RBBP4_CHICK
ID RBBP4_CHICK Reviewed; 425 AA.
AC Q9W7I5;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Histone-binding protein RBBP4;
DE AltName: Full=Chromatin assembly factor 1 subunit C;
DE Short=CAF-1 subunit C;
DE AltName: Full=Chromatin assembly factor I p48 subunit;
DE Short=CAF-I 48 kDa subunit;
DE Short=CAF-I p48;
DE Short=chCAF-1 p48;
DE AltName: Full=Retinoblastoma-binding protein 4;
DE Short=RBBP-4;
DE AltName: Full=Retinoblastoma-binding protein p48;
GN Name=RBBP4; Synonyms=RBAP48;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH HDAC1; HDAC2 AND HDAC3.
RX PubMed=10347232; DOI=10.1074/jbc.274.23.16646;
RA Ahmad A., Takami Y., Nakayama T.;
RT "WD repeats of the p48 subunit of chicken chromatin assembly factor-1
RT required for in vitro interaction with chicken histone deacetylase-2.";
RL J. Biol. Chem. 274:16646-16653(1999).
RN [2]
RP INTERACTION WITH HAT1 AND HISTONE H4.
RX PubMed=11112423; DOI=10.1006/bbrc.2000.3874;
RA Ahmad A., Takami Y., Nakayama T.;
RT "Distinct regions of the chicken p46 polypeptide are required for its in
RT vitro interaction with histones H2B and H4 and histone acetyltransferase-
RT 1.";
RL Biochem. Biophys. Res. Commun. 279:95-102(2000).
RN [3]
RP INTERACTION WITH HAT1.
RX PubMed=11160883; DOI=10.1093/nar/29.3.629;
RA Ahmad A., Nagamatsu N., Kouriki H., Takami Y., Nakayama T.;
RT "Leucine zipper motif of chicken histone acetyltransferase-1 is essential
RT for in vivo and in vitro interactions with the p48 subunit of chicken
RT chromatin assembly factor-1.";
RL Nucleic Acids Res. 29:629-637(2001).
RN [4]
RP INTERACTION WITH HIRA.
RX PubMed=15527972; DOI=10.1016/j.gene.2004.07.031;
RA Ahmad A., Takami Y., Nakayama T.;
RT "WD dipeptide motifs and LXXLL motif of chicken HIRA are essential for
RT interactions with the p48 subunit of chromatin assembly factor-1 and
RT histone deacetylase-2 in vitro and in vivo.";
RL Gene 342:125-136(2004).
RN [5]
RP INTERACTION WITH CHAF1A.
RX PubMed=17065558; DOI=10.1091/mbc.e06-05-0426;
RA Takami Y., Ono T., Fukagawa T., Shibahara K., Nakayama T.;
RT "Essential role of chromatin assembly factor-1-mediated rapid nucleosome
RT assembly for DNA replication and cell division in vertebrate cells.";
RL Mol. Biol. Cell 18:129-141(2007).
CC -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC assembly factors, chromatin remodeling factors and histone deacetylases
CC to their histone substrates in a manner that is regulated by
CC nucleosomal DNA. {ECO:0000250}.
CC -!- SUBUNIT: Component of the DREAM complex (By similarity). Binds directly
CC to histone H4, probably via helix 1 of the histone fold, a region that
CC is not accessible when histone H4 is in chromatin (PubMed:11112423).
CC Interacts with CHAF1A, HDAC1, HDAC2, HDAC3 and HIRA (PubMed:10347232,
CC PubMed:15527972, PubMed:17065558). May also interact with HAT1
CC (PubMed:11112423, PubMed:11160883). {ECO:0000250|UniProtKB:Q09028,
CC ECO:0000269|PubMed:10347232, ECO:0000269|PubMed:11112423,
CC ECO:0000269|PubMed:11160883, ECO:0000269|PubMed:15527972,
CC ECO:0000269|PubMed:17065558}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09028}.
CC Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}.
CC -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC {ECO:0000305}.
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DR EMBL; AF097750; AAD40568.1; -; mRNA.
DR RefSeq; NP_990183.1; NM_204852.1.
DR AlphaFoldDB; Q9W7I5; -.
DR SMR; Q9W7I5; -.
DR BioGRID; 675936; 1.
DR STRING; 9031.ENSGALP00000005565; -.
DR PaxDb; Q9W7I5; -.
DR GeneID; 395658; -.
DR KEGG; gga:395658; -.
DR CTD; 5928; -.
DR VEuPathDB; HostDB:geneid_395658; -.
DR eggNOG; KOG0264; Eukaryota.
DR InParanoid; Q9W7I5; -.
DR OrthoDB; 831322at2759; -.
DR PhylomeDB; Q9W7I5; -.
DR PRO; PR:Q9W7I5; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:HGNC-UCL.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR GO; GO:0006338; P:chromatin remodeling; ISS:HGNC-UCL.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR022052; Histone-bd_RBBP4_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF12265; CAF1C_H4-bd; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cell cycle; Chromatin regulator; Chromosome; DNA replication;
KW Nucleus; Reference proteome; Repeat; Repressor; Telomere; Transcription;
KW Transcription regulation; WD repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..425
FT /note="Histone-binding protein RBBP4"
FT /id="PRO_0000051189"
FT REPEAT 122..155
FT /note="WD 1"
FT REPEAT 175..206
FT /note="WD 2"
FT REPEAT 225..256
FT /note="WD 3"
FT REPEAT 271..302
FT /note="WD 4"
FT REPEAT 315..346
FT /note="WD 5"
FT REPEAT 372..403
FT /note="WD 6"
FT REGION 361..406
FT /note="Interaction with HAT1"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 425 AA; 47607 MW; AFA97D55A444C360 CRC64;
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPEGKD
FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK
INHEGEVNRA RYMPQNPCII ATKTPSSDVL VFDYTKHPSK PDPSGECNPD LRLRGHQKEG
YGLSWNPNLS GHLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE
SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE
DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENINN DEDPEGSVDP
EGQGS
