ID   RAX2_PANPA              Reviewed;         184 AA.
AC   A1YG25;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Retina and anterior neural fold homeobox protein 2;
DE   AltName: Full=Retina and anterior neural fold homeobox-like protein 1;
GN   Name=RAX2; Synonyms=RAXL1;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in modulating the expression of photoreceptor
CC       specific genes. Binds to the Ret-1 and Bat-1 element within the
CC       rhodopsin promoter (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with CRX. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DOMAIN: The Homeobox transactivates the Ret-1 element in the presence
CC       of CRX and NRL. {ECO:0000250}.
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DR   EMBL; DQ977206; ABM54250.1; -; Genomic_DNA.
DR   STRING; 9597.XP_008970948.1; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   Proteomes; UP000240080; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR036934; Homeobox_RAX2.
DR   InterPro; IPR043562; RAX/RAX2.
DR   PANTHER; PTHR46271; PTHR46271; 1.
DR   PANTHER; PTHR46271:SF2; PTHR46271:SF2; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Sensory transduction;
KW   Transcription; Transcription regulation; Vision.
FT   CHAIN           1..184
FT                   /note="Retina and anterior neural fold homeobox protein 2"
FT                   /id="PRO_0000285049"
FT   DNA_BIND        27..86
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   184 AA;  20068 MW;  03264E8EA8BB9947 CRC64;
     MFLSPGXGPA TEGGGLGPGE EAPKKKHRRN RTTFTTYQLH QLERAFEASH YPDVYSREEL
     AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSGAVAAPRL PEAPALPFAR PPAMSLPLEP
     WLGPGPPAVP GLPRLLGPGP GLQASFGPHA FAPTFADGFA LEEASLRLLA KEHAQALDRA
     WPPA