RB40C_MOUSE
ID RB40C_MOUSE Reviewed; 281 AA.
AC Q8VHQ4;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Ras-related protein Rab-40C;
DE AltName: Full=SOCS box-containing protein RAR3;
GN Name=Rab40c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Kile B.T., Hilton D.J., Nicola N.A.;
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probable substrate-recognition component of a SCF-like ECS
CC (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which
CC mediates the ubiquitination and subsequent proteasomal degradation of
CC target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the probable SCF-like ECS(RAB40C) E3 ubiquitin-
CC protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC
CC complex and RAB40C. Interacts with CUL5, RNF7, ELOB and ELOC (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
CC {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
CC -!- DOMAIN: The SOCS box domain mediates the interaction with the Elongin
CC BC complex, an adapter module in different E3 ubiquitin ligase
CC complexes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AF422144; AAL60515.1; -; mRNA.
DR EMBL; BC027008; AAH27008.1; -; mRNA.
DR CCDS; CCDS28537.1; -.
DR RefSeq; NP_631893.1; NM_139154.2.
DR AlphaFoldDB; Q8VHQ4; -.
DR SMR; Q8VHQ4; -.
DR BioGRID; 230291; 1.
DR IntAct; Q8VHQ4; 17.
DR MINT; Q8VHQ4; -.
DR STRING; 10090.ENSMUSP00000127546; -.
DR iPTMnet; Q8VHQ4; -.
DR PhosphoSitePlus; Q8VHQ4; -.
DR MaxQB; Q8VHQ4; -.
DR PaxDb; Q8VHQ4; -.
DR PRIDE; Q8VHQ4; -.
DR ProteomicsDB; 300251; -.
DR Antibodypedia; 35310; 136 antibodies from 24 providers.
DR DNASU; 224624; -.
DR Ensembl; ENSMUST00000026826; ENSMUSP00000026826; ENSMUSG00000025730.
DR Ensembl; ENSMUST00000167626; ENSMUSP00000127546; ENSMUSG00000025730.
DR Ensembl; ENSMUST00000179998; ENSMUSP00000136612; ENSMUSG00000025730.
DR GeneID; 224624; -.
DR KEGG; mmu:224624; -.
DR UCSC; uc008bco.2; mouse.
DR CTD; 57799; -.
DR MGI; MGI:2183454; Rab40c.
DR VEuPathDB; HostDB:ENSMUSG00000025730; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000158979; -.
DR HOGENOM; CLU_041217_11_0_1; -.
DR InParanoid; Q8VHQ4; -.
DR OMA; RMAFFEV; -.
DR OrthoDB; 1065856at2759; -.
DR PhylomeDB; Q8VHQ4; -.
DR TreeFam; TF323230; -.
DR Reactome; R-MMU-8873719; RAB geranylgeranylation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 224624; 5 hits in 72 CRISPR screens.
DR ChiTaRS; Rab40c; mouse.
DR PRO; PR:Q8VHQ4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8VHQ4; protein.
DR Bgee; ENSMUSG00000025730; Expressed in dorsal pancreas and 254 other tissues.
DR ExpressionAtlas; Q8VHQ4; baseline and differential.
DR Genevisible; Q8VHQ4; MM.
DR GO; GO:0005768; C:endosome; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005811; C:lipid droplet; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0019003; F:GDP binding; ISO:MGI.
DR GO; GO:0005525; F:GTP binding; ISO:MGI.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00174; RHO; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF158235; SSF158235; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR TIGRFAMs; TIGR00231; small_GTP; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 1: Evidence at protein level;
KW Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW Palmitate; Prenylation; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..281
FT /note="Ras-related protein Rab-40C"
FT /id="PRO_0000121262"
FT DOMAIN 175..228
FT /note="SOCS box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00194"
FT REGION 245..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 21..28
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 69..73
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 126..129
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT LIPID 273
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000255"
FT LIPID 278
FT /note="S-geranylgeranyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 281 AA; 31348 MW; 3625546777BA90A8 CRC64;
MGTQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG
RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP
RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM
EKIWRPNRVF SLQDLCCRAI VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS
YSLASGAGGS GSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S
