ID   RB3GP_CAEEL             Reviewed;         915 AA.
AC   Q93538;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Rab3 GTPase-activating protein catalytic subunit;
DE   AltName: Full=Rab3 GTPase-activating protein 1;
GN   Name=rbg-1; ORFNames=F20D1.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable catalytic subunit of a GTPase activating protein
CC       that has specificity for Rab3 subfamily. Rab3 proteins are involved in
CC       regulated exocytosis of neurotransmitters and hormones. Specifically
CC       converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The Rab3 GTPase-activating complex is a heterodimer composed
CC       of rbg-1 and rbg-2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Rab3-GAP catalytic subunit family.
CC       {ECO:0000305}.
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DR   EMBL; Z78542; CAB01748.1; -; Genomic_DNA.
DR   PIR; T21147; T21147.
DR   RefSeq; NP_510490.1; NM_078089.3.
DR   AlphaFoldDB; Q93538; -.
DR   BioGRID; 46492; 3.
DR   STRING; 6239.F20D1.6; -.
DR   EPD; Q93538; -.
DR   PaxDb; Q93538; -.
DR   PeptideAtlas; Q93538; -.
DR   EnsemblMetazoa; F20D1.6.1; F20D1.6.1; WBGene00004317.
DR   GeneID; 181595; -.
DR   KEGG; cel:CELE_F20D1.6; -.
DR   UCSC; F20D1.6.1; c. elegans.
DR   CTD; 181595; -.
DR   WormBase; F20D1.6; CE09499; WBGene00004317; rbg-1.
DR   eggNOG; KOG2390; Eukaryota.
DR   GeneTree; ENSGT00390000006705; -.
DR   HOGENOM; CLU_012561_1_0_1; -.
DR   InParanoid; Q93538; -.
DR   OMA; ADFLRWH; -.
DR   OrthoDB; 536022at2759; -.
DR   PhylomeDB; Q93538; -.
DR   Reactome; R-CEL-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR   Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q93538; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004317; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; ISS:UniProtKB.
DR   GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB.
DR   GO; GO:1990000; P:amyloid fibril formation; IMP:GO_Central.
DR   GO; GO:0006914; P:autophagy; IMP:WormBase.
DR   GO; GO:2000786; P:positive regulation of autophagosome assembly; IMP:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.
DR   InterPro; IPR045700; Rab3GAP1.
DR   InterPro; IPR026147; Rab3GAP1_conserved.
DR   PANTHER; PTHR21422; PTHR21422; 1.
DR   Pfam; PF13890; Rab3-GTPase_cat; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..915
FT                   /note="Rab3 GTPase-activating protein catalytic subunit"
FT                   /id="PRO_0000191660"
SQ   SEQUENCE   915 AA;  104585 MW;  0AEAFA63A58F8566 CRC64;
     MAEIEENTVF EINDFTIVTD MEHFGAAFEG ILQKYEFSSR RPCLSNDVKY RLIVTDTNMI
     SIGENKLRIE LLQPVPASSN PSNDVEFVEA PKDEIEEDAH VIPFTVAEEV ANLKHGFEVT
     DSFLLKFGIR ECIIISPNDS SGTFTDENQV NTVMGNIKTI LHSSRCEVPV FCYIKDQSLD
     MISGYASDGN STYNFSSVVL RNINRRHCSM TDLLYLFKEH LGASISAFHE EVRMSSRFTH
     VVPLKQSKYF RNHTVETFGL LATGPTSSLP FDILEIAATW RFFRENSLTE NHSHSDFDIN
     YSSYWNIKMK STKSSLLGVL DEILGVYRED TRKAIRSDLN CALILGKHYT QKELPNAFQK
     LTINSASEVK IGKHAETEDS GTNGPMPPAL MKSWVNFIFN EAESDNESLA HELNMLNAAS
     MSENQLSDDE LVNNVKLDTL FNYKNPKSAN TFLAPYKCAK KSTVTWRLAI ALANARVFMS
     DQPRAEPQLW VEFLLKLREK YEKMETVEKV YNGIDHLQCS FSQKMQMLQL CIDARQKRHR
     MLDSAHSANN SDEFFDANES FNAETILEPN NEGRLKLFGL NLVEIPDVPM YIPVTQDACP
     LTDEMIDARN EHLFSLDEED RVHLQMELVK SDMQSFKAAN AGAVFADFLR WHSPKDYDEK
     TNTISERMLI SNNVWVRSWE AALPIPVANQ ARIFNDTKIA EEILEIFNNA TLDQVREWMK
     PTVFAATLER LTEIESSYGV SEEKQKQRTK TAKILANATL NNTPMDYNEI SKYCSQIEMI
     HNMKVHLMQL FENAREKMHP PYPSETDVQS AIKQLVNIAV HNLWDNSTDE EPTFVIKPQD
     PIGRAIAVIG KLDELTEQQL INGHRKEYIF NWKHSCPSTT TIPMTHRMYA DLRSDKHSLY
     FSMANDCNFS NSSYL