RB33A_HUMAN
ID RB33A_HUMAN Reviewed; 237 AA.
AC Q14088; Q5JUZ6; Q92465;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 2.
DT 03-AUG-2022, entry version 190.
DE RecName: Full=Ras-related protein Rab-33A;
DE AltName: Full=Small GTP-binding protein S10;
GN Name=RAB33A; Synonyms=RABS10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7688322; DOI=10.1016/0014-5793(93)80957-v;
RA Koda T., Kakinuma M.;
RT "Molecular cloning of a cDNA encoding a novel small GTP-binding protein.";
RL FEBS Lett. 328:21-24(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RA Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
RT "cDNA clones of human proteins involved in signal transduction sequenced by
RT the Guthrie cDNA resource center (www.cdna.org).";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q14088; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-744685, EBI-714543;
CC Q14088; Q676U5: ATG16L1; NbExp=3; IntAct=EBI-744685, EBI-535909;
CC Q14088; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-744685, EBI-10171416;
CC Q14088; Q15323: KRT31; NbExp=3; IntAct=EBI-744685, EBI-948001;
CC Q14088; O76011: KRT34; NbExp=3; IntAct=EBI-744685, EBI-1047093;
CC Q14088; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-744685, EBI-739832;
CC Q14088; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-744685, EBI-18273118;
CC Q14088; Q92530: PSMF1; NbExp=3; IntAct=EBI-744685, EBI-945916;
CC Q14088; Q9UI14: RABAC1; NbExp=3; IntAct=EBI-744685, EBI-712367;
CC Q14088; Q8WXA3-4: RUFY2; NbExp=3; IntAct=EBI-744685, EBI-19117969;
CC Q14088; Q7L099: RUFY3; NbExp=5; IntAct=EBI-744685, EBI-722392;
CC Q14088; Q8IUQ4: SIAH1; NbExp=3; IntAct=EBI-744685, EBI-747107;
CC Q14088; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-744685, EBI-3957603;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed only in lymphoid cell lines.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; D14889; BAA03606.1; -; mRNA.
DR EMBL; AF498959; AAM21107.1; -; mRNA.
DR EMBL; BT007038; AAP35687.1; -; mRNA.
DR EMBL; AL139234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC001157; AAH01157.1; -; mRNA.
DR EMBL; BC009996; AAH09996.1; -; mRNA.
DR CCDS; CCDS14621.1; -.
DR PIR; S35058; S35058.
DR RefSeq; NP_004785.1; NM_004794.2.
DR AlphaFoldDB; Q14088; -.
DR SMR; Q14088; -.
DR BioGRID; 114764; 43.
DR IntAct; Q14088; 18.
DR MINT; Q14088; -.
DR STRING; 9606.ENSP00000257017; -.
DR iPTMnet; Q14088; -.
DR PhosphoSitePlus; Q14088; -.
DR BioMuta; RAB33A; -.
DR DMDM; 2500071; -.
DR EPD; Q14088; -.
DR jPOST; Q14088; -.
DR MassIVE; Q14088; -.
DR MaxQB; Q14088; -.
DR PaxDb; Q14088; -.
DR PeptideAtlas; Q14088; -.
DR PRIDE; Q14088; -.
DR ProteomicsDB; 59807; -.
DR Antibodypedia; 30163; 141 antibodies from 27 providers.
DR DNASU; 9363; -.
DR Ensembl; ENST00000257017.5; ENSP00000257017.4; ENSG00000134594.5.
DR GeneID; 9363; -.
DR KEGG; hsa:9363; -.
DR MANE-Select; ENST00000257017.5; ENSP00000257017.4; NM_004794.3; NP_004785.1.
DR UCSC; uc004evl.4; human.
DR CTD; 9363; -.
DR DisGeNET; 9363; -.
DR GeneCards; RAB33A; -.
DR HGNC; HGNC:9773; RAB33A.
DR HPA; ENSG00000134594; Tissue enhanced (brain, choroid plexus).
DR MalaCards; RAB33A; -.
DR MIM; 300333; gene.
DR neXtProt; NX_Q14088; -.
DR OpenTargets; ENSG00000134594; -.
DR PharmGKB; PA34124; -.
DR VEuPathDB; HostDB:ENSG00000134594; -.
DR eggNOG; KOG0084; Eukaryota.
DR GeneTree; ENSGT00940000160863; -.
DR HOGENOM; CLU_041217_10_3_1; -.
DR InParanoid; Q14088; -.
DR OMA; ALEPYVQ; -.
DR OrthoDB; 1081271at2759; -.
DR PhylomeDB; Q14088; -.
DR TreeFam; TF300097; -.
DR PathwayCommons; Q14088; -.
DR Reactome; R-HSA-8854214; TBC/RABGAPs.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; Q14088; -.
DR BioGRID-ORCS; 9363; 9 hits in 694 CRISPR screens.
DR ChiTaRS; RAB33A; human.
DR GeneWiki; RAB33A; -.
DR GenomeRNAi; 9363; -.
DR Pharos; Q14088; Tbio.
DR PRO; PR:Q14088; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q14088; protein.
DR Bgee; ENSG00000134594; Expressed in cortical plate and 135 other tissues.
DR Genevisible; Q14088; HS.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019882; P:antigen processing and presentation; IMP:UniProtKB.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR CDD; cd04115; Rab33B_Rab33A; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041822; Rab33A/B.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..237
FT /note="Ras-related protein Rab-33A"
FT /id="PRO_0000121237"
FT BINDING 43..50
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 91..95
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 151..154
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 237
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 235
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 237
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT VARIANT 102
FT /note="M -> T"
FT /id="VAR_006849"
SQ SEQUENCE 237 AA; 26593 MW; 2EE23B8237225F4A CRC64;
MAQPILGHGS LQPASAAGLA SLELDSSLDQ YVQIRIFKII VIGDSNVGKT CLTFRFCGGT
FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK SMVEHYYRNV HAVVFVYDVT
KMTSFTNLKM WIQECNGHAV PPLVPKVLVG NKCDLREQIQ VPSNLALKFA DAHNMLLFET
SAKDPKESQN VESIFMCLAC RLKAQKSLLY RDAERQQGKV QKLEFPQEAN SKTSCPC
