ID   RBBP7_DANRE             Reviewed;         426 AA.
AC   Q7ZTY4; Q6NWL5;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Histone-binding protein RBBP7;
DE   AltName: Full=Retinoblastoma-binding protein 7;
DE            Short=RBBP-7;
GN   Name=rbbp7; Synonyms=rbb4l;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC       remodeling factors, histone acetyltransferases and histone deacetylases
CC       to their histone substrates in a manner that is regulated by
CC       nucleosomal DNA. {ECO:0000250}.
CC   -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC       region that is not accessible when H4 is in chromatin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH67546.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BC052110; AAH52110.1; -; mRNA.
DR   EMBL; BC067546; AAH67546.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_997775.1; NM_212610.1.
DR   AlphaFoldDB; Q7ZTY4; -.
DR   SMR; Q7ZTY4; -.
DR   STRING; 7955.ENSDARP00000025096; -.
DR   PaxDb; Q7ZTY4; -.
DR   GeneID; 322129; -.
DR   KEGG; dre:322129; -.
DR   CTD; 322129; -.
DR   ZFIN; ZDB-GENE-030131-848; rbb4l.
DR   eggNOG; KOG0264; Eukaryota.
DR   InParanoid; Q7ZTY4; -.
DR   OrthoDB; 831322at2759; -.
DR   PhylomeDB; Q7ZTY4; -.
DR   Reactome; R-DRE-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-DRE-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-DRE-3214815; HDACs deacetylate histones.
DR   Reactome; R-DRE-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-DRE-3214858; RMTs methylate histone arginines.
DR   Reactome; R-DRE-606279; Deposition of new CENPA-containing nucleosomes at the centromere.
DR   Reactome; R-DRE-6804758; Regulation of TP53 Activity through Acetylation.
DR   Reactome; R-DRE-73762; RNA Polymerase I Transcription Initiation.
DR   Reactome; R-DRE-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-DRE-8951664; Neddylation.
DR   Reactome; R-DRE-8953750; Transcriptional Regulation by E2F6.
DR   PRO; PR:Q7ZTY4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016581; C:NuRD complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0031101; P:fin regeneration; IGI:ZFIN.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:ZFIN.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Chromatin regulator; DNA replication; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..426
FT                   /note="Histone-binding protein RBBP7"
FT                   /id="PRO_0000223247"
FT   REPEAT          47..123
FT                   /note="WD 1"
FT   REPEAT          129..174
FT                   /note="WD 2"
FT   REPEAT          182..218
FT                   /note="WD 3"
FT   REPEAT          229..270
FT                   /note="WD 4"
FT   REPEAT          276..313
FT                   /note="WD 5"
FT   REPEAT          319..370
FT                   /note="WD 6"
FT   REPEAT          377..404
FT                   /note="WD 7"
FT   CONFLICT        83
FT                   /note="A -> V (in Ref. 1; AAH67546)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        151
FT                   /note="A -> V (in Ref. 1; AAH67546)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   426 AA;  47752 MW;  4ACBD320FBB6DA90 CRC64;
     MADKEVYDDA VEERVINEEY KIWKKNTPFL YDLVMTHALE WPSLTVQWLP DVNRPEGKDY
     VVHRLVLGTH TSDEQNHLVI ASAQIPNDDA QFDASHYDSE KGAEFGGFGS VSGKIEIEIK
     INHEGEVNRA RYMPQNPCII ATKTPTSDVL AFDYTKHPSK PDPSGDCSPD LRLRGHQKEG
     YGLSWNPNLS GNLLSASDDH TICLWDISGA PKEGKIVDAK TIFTGHTAVV EDVSWHLLHE
     SLFGSVADDQ KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
     WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI GEEQSAEDAE
     DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ VWQMAENIYN DEEPDTPASE
     LEGQAS