ID   RAX2_BOVIN              Reviewed;         184 AA.
AC   Q7YRX0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Retina and anterior neural fold homeobox protein 2;
DE   AltName: Full=Q50-type retinal homeobox protein;
DE   AltName: Full=Retina and anterior neural fold homeobox-like protein 1;
GN   Name=RAX2; Synonyms=QRX, RAXL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15028672; DOI=10.1093/hmg/ddh117;
RA   Wang Q.-L., Chen S., Esumi N., Swain P.K., Haines H.S., Peng G.,
RA   Melia B.M., McIntosh I., Heckenlively J.R., Jacobson S.G., Stone E.M.,
RA   Swaroop A., Zack D.J.;
RT   "QRX, a novel homeobox gene, modulates photoreceptor gene expression.";
RL   Hum. Mol. Genet. 13:1025-1040(2004).
CC   -!- FUNCTION: May be involved in modulating the expression of photoreceptor
CC       specific genes. Binds to the Ret-1 and Bat-1 element within the
CC       rhodopsin promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CRX. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in retina. Stronger expression in cells
CC       of the outer nuclear layers than in cells of the inner nuclear layers.
CC       Also weakly detected in brain, testis and spleen.
CC       {ECO:0000269|PubMed:15028672}.
CC   -!- DEVELOPMENTAL STAGE: Detected as early as 4.5 months gestation.
CC       {ECO:0000269|PubMed:15028672}.
CC   -!- DOMAIN: The Homeobox transactivates the Ret-1 element in the presence
CC       of CRX and NRL. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY211276; AAP41546.1; -; mRNA.
DR   RefSeq; NP_872594.1; NM_182653.1.
DR   RefSeq; XP_010805266.1; XM_010806964.2.
DR   AlphaFoldDB; Q7YRX0; -.
DR   SMR; Q7YRX0; -.
DR   IntAct; Q7YRX0; 1.
DR   STRING; 9913.ENSBTAP00000012858; -.
DR   PaxDb; Q7YRX0; -.
DR   Ensembl; ENSBTAT00000012858; ENSBTAP00000012858; ENSBTAG00000009750.
DR   GeneID; 359713; -.
DR   KEGG; bta:359713; -.
DR   CTD; 84839; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009750; -.
DR   VGNC; VGNC:33767; RAX2.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000163572; -.
DR   HOGENOM; CLU_047013_4_0_1; -.
DR   InParanoid; Q7YRX0; -.
DR   OMA; MFLSKCE; -.
DR   OrthoDB; 1085093at2759; -.
DR   TreeFam; TF315976; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000009750; Expressed in retina and 5 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR036934; Homeobox_RAX2.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   PANTHER; PTHR46271:SF2; PTHR46271:SF2; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Sensory transduction;
KW   Transcription; Transcription regulation; Vision.
FT   CHAIN           1..184
FT                   /note="Retina and anterior neural fold homeobox protein 2"
FT                   /id="PRO_0000285046"
FT   DNA_BIND        27..86
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   184 AA;  20168 MW;  F94082F544880A2E CRC64;
     MFLSPGEGPA AEGGGPGPGE EAPKKKHRRN RTTFTTYQLH QLERAFEASH YPDVYSREEL
     AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSGAVAAPRL PEVPALPFAR PPTMPLSLEP
     WLGPGPPAVP ALPRLLGSGP GLQGSFGPHA FSPAFMDGFT LEEGSLRLLA KEHVQALDRA
     WPSA