ID   RBBP7_XENLA             Reviewed;         425 AA.
AC   Q8AVH1;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Histone-binding protein RBBP7;
DE   AltName: Full=Retinoblastoma-binding protein 7;
DE            Short=RBBP-7;
GN   Name=rbbp7;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC       remodeling factors, histone acetyltransferases and histone deacetylases
CC       to their histone substrates in a manner that is regulated by
CC       nucleosomal DNA. {ECO:0000250}.
CC   -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC       region that is not accessible when H4 is in chromatin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; BC042283; AAH42283.1; -; mRNA.
DR   RefSeq; XP_018102361.1; XM_018246872.1.
DR   AlphaFoldDB; Q8AVH1; -.
DR   SMR; Q8AVH1; -.
DR   BioGRID; 98298; 1.
DR   GeneID; 108708306; -.
DR   KEGG; xla:108708306; -.
DR   Xenbase; XB-GENE-487913; rbbp7.L.
DR   OMA; PITDFNW; -.
DR   OrthoDB; 831322at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 108708306; Expressed in ovary and 19 other tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Chromatin regulator; DNA replication; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..425
FT                   /note="Histone-binding protein RBBP7"
FT                   /id="PRO_0000223248"
FT   REPEAT          47..122
FT                   /note="WD 1"
FT   REPEAT          128..173
FT                   /note="WD 2"
FT   REPEAT          181..217
FT                   /note="WD 3"
FT   REPEAT          228..269
FT                   /note="WD 4"
FT   REPEAT          275..312
FT                   /note="WD 5"
FT   REPEAT          318..369
FT                   /note="WD 6"
FT   REPEAT          376..403
FT                   /note="WD 7"
SQ   SEQUENCE   425 AA;  47745 MW;  DC151F18868C3956 CRC64;
     MANKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALE WPSLTVQWLP DVTRPEGKDY
     ALHWLVLGTH TSDEQNHLVV ARVQVPNDDA QFDASHYDSE KGEFGGFGSV SGKIETEIKI
     NHEGEVNRAR YMPQNPCIIA TKTPSADVLV FDYTKHPSKP DPSGECSPDL RLRGHQKEGY
     GLSWNSNLSG HLLSASDDHT VCLWDISAGP KEGKVVDAKA VFTGHSAVVE DVAWHLLHES
     LFGSVADDQK LMIWDTRSNT TSKPSHSVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW
     DLRNLKLKLH SFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED
     GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EEPDIPASEL
     EAQGS