RAX2_PANTR
ID RAX2_PANTR Reviewed; 184 AA.
AC A2T711;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Retina and anterior neural fold homeobox protein 2;
DE AltName: Full=Retina and anterior neural fold homeobox-like protein 1;
GN Name=RAX2; Synonyms=RAXL1;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in modulating the expression of photoreceptor
CC specific genes. Binds to the Ret-1 and Bat-1 element within the
CC rhodopsin promoter (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CRX. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DOMAIN: The Homeobox transactivates the Ret-1 element in the presence
CC of CRX and NRL. {ECO:0000250}.
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DR EMBL; DQ977350; ABM91966.1; -; Genomic_DNA.
DR RefSeq; NP_001074956.1; NM_001081487.1.
DR RefSeq; XP_009432636.1; XM_009434361.2.
DR AlphaFoldDB; A2T711; -.
DR SMR; A2T711; -.
DR STRING; 9598.ENSPTRP00000017466; -.
DR PaxDb; A2T711; -.
DR Ensembl; ENSPTRT00000018872; ENSPTRP00000017466; ENSPTRG00000010277.
DR GeneID; 468668; -.
DR KEGG; ptr:468668; -.
DR CTD; 84839; -.
DR VGNC; VGNC:2273; RAX2.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000163572; -.
DR HOGENOM; CLU_047013_4_0_1; -.
DR InParanoid; A2T711; -.
DR OMA; MFLSKCE; -.
DR OrthoDB; 1085093at2759; -.
DR TreeFam; TF315976; -.
DR Proteomes; UP000002277; Chromosome 19.
DR Bgee; ENSPTRG00000010277; Expressed in primary visual cortex and 5 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR036934; Homeobox_RAX2.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; PTHR46271; 1.
DR PANTHER; PTHR46271:SF2; PTHR46271:SF2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Sensory transduction;
KW Transcription; Transcription regulation; Vision.
FT CHAIN 1..184
FT /note="Retina and anterior neural fold homeobox protein 2"
FT /id="PRO_0000285528"
FT DNA_BIND 27..86
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 184 AA; 20104 MW; 2B2FC85C4A4DE062 CRC64;
MFLSPGEGPA TEGGGLGPGE EAPKKKHRRN RTTFTTYQLH QLERAFEASH YPDVYSREEL
AAKVHLPEVR VQVWFQNRRA KWRRQERLES GSGAVAAPRL PEAPALPFAR PPAMSLPLEP
WLGPGPPAVP GLPRLLGPGP GLQASFGPHA FAPTFADGFA LEEASLRLLA KEHAQAMDRA
WPPA
