC cv. Sorbo, cv. Tsu-1, cv. Van-0, cv. Wa-1, and cv. Wassilewskija;
RX PubMed=17435248; DOI=10.1534/genetics.107.071928;
RA Ehrenreich I.M., Stafford P.A., Purugganan M.D.;
RT "The genetic architecture of shoot branching in Arabidopsis thaliana: a
RT comparative assessment of candidate gene associations vs. quantitative
RT trait locus mapping.";
RL Genetics 176:1223-1236(2007).
RN [10]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=11597504; DOI=10.1016/s1369-5266(00)00199-0;
RA Stracke R., Werber M., Weisshaar B.;
RT "The R2R3-MYB gene family in Arabidopsis thaliana.";
RL Curr. Opin. Plant Biol. 4:447-456(2001).
RN [11]
RP FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=16461581; DOI=10.1105/tpc.105.038745;
RA Mueller D., Schmitz G., Theres K.;
RT "Blind homologous R2R3 Myb genes control the pattern of lateral meristem
RT initiation in Arabidopsis.";
RL Plant Cell 18:586-597(2006).
RN [12]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16473968; DOI=10.1105/tpc.105.038588;
RA Keller T., Abbott J., Moritz T., Doerner P.;
RT "Arabidopsis REGULATOR OF AXILLARY MERISTEMS1 controls a leaf axil stem
RT cell niche and modulates vegetative development.";
RL Plant Cell 18:598-611(2006).
RN [13]
RP GENE FAMILY.
RX PubMed=16463103; DOI=10.1007/s11103-005-2910-y;
RA Chen Y., Yang X., He K., Liu M., Li J., Gao Z., Lin Z., Zhang Y., Wang X.,
RA Qiu X., Shen Y., Zhang L., Deng X., Luo J., Deng X.-W., Chen Z., Gu H.,
RA Qu L.-J.;
RT "The MYB transcription factor superfamily of Arabidopsis: expression
RT analysis and phylogenetic comparison with the rice MYB family.";
RL Plant Mol. Biol. 60:107-124(2006).
CC -!- FUNCTION: Transcription activator of genes involved in the regulation
CC of meristematic competence, such as CUC2. Positively regulates axillary
CC meristems (AMs) formation and development, especially at early phases
CC of vegetative growth, probably by specifying a stem cell niche for AM
CC formation. Modulates the negative regulation mediated by gibberellic
CC acid on the timing of developmental phase transitions.
CC {ECO:0000269|PubMed:16461581, ECO:0000269|PubMed:16473968}.
CC -!- INTERACTION:
CC Q9FG68; Q93Z00: TCP14; NbExp=3; IntAct=EBI-15198339, EBI-4424563;
CC Q9FG68; Q9C9L2: TCP15; NbExp=3; IntAct=EBI-15198339, EBI-4426144;
CC Q9FG68; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15198339, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in roots. Also present in shoot
CC tips and flower buds. {ECO:0000269|PubMed:16461581}.
CC -!- DEVELOPMENTAL STAGE: Accumulates in an adaxial ball-shaped set of cells
CC in three to five cell layers around the L3 layer of the shoot apical
CC meristem (SAM) in youg plantlets. Later, expressed transiently at the
CC center of the boundary between the SAM and developing leaf primordia.
CC In the inflorescence meristem, confined to the axils of flower
CC primordia. {ECO:0000269|PubMed:16461581, ECO:0000269|PubMed:16473968}.
CC -!- INDUCTION: By a shift from short days to long days, in the axils of
CC primordia on the elongating stem. {ECO:0000269|PubMed:16461581}.
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DR EMBL; AJ131517; CAC80101.1; -; Genomic_DNA.
DR EMBL; AY519628; AAS10098.1; -; mRNA.
DR EMBL; AB026660; BAB08873.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93106.1; -; Genomic_DNA.
DR EMBL; DQ446976; ABE66175.1; -; mRNA.
DR EMBL; AK175507; BAD43270.1; -; mRNA.
DR EMBL; AF062879; AAC83601.1; -; mRNA.
DR EMBL; AJ486900; CAD31158.1; -; Genomic_DNA.
DR EMBL; AJ486901; CAD31159.1; -; Genomic_DNA.
DR EMBL; AJ486902; CAD31160.1; -; Genomic_DNA.
DR EMBL; AJ486903; CAD31161.1; -; Genomic_DNA.
DR EMBL; AJ486904; CAD31162.1; -; Genomic_DNA.
DR EMBL; AJ486905; CAD31163.1; -; Genomic_DNA.
DR EMBL; AJ486906; CAD31164.1; -; Genomic_DNA.
DR EMBL; AJ486907; CAD31165.1; -; Genomic_DNA.
