RBBP5_DROME
ID RBBP5_DROME Reviewed; 489 AA.
AC Q9VPH8; B3DMX7;
DT 11-JUN-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Retinoblastoma-binding protein 5 homolog {ECO:0000250|UniProtKB:Q15291};
GN Name=Rbbp5 {ECO:0000312|EMBL:AAF51573.2, ECO:0000312|FlyBase:FBgn0036973};
GN ORFNames=CG5585;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF51573.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|EMBL:AAF51573.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL48742.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000312|EMBL:ACD81773.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305}
RP FUNCTION, IDENTIFICATION IN THE SET1 COMPLEX, AND SUBCELLULAR LOCATION.
RX PubMed=21694722; DOI=10.1038/emboj.2011.194;
RA Ardehali M.B., Mei A., Zobeck K.L., Caron M., Lis J.T., Kusch T.;
RT "Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with
RT role in transcription.";
RL EMBO J. 30:2817-2828(2011).
RN [6] {ECO:0000305}
RP FUNCTION, AND IDENTIFICATION IN THE SET1 AND MLL3/4 COMPLEXES.
RX PubMed=21875999; DOI=10.1128/mcb.06092-11;
RA Mohan M., Herz H.M., Smith E.R., Zhang Y., Jackson J., Washburn M.P.,
RA Florens L., Eissenberg J.C., Shilatifard A.;
RT "The COMPASS family of H3K4 methylases in Drosophila.";
RL Mol. Cell. Biol. 31:4310-4318(2011).
CC -!- FUNCTION: Component of the SET1 complex that specifically di- and
CC trimethylates 'Lys-4' of histone H3 and of the MLL3/4 complex which
CC also methylates histone H3 'Lys-4'. {ECO:0000269|PubMed:21694722,
CC ECO:0000269|PubMed:21875999}.
CC -!- SUBUNIT: Core component of several methyltransferase-containing
CC complexes. Component of the SET1 complex, composed at least of the
CC catalytic subunit Set1, wds/WDR5, Wdr82, Rbbp5, ash2, Cfp1/CXXC1, hcf
CC and Dpy-30L1. Component of the MLL3/4 complex composed at least of the
CC catalytic subunit trr, ash2, Rbbp5, Dpy-30L1, wds, hcf, ptip, Pa1, Utx,
CC Lpt and Ncoa6. {ECO:0000269|PubMed:21694722,
CC ECO:0000269|PubMed:21875999}.
CC -!- INTERACTION:
CC Q9VPH8; Q94545: ash2; NbExp=3; IntAct=EBI-163110, EBI-6991562;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21694722}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ACD81779.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014296; AAF51573.2; -; Genomic_DNA.
DR EMBL; AY071120; AAL48742.1; -; mRNA.
DR EMBL; BT032759; ACD81773.1; -; mRNA.
DR EMBL; BT032765; ACD81779.1; ALT_FRAME; mRNA.
DR RefSeq; NP_649209.1; NM_140952.3.
DR AlphaFoldDB; Q9VPH8; -.
DR SMR; Q9VPH8; -.
DR BioGRID; 65500; 5.
DR IntAct; Q9VPH8; 2.
DR MINT; Q9VPH8; -.
DR STRING; 7227.FBpp0077900; -.
DR PaxDb; Q9VPH8; -.
DR PRIDE; Q9VPH8; -.
DR DNASU; 40239; -.
DR EnsemblMetazoa; FBtr0078242; FBpp0077900; FBgn0036973.
DR GeneID; 40239; -.
DR KEGG; dme:Dmel_CG5585; -.
DR UCSC; CG5585-RA; d. melanogaster.
DR CTD; 5929; -.
DR FlyBase; FBgn0036973; Rbbp5.
DR VEuPathDB; VectorBase:FBgn0036973; -.
DR eggNOG; KOG1273; Eukaryota.
DR GeneTree; ENSGT00530000064100; -.
DR HOGENOM; CLU_032142_2_2_1; -.
DR InParanoid; Q9VPH8; -.
DR OMA; DYEDDIM; -.
DR OrthoDB; 1001705at2759; -.
DR PhylomeDB; Q9VPH8; -.
DR Reactome; R-DME-201722; Formation of the beta-catenin:TCF transactivating complex.
DR Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-DME-8951664; Neddylation.
DR BioGRID-ORCS; 40239; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 40239; -.
DR PRO; PR:Q9VPH8; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036973; Expressed in eye disc (Drosophila) and 42 other tissues.
DR Genevisible; Q9VPH8; DM.
DR GO; GO:0044665; C:MLL1/2 complex; ISS:FlyBase.
DR GO; GO:0044666; C:MLL3/4 complex; IDA:FlyBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IDA:FlyBase.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051568; P:histone H3-K4 methylation; IDA:FlyBase.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR037850; RBBP5/Swd1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR PANTHER; PTHR44040; PTHR44040; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..489
FT /note="Retinoblastoma-binding protein 5 homolog"
FT /id="PRO_0000429381"
FT REPEAT 22..63
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 64..103
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 147..187
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 195..234
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 248..290
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 292..330
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REGION 451..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 489 AA; 54406 MW; E959B7F5AA053858 CRC64;
MNLELLESFG QNYPEEFDGS LDCISLAVTC AFNKYGTLLA VGCNDGRIVI WDFLTRGIAK
IISAHVHPVC SLSWTRNGHK LLSASTDNNV CIWDVLTGEL EHKYRFPSPV LKVQFDPRND
NRLLVCPMRY AAVLVEVGGT HRCLPLDSDG DLNIVASFDR RGKHIYTGNA KGKILVLDVE
TFEVVASFRI IVGTSSATAV KSIEFARRGD AFLINTSDRV IRVYDSKEII TLGKDGEPEP
IQKLQDLVNK TTWKKCCFSG DGEYICAGSA RQHALYIWEK SIGNLVKILH GTKGELLLDV
VWHPVRPIIA SISSGLVSIW AQNQVENWSA FAPDFKELDE NVEYEERESE FDIADEDKSV
DLNADAQQDE EIEVDVQKVE PVAAFCSSDE EGEDENALQF LPMAPEVEDP EDGWTGQDGL
EPSAVMLGHM EPHDYEDDIM ASKRRRMQLY DVSLPDAPTD ETHPLISSKA SKDKQQPVGG
KKAAGRTKK
