ID   RB3GP_DANRE             Reviewed;         969 AA.
AC   Q6NUV0;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Rab3 GTPase-activating protein catalytic subunit;
GN   Name=rab3gap1; Synonyms=rab3gap; ORFNames=wu:fj56a04;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-969.
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable catalytic subunit of a GTPase activating protein
CC       that has specificity for Rab3 subfamily. Rab3 proteins are involved in
CC       regulated exocytosis of neurotransmitters and hormones. Specifically
CC       converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The Rab3 GTPase-activating complex is a heterodimer composed
CC       of rab3gap and rab3gap150. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Rab3-GAP catalytic subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC068420; AAH68420.1; -; mRNA.
DR   RefSeq; NP_001071256.2; NM_001077788.2.
DR   AlphaFoldDB; Q6NUV0; -.
DR   STRING; 7955.ENSDARP00000108106; -.
DR   PaxDb; Q6NUV0; -.
DR   PRIDE; Q6NUV0; -.
DR   GeneID; 777744; -.
DR   KEGG; dre:777744; -.
DR   CTD; 22930; -.
DR   ZFIN; ZDB-GENE-061027-53; rab3gap1.
DR   eggNOG; KOG2390; Eukaryota.
DR   InParanoid; Q6NUV0; -.
DR   OrthoDB; 536022at2759; -.
DR   PhylomeDB; Q6NUV0; -.
DR   Reactome; R-DRE-6811436; COPI-independent Golgi-to-ER retrograde traffic.
DR   Reactome; R-DRE-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q6NUV0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR045700; Rab3GAP1.
DR   InterPro; IPR045698; Rab3GAP1_C.
DR   InterPro; IPR026147; Rab3GAP1_conserved.
DR   PANTHER; PTHR21422; PTHR21422; 1.
DR   Pfam; PF19533; Rab3-GAP_cat_C; 1.
DR   Pfam; PF13890; Rab3-GTPase_cat; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..969
FT                   /note="Rab3 GTPase-activating protein catalytic subunit"
FT                   /id="PRO_0000191658"
FT   REGION          532..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        532..551
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..608
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   969 AA;  108621 MW;  8CF5611FCF2747C1 CRC64;
     MAADSDPESE VFEITDFTTA SEWERFISRV EEVLNDWKLI GSRVGKPLEK GEYTSGTWEE
     SSQEISFADF KFSITHHYLK QESAENDGRD ELEEDAYPLA MQDLLCINND FPPRAHCLVR
     WFGVREFVVI SPGANCEAII SESKCSLLLS SVSIALANTG CQVPLFVQIQ QKHRKMFSGE
     CQGPGVRSDF EMVHLRRVPS QYNHLSGLLD IFKNKIGCPL TPLPPINISI RFTYVLQDWQ
     QCSWPQQPPD FDALLAGEVG GVEFGKLPFG ACEDPISELH LAATWPSLTE GIVVDNDVYS
     DLDPLQAPHW SVRVRTAENP QCLLGEFLTE FFKICCRKET TEEILGRSTA EEEGKENSDI
     TQALSKLTEP STAVPIHKLS VSSMVHSARK RIRRHRRVPE SPLNNDVLNS ILLYLFPDAA
     LDKADVSEVR PPQQSPDRQS EDYHLYNQLK SCPSDSLTHR LALCICMVNF HHGGVRAVAH
     LWQEFVLEMR YRWENNCLIY GLASGPPDLR CCLLHQKLQM LNCCIERKKA RDDGKKSSSS
     DGARDRSRGA PEGAGPEGAG PAEAAGKSWD SWSDSEDEFF ECVSDTEEMK EDKEEAENRS
     RSKPEGRLQP HGTHTLLNTQ EPLYIPITQE PAPMTEDLLE EQSEVLAKLG TSAEGAHLRA
     RMQSACLLSD MESFKAANPG CTLLDFVRWY SPRDYVEEQV TDADGRVEVR GELSARMKIP
     GNMWVEAWET ARATPARRQK RLFDDTKEAE KVLHYLALQK PSELTRHLLP CVLHAALLKI
     KEEESAEDLP SVRSSLQQIS SSASKILRHP NPEFKKLEDV ISQLMAVEAV IARARSLKAK
     FGVCGGERER EEDGDELERF VSSLLEEPEV CVSGAGRGPA GNVIHKLFVS SQRAALLAPM
     EEETLRSGGS DDRKAFPDFP PPAGREILLR TCVPRPAPYS KALPQRLFCV LMRDEFRLAG
     AFSSDTSFF