DR EMBL; AJ486908; CAD31166.1; -; Genomic_DNA.
DR EMBL; AJ486909; CAD31167.1; -; Genomic_DNA.
DR EMBL; AJ486910; CAD31168.1; -; Genomic_DNA.
DR EMBL; AJ486911; CAD31169.1; -; Genomic_DNA.
DR EMBL; AJ486912; CAD31170.1; -; Genomic_DNA.
DR EMBL; AJ486913; CAD31171.1; -; Genomic_DNA.
DR EMBL; AJ486914; CAD31172.1; -; Genomic_DNA.
DR EMBL; AJ486915; CAD31173.1; -; Genomic_DNA.
DR EMBL; AJ486916; CAD31174.1; -; Genomic_DNA.
DR EMBL; AJ486917; CAD31175.1; -; Genomic_DNA.
DR EMBL; AJ486918; CAD31176.1; -; Genomic_DNA.
DR EMBL; AJ486919; CAD31177.1; -; Genomic_DNA.
DR EMBL; AJ486920; CAD31178.1; -; Genomic_DNA.
DR EMBL; AJ486921; CAD31179.1; -; Genomic_DNA.
DR EMBL; AJ486922; CAD31180.1; -; Genomic_DNA.
DR EMBL; AJ486923; CAD31181.1; -; Genomic_DNA.
DR EMBL; AJ486924; CAD31182.1; -; Genomic_DNA.
DR EMBL; AJ486925; CAD31183.1; -; Genomic_DNA.
DR EMBL; AJ486926; CAD31184.1; -; Genomic_DNA.
DR EMBL; AJ486927; CAD31185.1; -; Genomic_DNA.
DR EMBL; AJ486928; CAD31186.1; -; Genomic_DNA.
DR EMBL; AJ486929; CAD31187.1; -; Genomic_DNA.
DR EMBL; AJ486930; CAD31188.1; -; Genomic_DNA.
DR EMBL; AJ486931; CAD31189.1; -; Genomic_DNA.
DR EMBL; AJ486932; CAD31190.1; -; Genomic_DNA.
DR EMBL; AJ486933; CAD31191.1; -; Genomic_DNA.
DR EMBL; AJ486934; CAD31192.1; -; Genomic_DNA.
DR EMBL; AJ486935; CAD31193.1; -; Genomic_DNA.
DR EMBL; AJ486936; CAD31194.1; -; Genomic_DNA.
DR EMBL; EF598612; ABQ85336.1; -; Genomic_DNA.
DR EMBL; EF598613; ABQ85337.1; -; Genomic_DNA.
DR EMBL; EF598614; ABQ85338.1; -; Genomic_DNA.
DR EMBL; EF598615; ABQ85339.1; -; Genomic_DNA.
DR EMBL; EF598616; ABQ85340.1; -; Genomic_DNA.
DR EMBL; EF598617; ABQ85341.1; -; Genomic_DNA.
DR EMBL; EF598618; ABQ85342.1; -; Genomic_DNA.
DR EMBL; EF598619; ABQ85343.1; -; Genomic_DNA.
DR EMBL; EF598620; ABQ85344.1; -; Genomic_DNA.
DR EMBL; EF598621; ABQ85345.1; -; Genomic_DNA.
DR EMBL; EF598622; ABQ85346.1; -; Genomic_DNA.
DR EMBL; EF598623; ABQ85347.1; -; Genomic_DNA.
DR EMBL; EF598624; ABQ85348.1; -; Genomic_DNA.
DR EMBL; EF598625; ABQ85349.1; -; Genomic_DNA.
DR EMBL; EF598626; ABQ85350.1; -; Genomic_DNA.
DR EMBL; EF598627; ABQ85351.1; -; Genomic_DNA.
DR EMBL; EF598628; ABQ85352.1; -; Genomic_DNA.
DR EMBL; EF598629; ABQ85353.1; -; Genomic_DNA.
DR EMBL; EF598630; ABQ85354.1; -; Genomic_DNA.
DR EMBL; EF598631; ABQ85355.1; -; Genomic_DNA.
DR EMBL; EF598632; ABQ85356.1; -; Genomic_DNA.
DR EMBL; EF598633; ABQ85357.1; -; Genomic_DNA.
DR EMBL; EF598634; ABQ85358.1; -; Genomic_DNA.
DR EMBL; EF598635; ABQ85359.1; -; Genomic_DNA.
DR PIR; T51651; T51651.
DR RefSeq; NP_197691.1; NM_122206.4.
DR AlphaFoldDB; Q9FG68; -.
DR SMR; Q9FG68; -.
DR BioGRID; 17639; 10.
DR IntAct; Q9FG68; 10.
DR STRING; 3702.AT5G23000.1; -.
