RBBE_DICDI
ID RBBE_DICDI Reviewed; 525 AA.
AC Q54MH6;
DT 04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Retinoblastoma-binding-like protein E;
GN Name=rbbE {ECO:0000312|dictyBase:DDB_G0285847};
GN ORFNames=DDB0191415 {ECO:0000312|dictyBase:DDB_G0285847};
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Involved in mono-, di- and trimethylation at 'Lys-4' of
CC histone H3. Histone H3 'Lys-4' methylation represents a specific tag
CC for epigenetic transcriptional activation.
CC {ECO:0000250|UniProtKB:Q15291}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15291}.
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DR EMBL; AAFI02000082; EAL64458.1; -; Genomic_DNA.
DR RefSeq; XP_638014.1; XM_632922.1.
DR AlphaFoldDB; Q54MH6; -.
DR SMR; Q54MH6; -.
DR STRING; 44689.DDB0191415; -.
DR PaxDb; Q54MH6; -.
DR EnsemblProtists; EAL64458; EAL64458; DDB_G0285847.
DR GeneID; 8625365; -.
DR KEGG; ddi:DDB_G0285847; -.
DR dictyBase; DDB_G0285847; rbbE.
DR eggNOG; KOG1273; Eukaryota.
DR HOGENOM; CLU_032142_2_2_1; -.
DR InParanoid; Q54MH6; -.
DR OMA; DYEDDIM; -.
DR PhylomeDB; Q54MH6; -.
DR Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR Reactome; R-DDI-8951664; Neddylation.
DR PRO; PR:Q54MH6; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR024977; Apc4_WD40_dom.
DR InterPro; IPR037850; RBBP5/Swd1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44040; PTHR44040; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..525
FT /note="Retinoblastoma-binding-like protein E"
FT /id="PRO_0000431812"
FT REPEAT 25..66
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 69..108
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 222..261
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 267..312
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 313..352
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REGION 371..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 59899 MW; 5A79CFB33B4658C3 CRC64;
MNLCLIDPFK QSDVPETVEY YLVDPKNIKS NCASFNRRGT LLAVGCASPI GKILVWDFDT
KKIVRTLYHH TGCVNSISWS RNGKKLLTAS NDGSLVLWDL ATSKILYSLE LESPILFAEF
HPRNNDLCLI VLQKGTDPIL LNFKSSEKTP LNIKSLVTSY IKREENSTGV IPTSVNSNYN
GVATFASFNR RGEKIFFGDS CGMISVLDFK SMTIDRQFKV ASSNTTVKQI EFSRNHRFML
VSSSDKVLRL ISLESTNLYQ QMREYQDSVN RMHWKKCCFS SNNEYVVGGM NHKSIHSIFI
WSVSGSLVKD LEGPKEGLVD VVWHPLRPII VSISFTGVIY VWTAYFEENW SSFAPDFQEL
EENLDYVEDE DEFDAKDSDN ENQEVNNNNN NNIGRNPYKK IKTQQELNDK NSEEEEFVDV
DHNDRITEFS SDEEEDLFCF SAIDDRYVSN VKFDDPRHPL YEKYQKDKED SSSTTSNSTI
SSSSSPSPSS SSTTTTTTTS QKKDETQKKE KSTKKERNSD SKKRK
