ID   RBBP7_CHICK             Reviewed;         424 AA.
AC   Q9I8G9;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Histone-binding protein RBBP7;
DE   AltName: Full=Retinoblastoma-binding protein 7;
DE            Short=RBBP-7;
DE   AltName: Full=Retinoblastoma-binding protein p46;
GN   Name=RBBP7; Synonyms=RBAP46;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH H2B; H4 AND HAT1.
RX   PubMed=11112423; DOI=10.1006/bbrc.2000.3874;
RA   Ahmad A., Takami Y., Nakayama T.;
RT   "Distinct regions of the chicken p46 polypeptide are required for its in
RT   vitro interaction with histones H2B and H4 and histone acetyltransferase-
RT   1.";
RL   Biochem. Biophys. Res. Commun. 279:95-102(2000).
CC   -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC       remodeling factors, histone acetyltransferases and histone deacetylases
CC       to their histone substrates in a manner that is regulated by
CC       nucleosomal DNA. {ECO:0000250}.
CC   -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC       region that is not accessible when H4 is in chromatin. Also interacts
CC       with histone H2B and HAT1. {ECO:0000269|PubMed:11112423}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; AF279275; AAF87775.1; -; mRNA.
DR   PIR; JC7558; JC7558.
DR   RefSeq; NP_990001.1; NM_204670.1.
DR   AlphaFoldDB; Q9I8G9; -.
DR   SMR; Q9I8G9; -.
DR   STRING; 9031.ENSGALP00000026647; -.
DR   PaxDb; Q9I8G9; -.
DR   GeneID; 395390; -.
DR   KEGG; gga:395390; -.
DR   CTD; 5931; -.
DR   VEuPathDB; HostDB:geneid_395390; -.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q9I8G9; -.
DR   OrthoDB; 831322at2759; -.
DR   PhylomeDB; Q9I8G9; -.
DR   TreeFam; TF106485; -.
DR   PRO; PR:Q9I8G9; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:AgBase.
DR   GO; GO:0016581; C:NuRD complex; ISS:AgBase.
DR   GO; GO:0016589; C:NURF complex; IEA:Ensembl.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR   GO; GO:0070370; P:cellular heat acclimation; IEA:Ensembl.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:AgBase.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:AgBase.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Chromatin regulator; DNA replication; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..424
FT                   /note="Histone-binding protein RBBP7"
FT                   /id="PRO_0000223246"
FT   REPEAT          47..121
FT                   /note="WD 1"
FT   REPEAT          127..172
FT                   /note="WD 2"
FT   REPEAT          180..216
FT                   /note="WD 3"
FT   REPEAT          227..268
FT                   /note="WD 4"
FT   REPEAT          274..311
FT                   /note="WD 5"
FT   REPEAT          317..368
FT                   /note="WD 6"
FT   REPEAT          375..402
FT                   /note="WD 7"
FT   REGION          359..404
FT                   /note="Interaction with HAT1"
FT                   /evidence="ECO:0000269|PubMed:11112423"
SQ   SEQUENCE   424 AA;  47703 MW;  92AC0838465307CE CRC64;
     MASKEVLEDT VEERVISEEY KIWKKNTPFL YDLVMTHALE WPSLTVQWLP DVSRPEGKDY
     ALHWLVLGTH TSDEQNHLVV ARVQIPNDDQ FDTSQYDSEK GEFGGFGSVT GKIETEIKIN
     HEGEVNRARY MPQNPYIIAT KTPSADVLVF DYTKHPSKPD PSGECNPDLR LRGHQKEGYG
     LSWNSNLKGH LLSASDDHTV CLWDISAGPK EGKIVDAKAI FTGHSAVVED VAWHLLHESL
     FGSVADDQKL MIWDTRSNTT SKPSHSVDAH TAEVNCLSFN PYSEFILATG SADKTVALWD
     LRNLKLKLHS FESHKDEIFQ VHWSPHNETI LASSGTDRRL NVWDLSKIGE EQSAEDAEDG
     PPELLFIHGG HTAKISDFSW NPNEPWVICS VSEDNIMQIW QMAENIYNDE EPDIAAAELE
     GQGT