RB8NL_HUMAN
ID RB8NL_HUMAN Reviewed; 664 AA.
AC Q8NC74; B2RP98; Q8N4Z9; Q9BR75; Q9H0Y9;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 3.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=RBBP8 N-terminal-like protein;
GN Name=RBBP8NL; Synonyms=C20orf151;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-348 AND ARG-637.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8NC74; O15145: ARPC3; NbExp=3; IntAct=EBI-11322432, EBI-351829;
CC Q8NC74; Q9BZP6: CHIA; NbExp=3; IntAct=EBI-11322432, EBI-14357960;
CC Q8NC74; P56545-3: CTBP2; NbExp=3; IntAct=EBI-11322432, EBI-10171902;
CC Q8NC74; Q9H6Z9: EGLN3; NbExp=3; IntAct=EBI-11322432, EBI-1175354;
CC Q8NC74; Q659C4-6: LARP1B; NbExp=3; IntAct=EBI-11322432, EBI-12036449;
CC Q8NC74; O43639: NCK2; NbExp=3; IntAct=EBI-11322432, EBI-713635;
CC Q8NC74; O43189: PHF1; NbExp=3; IntAct=EBI-11322432, EBI-530034;
CC Q8NC74; Q13526: PIN1; NbExp=3; IntAct=EBI-11322432, EBI-714158;
CC Q8NC74; Q9BUI4: POLR3C; NbExp=3; IntAct=EBI-11322432, EBI-5452779;
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DR EMBL; AK074919; BAC11293.1; -; mRNA.
DR EMBL; AL121832; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006450; AAH06450.1; -; mRNA.
DR EMBL; BC033142; AAH33142.2; -; mRNA.
DR EMBL; BC137326; AAI37327.1; -; mRNA.
DR EMBL; BC137327; AAI37328.1; -; mRNA.
DR CCDS; CCDS13498.1; -.
DR RefSeq; NP_543023.2; NM_080833.2.
DR AlphaFoldDB; Q8NC74; -.
DR SMR; Q8NC74; -.
DR BioGRID; 126756; 11.
DR IntAct; Q8NC74; 10.
DR MINT; Q8NC74; -.
DR STRING; 9606.ENSP00000252998; -.
DR iPTMnet; Q8NC74; -.
DR PhosphoSitePlus; Q8NC74; -.
DR BioMuta; RBBP8NL; -.
DR DMDM; 60416376; -.
DR jPOST; Q8NC74; -.
DR MassIVE; Q8NC74; -.
DR MaxQB; Q8NC74; -.
DR PaxDb; Q8NC74; -.
DR PeptideAtlas; Q8NC74; -.
DR PRIDE; Q8NC74; -.
DR ProteomicsDB; 72860; -.
DR Antibodypedia; 48245; 40 antibodies from 8 providers.
DR DNASU; 140893; -.
DR Ensembl; ENST00000252998.2; ENSP00000252998.1; ENSG00000130701.4.
DR GeneID; 140893; -.
DR KEGG; hsa:140893; -.
DR MANE-Select; ENST00000252998.2; ENSP00000252998.1; NM_080833.3; NP_543023.2.
DR UCSC; uc002ycw.3; human.
DR CTD; 140893; -.
DR GeneCards; RBBP8NL; -.
DR HGNC; HGNC:16144; RBBP8NL.
DR HPA; ENSG00000130701; Tissue enhanced (esophagus).
DR neXtProt; NX_Q8NC74; -.
DR OpenTargets; ENSG00000130701; -.
DR PharmGKB; PA25693; -.
DR VEuPathDB; HostDB:ENSG00000130701; -.
DR eggNOG; ENOG502RTF0; Eukaryota.
DR GeneTree; ENSGT00530000063835; -.
DR HOGENOM; CLU_027960_0_0_1; -.
DR InParanoid; Q8NC74; -.
DR OMA; HENEVMG; -.
DR OrthoDB; 567214at2759; -.
DR PhylomeDB; Q8NC74; -.
DR TreeFam; TF336239; -.
DR PathwayCommons; Q8NC74; -.
DR SignaLink; Q8NC74; -.
DR BioGRID-ORCS; 140893; 17 hits in 1068 CRISPR screens.
DR ChiTaRS; RBBP8NL; human.
DR GenomeRNAi; 140893; -.
DR Pharos; Q8NC74; Tdark.
DR PRO; PR:Q8NC74; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8NC74; protein.
DR Bgee; ENSG00000130701; Expressed in lower esophagus mucosa and 92 other tissues.
DR Genevisible; Q8NC74; HS.
DR GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR InterPro; IPR019518; CtIP_N.
DR InterPro; IPR033316; RBBP8-like.
DR PANTHER; PTHR15107; PTHR15107; 1.
DR Pfam; PF10482; CtIP_N; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..664
FT /note="RBBP8 N-terminal-like protein"
FT /id="PRO_0000079470"
FT REGION 125..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 369..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..252
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..554
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..628
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 348
FT /note="D -> N (in dbSNP:rs3810553)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056849"
FT VARIANT 408
FT /note="A -> T (in dbSNP:rs10888228)"
FT /id="VAR_056850"
FT VARIANT 607
FT /note="E -> K (in dbSNP:rs6089366)"
FT /id="VAR_056851"
FT VARIANT 637
FT /note="L -> R (in dbSNP:rs2236200)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056852"
FT CONFLICT 127
FT /note="G -> V (in Ref. 1; BAC11293)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 664 AA; 71432 MW; AF74AE9E54CE88F8 CRC64;
MESFMESLNR LKEIHEKEVL GLQNKLLELN SERCRDAQRI EELFSKNHQL REQQKTLKEN
LRVLENRLRA GLCDRCMVTQ ELARKRQQEF ESSHLQNLQR IFILTNEMNG LKEENETLKE
EVKRLRGLGD RPKPRAKEGT SDPPSPLLLP SPGGWKAITE KPPGGHEEAE EDHQGVGLRG
EEKPAGHRTS PVAKISPGAT LPESRAPDMS PQRISNQLHG TIAVVRPGSQ ACPADRGPAN
GTPPPLPARS SPPSPAYERG LSLDSFLRAS RPSAMTHEAP KLSPKVDRLC LLNRPLSLHL
QSPHSSPLAP AAAPSDPRLQ DLKAREAEAW EEPTELLGLP SALAGMQDLR LEGALHLLLA
QQQLRARARA GSVRPRGQPT PGEMLPSLPV GSDSEGPENE GTRAALAAAG LSGGRHTQPA
GPGRAQRTEA AATQDCALDK PLDLSEWGRA RGQDTPKPAG QHGSLSPAAA HTASPEPPTQ
SGPLTRSPQA LSNGTKGTRV PEQEEASTPM DPSRPLPGSQ LSLSSPGSTE DEDTGRPLPP
PHPQPPPHPQ PPDLDGHPEP SKAEVLRPES DELDETDTPG SEVGLSSQAE ATTSTTGEGP
ECICTQEHGQ GPPRKRKRAS EPGDKASKKP SRGRRKLTAT EGPGSPRDAE DHSPSPNSSP
WEET
