RB40B_HUMAN
ID RB40B_HUMAN Reviewed; 278 AA.
AC Q12829; Q8WVG3;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 185.
DE RecName: Full=Ras-related protein Rab-40B;
DE AltName: Full=SOCS box-containing protein RAR;
DE Short=Protein Rar;
GN Name=RAB40B; Synonyms=SEC4L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hippocampus;
RA Peng H., Lee J., Chang H.;
RT "Characterization of a human hippocampus cDNA clone encoding a novel SEC-4
RT like protein.";
RL Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be a substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which
CC mediates the ubiquitination and subsequent proteasomal degradation of
CC target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- INTERACTION:
CC Q12829; O95967: EFEMP2; NbExp=3; IntAct=EBI-3915431, EBI-743414;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; U05227; AAA17031.1; -; mRNA.
DR EMBL; BC018039; AAH18039.1; -; mRNA.
DR CCDS; CCDS11816.1; -.
DR PIR; G01251; G01251.
DR RefSeq; NP_006813.1; NM_006822.2.
DR AlphaFoldDB; Q12829; -.
DR SMR; Q12829; -.
DR BioGRID; 116165; 31.
DR IntAct; Q12829; 10.
DR STRING; 9606.ENSP00000461785; -.
DR iPTMnet; Q12829; -.
DR PhosphoSitePlus; Q12829; -.
DR BioMuta; RAB40B; -.
DR DMDM; 27734453; -.
DR EPD; Q12829; -.
DR MassIVE; Q12829; -.
DR PaxDb; Q12829; -.
DR PeptideAtlas; Q12829; -.
DR PRIDE; Q12829; -.
DR ProteomicsDB; 58972; -.
DR Antibodypedia; 33036; 159 antibodies from 27 providers.
DR DNASU; 10966; -.
DR Ensembl; ENST00000571995.6; ENSP00000461785.1; ENSG00000141542.11.
DR GeneID; 10966; -.
DR KEGG; hsa:10966; -.
DR MANE-Select; ENST00000571995.6; ENSP00000461785.1; NM_006822.3; NP_006813.1.
DR UCSC; uc002kft.4; human.
DR CTD; 10966; -.
DR DisGeNET; 10966; -.
DR GeneCards; RAB40B; -.
DR HGNC; HGNC:18284; RAB40B.
DR HPA; ENSG00000141542; Tissue enhanced (brain).
DR MIM; 619550; gene.
DR neXtProt; NX_Q12829; -.
DR OpenTargets; ENSG00000141542; -.
DR PharmGKB; PA34138; -.
DR VEuPathDB; HostDB:ENSG00000141542; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000161207; -.
DR HOGENOM; CLU_041217_11_0_1; -.
DR InParanoid; Q12829; -.
DR OMA; HKRNSFR; -.
DR OrthoDB; 1065856at2759; -.
DR PhylomeDB; Q12829; -.
DR TreeFam; TF323230; -.
DR PathwayCommons; Q12829; -.
DR Reactome; R-HSA-8873719; RAB geranylgeranylation.
DR SignaLink; Q12829; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 10966; 13 hits in 1082 CRISPR screens.
DR ChiTaRS; RAB40B; human.
DR GenomeRNAi; 10966; -.
DR Pharos; Q12829; Tbio.
DR PRO; PR:Q12829; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q12829; protein.
DR Bgee; ENSG00000141542; Expressed in medial globus pallidus and 202 other tissues.
DR ExpressionAtlas; Q12829; baseline and differential.
DR Genevisible; Q12829; HS.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IDA:ParkinsonsUK-UCL.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:ParkinsonsUK-UCL.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:1901998; P:toxin transport; IMP:ParkinsonsUK-UCL.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW Palmitate; Prenylation; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..278
FT /note="Ras-related protein Rab-40B"
FT /id="PRO_0000121259"
FT DOMAIN 175..228
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 242..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 21..28
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 69..73
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 270
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 275
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
FT CONFLICT 42
FT /note="P -> T (in Ref. 2; AAH18039)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 30956 MW; 8AC3CD180C0CCA2C CRC64;
MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG
RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP
KILVGNRLHL AFKRQVPTEQ AQAYAERLGV TFFEVSPLCN FNITESFTEL ARIVLLRHGM
DRLWRPSKVL SLQDLCCRAV VSCTPVHLVD KLPLPIALRS HLKSFSMANG LNARMMHGGS
YSLTTSSTHK RSSLRKVKLV RPPQSPPKNC TRNSCKIS
