RB33B_CHICK
ID RB33B_CHICK Reviewed; 228 AA.
AC Q5ZHV1;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ras-related protein Rab-33B;
GN Name=RAB33B; ORFNames=RCJMB04_32p6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Protein transport. Acts, in coordination with RAB6A, to
CC regulate intra-Golgi retrograde trafficking (By similarity). It is
CC involved in autophagy, acting as a modulator of autophagosome formation
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:O35963}; Lipid-anchor {ECO:0000305}. Golgi
CC apparatus, cis-Golgi network {ECO:0000250|UniProtKB:O35963}. Note=Under
CC starvation conditions punctate RAB33B-positive structures are often
CC observed in the cytoplasm. {ECO:0000250|UniProtKB:O35963}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AJ721033; CAG32692.1; -; mRNA.
DR RefSeq; NP_001008466.1; NM_001008466.1.
DR AlphaFoldDB; Q5ZHV1; -.
DR SMR; Q5ZHV1; -.
DR STRING; 9031.ENSGALP00000015909; -.
DR PaxDb; Q5ZHV1; -.
DR PRIDE; Q5ZHV1; -.
DR Ensembl; ENSGALT00000015926; ENSGALP00000015909; ENSGALG00000009790.
DR GeneID; 422441; -.
DR KEGG; gga:422441; -.
DR CTD; 83452; -.
DR VEuPathDB; HostDB:geneid_422441; -.
DR eggNOG; KOG0084; Eukaryota.
DR GeneTree; ENSGT00940000157090; -.
DR HOGENOM; CLU_041217_10_3_1; -.
DR InParanoid; Q5ZHV1; -.
DR OMA; QQFADSH; -.
DR OrthoDB; 1081271at2759; -.
DR PhylomeDB; Q5ZHV1; -.
DR TreeFam; TF300097; -.
DR Reactome; R-GGA-6811438; Intra-Golgi traffic.
DR Reactome; R-GGA-8854214; TBC/RABGAPs.
DR PRO; PR:Q5ZHV1; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000009790; Expressed in muscle tissue and 13 other tissues.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0005796; C:Golgi lumen; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; ISS:UniProtKB.
DR GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:1903434; P:negative regulation of constitutive secretory pathway; IEA:Ensembl.
DR GO; GO:0034067; P:protein localization to Golgi apparatus; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032482; P:Rab protein signal transduction; IEA:InterPro.
DR GO; GO:0017157; P:regulation of exocytosis; IBA:GO_Central.
DR GO; GO:1903358; P:regulation of Golgi organization; IEA:Ensembl.
DR GO; GO:2000156; P:regulation of retrograde vesicle-mediated transport, Golgi to ER; ISS:UniProtKB.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR CDD; cd04115; Rab33B_Rab33A; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041822; Rab33A/B.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
PE 2: Evidence at transcript level;
KW Autophagy; Golgi apparatus; GTP-binding; Lipoprotein; Membrane;
KW Methylation; Nucleotide-binding; Prenylation; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..228
FT /note="Ras-related protein Rab-33B"
FT /id="PRO_0000261126"
FT BINDING 37..44
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 86..90
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 146..149
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT MOD_RES 228
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 226
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 228
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 228 AA; 25736 MW; F184179BF6CA609C CRC64;
MAAELESSLE LSFTGSGTVP GGGLPPARSR IFKIIVIGDS NVGKTCLTYR FCAGRFPQRT
EATIGVDFRE RAVTIDGERI KIQLWDTAGQ ERFRKSMVQH YYRNVHAVVF VYDMTNLASF
HSLPSWIEEC KQHLLTNDIP RILVGNKCDL RNAIQVPTDL AQKFADTHSM PLFETSAKNP
NDNDHVEAIF MTLAHKLKSH KPLMLSQPPD RDQIHIKPEP KPAMTCWC