DR PaxDb; Q9FG68; -.
DR PRIDE; Q9FG68; -.
DR EnsemblPlants; AT5G23000.1; AT5G23000.1; AT5G23000.
DR GeneID; 832364; -.
DR Gramene; AT5G23000.1; AT5G23000.1; AT5G23000.
DR KEGG; ath:AT5G23000; -.
DR Araport; AT5G23000; -.
DR TAIR; locus:2181146; AT5G23000.
DR eggNOG; KOG0048; Eukaryota.
DR HOGENOM; CLU_028567_6_2_1; -.
DR InParanoid; Q9FG68; -.
DR OMA; IRSEIMM; -.
DR OrthoDB; 1499244at2759; -.
DR PhylomeDB; Q9FG68; -.
DR PRO; PR:Q9FG68; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FG68; baseline and differential.
DR Genevisible; Q9FG68; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0090506; P:axillary shoot meristem initiation; IGI:TAIR.
DR CDD; cd00167; SANT; 2.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation.
FT CHAIN 1..329
FT /note="Transcription factor RAX1"
FT /id="PRO_0000312431"
FT DOMAIN 9..62
FT /note="HTH myb-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DOMAIN 63..117
FT /note="HTH myb-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 38..62
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT DNA_BIND 90..113
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00625"
FT REGION 122..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 142
FT /note="K -> R (in strain: cv. Ag-0)"
FT /evidence="ECO:0000269|PubMed:14506289,
FT ECO:0000269|PubMed:17435248"
FT VARIANT 143
FT /note="R -> K (in strain: cv. Br-0 and cv. Cal-0)"
FT /evidence="ECO:0000269|PubMed:14506289,
FT ECO:0000269|PubMed:17435248"
FT VARIANT 170
FT /note="L -> F (in strain: cv. Cvi-0 and cv. Cvi-1)"
FT /evidence="ECO:0000269|PubMed:14506289,
FT ECO:0000269|PubMed:17435248"
FT VARIANT 222
FT /note="K -> N (in strain: cv. An-1, cv. Bl-0, cv. Bla-10,
FT cv. C24, cv. Br-0, cv. Cal-0, cv. Can-0, cv. Cnt-1, cv.
FT Kon, cv. Ct-1, cv. Cvi-0, cv. Cvi-1, cv. Di-1, cv. Di-G,
FT cv. Edi-0, cv. Ema-1, cv. Ga-0, cv. Hodja-Obi-Garm, cv. Ka-
FT 0, cv. Kas-1, cv. Kil-1, cv. Landsberg erecta, cv. Lip-0,
FT cv. Ll-0, cv. Lz-0, cv. Mr-0, cv. Mrk-0, cv. Ms-0, cv. Nd-
FT 1, cv. No-0, cv. Nok-3, cv. Oy-0, cv. Pa-1, cv. Per-1, cv.
FT Petergof, cv. Pi-0, cv. Pla-0, cv, cv. Se-0. Sei-0, cv.
FT Sorbo, cv. Su-0, cv. Tac-0, cv. Tsu-1, cv. Van-0, cv. Wa-1,
FT cv. Wl-0, cv. Wassilewskija and cv. Yo-0)"
FT /evidence="ECO:0000269|PubMed:14506289,
FT ECO:0000269|PubMed:17435248"
FT VARIANT 245
FT /note="I -> V (in strain: cv. Cvi-0 and cv. Cvi-1)"
FT /evidence="ECO:0000269|PubMed:14506289,
FT ECO:0000269|PubMed:17435248"
FT CONFLICT 61
FT /note="Y -> F (in Ref. 7; AAC83601)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="V -> A (in Ref. 7; AAC83601)"
FT /evidence="ECO:0000305"
FT CONFLICT 258
FT /note="R -> K (in Ref. 7; AAC83601)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 37045 MW; 4E4E51D4732099B4 CRC64;
MGRAPCCDKT KVKRGPWSPE EDSKLRDYIE KYGNGGNWIS FPLKAGLRRC GKSCRLRWLN
YLRPNIKHGD FSEEEDRIIF SLFAAIGSRW SIIAAHLPGR TDNDIKNYWN TKLRKKLLSS
SSDSSSSAMA SPYLNPISQD VKRPTSPTTI PSSSYNPYAE NPNQYPTKSL ISSINGFEAG
DKQIISYINP NYPQDLYLSD SNNNTSNANG FLLNHNMCDQ YKNHTSFSSD VNGIRSEIMM
KQEEIMMMMM IDHHIDQRTK GYNGEFTQGY YNYYNGHGDL KQMISGTGTN SNINMGGSGS
SSSSISNLAE NKSSGSLLLE YKCLPYFYS
