ID   RB3GP_XENLA             Reviewed;         978 AA.
AC   Q642R9;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Rab3 GTPase-activating protein catalytic subunit;
GN   Name=rab3gap1; Synonyms=rab3gap;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable catalytic subunit of a GTPase activating protein
CC       that has specificity for Rab3 subfamily. Rab3 proteins are involved in
CC       regulated exocytosis of neurotransmitters and hormones. Specifically
CC       converts active Rab3-GTP to the inactive form Rab3-GDP (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The Rab3 GTPase-activating complex is a heterodimer composed
CC       of RAB3GAP and RAB3GAP150. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the Rab3-GAP catalytic subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC081089; AAH81089.1; -; mRNA.
DR   RefSeq; NP_001087691.1; NM_001094222.1.
DR   AlphaFoldDB; Q642R9; -.
DR   SMR; Q642R9; -.
DR   DNASU; 447515; -.
DR   GeneID; 447515; -.
DR   KEGG; xla:447515; -.
DR   CTD; 447515; -.
DR   Xenbase; XB-GENE-995564; rab3gap1.L.
DR   OrthoDB; 536022at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 447515; Expressed in brain and 20 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IEA:InterPro.
DR   InterPro; IPR045700; Rab3GAP1.
DR   InterPro; IPR045698; Rab3GAP1_C.
DR   InterPro; IPR026147; Rab3GAP1_conserved.
DR   PANTHER; PTHR21422; PTHR21422; 1.
DR   Pfam; PF19533; Rab3-GAP_cat_C; 1.
DR   Pfam; PF13890; Rab3-GTPase_cat; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; GTPase activation; Reference proteome.
FT   CHAIN           1..978
FT                   /note="Rab3 GTPase-activating protein catalytic subunit"
FT                   /id="PRO_0000191659"
FT   REGION          533..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          586..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          908..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        539..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..615
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   978 AA;  109800 MW;  E827C8587ABAD3D8 CRC64;
     MAADSDPESE VFEITDFTTA SEWERFISKV EEVLTEWKLI GETSNKPPEK GEYTSGVWEE
     KGEEVLFADF RFSIRHHYLV QKSSEKEEKE DTGEDSIPVC MQDLLCTNND FPPVAHCLVR
     WYGLREFVVI SPGANDAVIS ESKCNLLLSS VSIALGNTGC QVPLFVQVHQ KWRKLYVGEC
     RGPGVRTDFE MVHLRKVPNQ YTHLSGLLDI FKSKIGCPLT ALPPVNIAIR FTYVLQDWQQ
     YFWPQQPPDI DALIGGEVGG LEFGKLPFGA CEDPISELHL ATTWPCLTEG IIVDNDVYSD
     LDPLQAPQWS VRVRKADNPQ CMLGDFVSEF FRLCRRKEST DELLGKSAFE ENGKEGADIS
     QALSKLTEPA PVPIHKLSVT SMVHSARKKI RKHRGADESP LNNDVLNAIL FFLFPDTKSL
     DGSEAKPSTS TGNISSQSES EDYNLYSQLK SAPSNSLTYK LALCLCMVNF YHGGVKGVAH
     LWQEFVLEMR YRWENNFLIP GLANGSPDLK CCLLHQKLQM LNCCLERKKA RDEGKKGNPL
     YSSSESSVNK TASDLLSPVE ADKSKYEVAK SWDSWSDSEE EFFECHSDTE ELKESGQESA
     RKAKEETKEN PSPKPEGRLH QSGNLMLLNS GEPLYIPVTQ DPAPMTDDLL EEQSEVLAKL
     GTSAEGAHLR ARMQSACLLS DMESFKAANP GCCLEDFVRW YSPRDYIEEE VMDDKGNKIF
     KGELSARMKI PNNMWVEAWE TAKPIPARRQ RRLFDDTKEA EKVLHYLAVQ KPADLTRHLL
     PCVIHAALLK LKEEEAAEDI PSGRKAIKQI ISHSSKVLRF PSPDDKKLED VISQISNVEA
     AIARARSLKA KFAIDRCEKS EEREDLEKFV SCLLDQPEVP IIGAGRGAAG TIIHKMFVQR
     ALTLAPVEEE PKRSSSSDDR RQTSGTDFPS PAGRELILRT SVPRPAPYSK VLPQRMYSVL
     TKEDFRLTGA FSSDTSFF