RBA1_CAEEL
ID RBA1_CAEEL Reviewed; 412 AA.
AC P90917;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Probable histone-binding protein rba-1;
GN Name=rba-1 {ECO:0000312|WormBase:K07A1.11};
GN ORFNames=K07A1.11 {ECO:0000312|WormBase:K07A1.11};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION.
RX PubMed=10704416; DOI=10.1016/s0960-9822(00)00343-2;
RA Solari F., Ahringer J.;
RT "NURD-complex genes antagonise Ras-induced vulval development in
RT Caenorhabditis elegans.";
RL Curr. Biol. 10:223-226(2000).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=25446273; DOI=10.1016/j.ydbio.2014.10.014;
RA Krueger A.V., Jelier R., Dzyubachyk O., Zimmerman T., Meijering E.,
RA Lehner B.;
RT "Comprehensive single cell-resolution analysis of the role of chromatin
RT regulators in early C. elegans embryogenesis.";
RL Dev. Biol. 398:153-162(2015).
RN [4]
RP FUNCTION, AND INTERACTION WITH ZTF-11.
RX PubMed=31386623; DOI=10.7554/elife.46703;
RA Lee J., Taylor C.A., Barnes K.M., Shen A., Stewart E.V., Chen A.,
RA Xiang Y.K., Bao Z., Shen K.;
RT "A Myt1 family transcription factor defines neuronal fate by repressing
RT non-neuronal genes.";
RL Elife 8:0-0(2019).
CC -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC assembly factors, chromatin remodeling factors and histone deacetylases
CC to their histone substrates in a manner that is regulated by
CC nucleosomal DNA (By similarity). Plays a role in regulating cell cycle
CC progression (PubMed:25446273). Required to repress the induction of
CC vulval development by Ras signaling. In association with the zinc
CC finger protein ztf-11, negatively regulates the expression of non-
CC neuronal genes during neurogenesis (PubMed:31386623). {ECO:0000250,
CC ECO:0000269|PubMed:10704416, ECO:0000269|PubMed:25446273,
CC ECO:0000269|PubMed:31386623}.
CC -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC region that is not accessible when H4 is in chromatin (By similarity).
CC Interacts with zft-11; the interaction is required to suppress the
CC activation of non-neuronal genes in neurons (PubMed:31386623).
CC {ECO:0000250|UniProtKB:Q16576, ECO:0000269|PubMed:31386623}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown results in delayed cell
CC cycle progression. {ECO:0000269|PubMed:25446273}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; BX284601; CAB03172.1; -; Genomic_DNA.
DR PIR; T23385; T23385.
DR RefSeq; NP_492551.1; NM_060150.4.
DR AlphaFoldDB; P90917; -.
DR SMR; P90917; -.
DR BioGRID; 38226; 2.
DR IntAct; P90917; 1.
DR STRING; 6239.K07A1.11; -.
DR EPD; P90917; -.
DR PaxDb; P90917; -.
DR PeptideAtlas; P90917; -.
DR EnsemblMetazoa; K07A1.11.1; K07A1.11.1; WBGene00004312.
DR GeneID; 172801; -.
DR KEGG; cel:CELE_K07A1.11; -.
DR UCSC; K07A1.11; c. elegans.
DR CTD; 172801; -.
DR WormBase; K07A1.11; CE11860; WBGene00004312; rba-1.
DR eggNOG; KOG0264; Eukaryota.
DR GeneTree; ENSGT00940000154748; -.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; P90917; -.
DR OMA; MSWSNTR; -.
DR OrthoDB; 831322at2759; -.
DR PhylomeDB; P90917; -.
DR Reactome; R-CEL-212300; PRC2 methylates histones and DNA.
DR Reactome; R-CEL-2559580; Oxidative Stress Induced Senescence.
DR Reactome; R-CEL-3214815; HDACs deacetylate histones.
DR Reactome; R-CEL-3214847; HATs acetylate histones.
DR Reactome; R-CEL-3214858; RMTs methylate histone arginines.
DR Reactome; R-CEL-8943724; Regulation of PTEN gene transcription.
DR Reactome; R-CEL-8951664; Neddylation.
DR PRO; PR:P90917; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00004312; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0035098; C:ESC/E(Z) complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016581; C:NuRD complex; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0001708; P:cell fate specification; IMP:WormBase.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0045138; P:nematode male tail tip morphogenesis; IMP:WormBase.
DR GO; GO:0050767; P:regulation of neurogenesis; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Developmental protein; Nucleus; Reference proteome;
KW Repeat; Repressor; Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..412
FT /note="Probable histone-binding protein rba-1"
FT /id="PRO_0000051184"
FT REPEAT 117..157
FT /note="WD 1"
FT REPEAT 169..209
FT /note="WD 2"
FT REPEAT 219..259
FT /note="WD 3"
FT REPEAT 262..302
FT /note="WD 4"
FT REPEAT 306..346
FT /note="WD 5"
FT REPEAT 365..405
FT /note="WD 6"
SQ SEQUENCE 412 AA; 46691 MW; 7F65FA7F4F2D7772 CRC64;
MSEAESCEET SKEHRIWKKN VPYLYDTVVT KEVEWPSLSV QWMPDVTKTE NSDSSMHRMI
HGTHTCGGVQ NHLMISKFTI TTDTPEFDDA KWDSEREEFG GYGEGSAAKW DTEIKINHPG
EVHRARYMPH NPFIIASRGP SDDVYIFDYT KHPSEPKDTK FRPQLRLKGH EGEGYGMSWS
NTREGHLLTA GDDGMICHWD INANQTISGQ IVPQSKFKGH SSNAEDVSFH ALHNFVFGSV
GDDRKLNLWD LRQSKPQLTA VGHTAEVNCI TFNPFSEYIL ATGSVDKTVA LWDMRNMRKK
MYTLKHHNDE IFQVSFSPHY ETVLASSGSD DRVIVWDISK IQDPSSSSAA SSDSVPPEVI
FIHAGHTGKV ADFSWNPNRP WTICSSDEFN ALQVWEVSNS LVSSEKWETE MI
