ID   RBBP4_XENTR             Reviewed;         425 AA.
AC   Q5M7K4;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Histone-binding protein RBBP4;
DE   AltName: Full=Retinoblastoma-binding protein 4;
DE            Short=RBBP-4;
GN   Name=rbbp4;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC       assembly factors, chromatin remodeling factors and histone deacetylases
CC       to their histone substrates in a manner that is regulated by
CC       nucleosomal DNA. {ECO:0000250|UniProtKB:O93377}.
CC   -!- SUBUNIT: Component of the DREAM complex (By similarity). Binds directly
CC       to histone H4, probably via helix 1 of the histone fold, a region that
CC       is not accessible when histone H4 is in chromatin (By similarity).
CC       Forms a large corepressor complex that contains ncor1, sin3a and
CC       possibly sin3b, histone deacetylases hdac2, hdac1, rbbp4 and possibly
CC       rbbp7 (By similarity). {ECO:0000250|UniProtKB:O93377,
CC       ECO:0000250|UniProtKB:Q09028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09028}.
CC       Chromosome, telomere {ECO:0000250|UniProtKB:Q09028}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; BC088588; AAH88588.1; -; mRNA.
DR   AlphaFoldDB; Q5M7K4; -.
DR   SMR; Q5M7K4; -.
DR   InParanoid; Q5M7K4; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0033186; C:CAF-1 complex; ISS:UniProtKB.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016581; C:NuRD complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0031497; P:chromatin assembly; ISS:UniProtKB.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cell cycle; Chromatin regulator; Chromosome; DNA replication;
KW   Nucleus; Reference proteome; Repeat; Repressor; Telomere; Transcription;
KW   Transcription regulation; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..425
FT                   /note="Histone-binding protein RBBP4"
FT                   /id="PRO_0000051192"
FT   REPEAT          122..162
FT                   /note="WD 1"
FT   REPEAT          175..215
FT                   /note="WD 2"
FT   REPEAT          225..265
FT                   /note="WD 3"
FT   REPEAT          271..311
FT                   /note="WD 4"
FT   REPEAT          315..355
FT                   /note="WD 5"
FT   REPEAT          372..412
FT                   /note="WD 6"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   425 AA;  47623 MW;  A0AF7C2EB7D0D391 CRC64;
     MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL PDVTRPDGKD
     FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS EKGEFGGFGS VSGKIEIEIK
     INHEGEVNRA RYMPQNPCII ATKTPSSDVL VFDYTKHPSK PDPSGECNPD LRLRGHQKEG
     YGLSWNPNLS GNLLSASDDH TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE
     SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
     WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSPEDAE
     DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEDTEGGVDP
     EGQSS