RB33A_MOUSE
ID RB33A_MOUSE Reviewed; 237 AA.
AC P97950;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Ras-related protein Rab-33A;
DE AltName: Full=Small GTP-binding protein S10;
GN Name=Rab33a; Synonyms=Rabs10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Brain;
RX PubMed=9116044; DOI=10.1016/s0167-4781(97)00022-5;
RA Zheng J.Y., Koda T., Arimura Y., Kishi M., Kakinuma M.;
RT "Structure and expression of the mouse S10 gene.";
RL Biochim. Biophys. Acta 1351:47-50(1997).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in brain. Weak expression
CC in ovary.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; D83279; BAA11883.1; -; mRNA.
DR EMBL; D83277; BAA11882.1; -; Genomic_DNA.
DR CCDS; CCDS30110.1; -.
DR RefSeq; NP_035358.1; NM_011228.2.
DR AlphaFoldDB; P97950; -.
DR SMR; P97950; -.
DR IntAct; P97950; 9.
DR STRING; 10090.ENSMUSP00000033430; -.
DR iPTMnet; P97950; -.
DR PhosphoSitePlus; P97950; -.
DR PaxDb; P97950; -.
DR PeptideAtlas; P97950; -.
DR PRIDE; P97950; -.
DR ProteomicsDB; 254992; -.
DR Antibodypedia; 30163; 141 antibodies from 27 providers.
DR DNASU; 19337; -.
DR Ensembl; ENSMUST00000033430; ENSMUSP00000033430; ENSMUSG00000031104.
DR GeneID; 19337; -.
DR KEGG; mmu:19337; -.
DR UCSC; uc009tci.2; mouse.
DR CTD; 9363; -.
DR MGI; MGI:109493; Rab33a.
DR VEuPathDB; HostDB:ENSMUSG00000031104; -.
DR eggNOG; KOG0084; Eukaryota.
DR GeneTree; ENSGT00940000160863; -.
DR HOGENOM; CLU_041217_10_3_1; -.
DR InParanoid; P97950; -.
DR OMA; ALEPYVQ; -.
DR OrthoDB; 1081271at2759; -.
DR PhylomeDB; P97950; -.
DR TreeFam; TF300097; -.
DR Reactome; R-MMU-8854214; TBC/RABGAPs.
DR Reactome; R-MMU-8873719; RAB geranylgeranylation.
DR BioGRID-ORCS; 19337; 2 hits in 73 CRISPR screens.
DR ChiTaRS; Rab33a; mouse.
DR PRO; PR:P97950; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; P97950; protein.
DR Bgee; ENSMUSG00000031104; Expressed in superior cervical ganglion and 150 other tissues.
DR ExpressionAtlas; P97950; baseline and differential.
DR Genevisible; P97950; MM.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0019882; P:antigen processing and presentation; ISO:MGI.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR CDD; cd04115; Rab33B_Rab33A; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041822; Rab33A/B.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Methylation;
KW Nucleotide-binding; Prenylation; Reference proteome.
FT CHAIN 1..237
FT /note="Ras-related protein Rab-33A"
FT /id="PRO_0000121238"
FT BINDING 43..50
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 91..95
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 151..154
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 237
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 235
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 237
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 237 AA; 26541 MW; 6EF2E03B5E239930 CRC64;
MAQPILGHGS LQPASAAGLA SLELDSSMDQ YVQIRIFKII VIGDSNVGKT CLTFRFCGGT
FPDKTEATIG VDFREKTVEI EGEKIKVQVW DTAGQERFRK SMVEHYYRNV HAVVFVYDVT
KMTSFTNLKM WIQECNGHAV PPLVPKVLVG NKCDLREQIQ VPSNLALKFA DAHNMLLFET
SAKDPKESQN VESIFMCLAC RLKAQKSLLY RDAERQQGKV QKLEFSQEAN GKASCPC
