RBBD_DICDI
ID RBBD_DICDI Reviewed; 423 AA.
AC Q54SD4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Probable histone-binding protein rbbD;
GN Name=rbbD; ORFNames=DDB_G0282529;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC assembly factors, chromatin remodeling factors and histone deacetylases
CC to their histone substrates in a manner that is regulated by
CC nucleosomal DNA. Component of several complexes which regulate
CC chromatin metabolism (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Probably binds directly to helix 1 of the histone fold of
CC histone H4, a region that is not accessible when H4 is in chromatin.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000047; EAL66124.1; -; Genomic_DNA.
DR RefSeq; XP_640105.1; XM_635013.1.
DR AlphaFoldDB; Q54SD4; -.
DR SMR; Q54SD4; -.
DR STRING; 44689.DDB0232003; -.
DR PaxDb; Q54SD4; -.
DR PRIDE; Q54SD4; -.
DR EnsemblProtists; EAL66124; EAL66124; DDB_G0282529.
DR GeneID; 8623636; -.
DR KEGG; ddi:DDB_G0282529; -.
DR dictyBase; DDB_G0282529; rbbD.
DR eggNOG; KOG0264; Eukaryota.
DR HOGENOM; CLU_020445_3_1_1; -.
DR InParanoid; Q54SD4; -.
DR OMA; PHEEGCL; -.
DR PhylomeDB; Q54SD4; -.
DR Reactome; R-DDI-3214815; HDACs deacetylate histones.
DR Reactome; R-DDI-3214847; HATs acetylate histones.
DR Reactome; R-DDI-3214858; RMTs methylate histone arginines.
DR Reactome; R-DDI-8951664; Neddylation.
DR PRO; PR:Q54SD4; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0046689; P:response to mercury ion; IDA:dictyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator; DNA replication; Nucleus; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..423
FT /note="Probable histone-binding protein rbbD"
FT /id="PRO_0000328136"
FT REPEAT 119..159
FT /note="WD 1"
FT REPEAT 172..212
FT /note="WD 2"
FT REPEAT 222..262
FT /note="WD 3"
FT REPEAT 266..306
FT /note="WD 4"
FT REPEAT 310..350
FT /note="WD 5"
FT REPEAT 367..407
FT /note="WD 6"
SQ SEQUENCE 423 AA; 47731 MW; 0D0F0A0BB356276D CRC64;
MTTQMEDVEE KVINEEYKIW KRHTPFLYDM VITHALEWPS LTVAWLPVKT SQPNKPYSIE
KVILGTHTSD EEQNYLMVAK VHLPVDEASI ESLKYDDTKG EVGGIGNVSE KIEIIQKINH
EGEVNRARVM PQNHSIIATK TVSSEVYIFD TTKHPLEPTP DGKCSPNLKL TGHKKEGYGI
SWNPRKEGHL LSCSDDQSIC MWDISAASKS DSTLDALNIY NGHTSIVEDV AWHYIHDTFF
GSVGDDKKLM IWDTRTGTKP IHVVEAHNSE VNCLSFNPFC EFLVATGSTD KTVALWDMRN
LGNRLHSLIS HTDEVFQVQF SPHNETVLAS CGSDRRVNVW DLSRIGEEQN NEDAADGPPE
LLFIHGGHTS KISDFSWNPN DPWSIASVAE DNILQIWQMA ENIYNDREDD LENSKVTNAQ
IGE
