RB11B_DICDI
ID RB11B_DICDI Reviewed; 220 AA.
AC Q54KM9; O43991;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Ras-related protein Rab-11B;
GN Name=rab11B; ORFNames=DDB_G0287211;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], DEVELOPMENTAL STAGE, AND DISRUPTION
RP PHENOTYPE.
RC STRAIN=AX3 / DH1;
RX PubMed=9632105;
RX DOI=10.1002/(sici)1097-4644(19980701)70:1<29::aid-jcb4>3.0.co;2-5;
RA Dragoi I.A., O'Halloran T.J.;
RT "Cloning and characterization of a Dictyostelium gene encoding a small
RT GTPase of the Rab11 family.";
RL J. Cell. Biochem. 70:29-37(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at uniform levels throughout growth and
CC development. {ECO:0000269|PubMed:9632105}.
CC -!- DISRUPTION PHENOTYPE: Mutants exhibit normal growth and development,
CC and endocytosis and the structure of membrane-bound organelles is
CC unaffected. {ECO:0000269|PubMed:9632105}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF037357; AAB92559.1; -; Genomic_DNA.
DR EMBL; AAFI02000099; EAL63807.1; -; Genomic_DNA.
DR RefSeq; XP_637328.1; XM_632236.1.
DR AlphaFoldDB; Q54KM9; -.
DR SMR; Q54KM9; -.
DR STRING; 44689.DDB0191421; -.
DR PaxDb; Q54KM9; -.
DR PRIDE; Q54KM9; -.
DR EnsemblProtists; EAL63807; EAL63807; DDB_G0287211.
DR GeneID; 8626026; -.
DR KEGG; ddi:DDB_G0287211; -.
DR dictyBase; DDB_G0287211; rab11B.
DR eggNOG; KOG0087; Eukaryota.
DR HOGENOM; CLU_041217_23_2_1; -.
DR InParanoid; Q54KM9; -.
DR OMA; HEQRTVF; -.
DR PhylomeDB; Q54KM9; -.
DR PRO; PR:Q54KM9; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0045335; C:phagocytic vesicle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; ISS:UniProtKB.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; ISS:UniProtKB.
DR GO; GO:0006895; P:Golgi to endosome transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0090387; P:phagolysosome assembly involved in apoptotic cell clearance; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; ISS:UniProtKB.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW Prenylation; Protein transport; Reference proteome; Transport.
FT CHAIN 1..220
FT /note="Ras-related protein Rab-11B"
FT /id="PRO_0000312421"
FT MOTIF 40..48
FT /note="Effector region"
FT /evidence="ECO:0000250"
FT BINDING 18..25
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 66..70
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 124..127
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 219
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 220
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 220 AA; 25335 MW; CCE7B54CAA06D04E CRC64;
MVLKTIEYDY LCKIVVIGDS GVGKSNLLSR YNKNEFSVGK LSTIGVEFST KTLKIDNKLI
KLQLWDTAGQ EKYNSITESY YKGAIGALIV YNIADRNSFN NLEKWLKKFR ENAHQDYGIM
LVGNKSDLKE YREVSTLEGK QFAEKHYMQF IETSALDSNN VETAFNNLFN FIYYSLFKNK
TMTLDINNNG NNNSNIMVGD CEPIQFDQRY TINKPVYDCC
