ID   RBBP7_XENTR             Reviewed;         425 AA.
AC   Q6P315;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Histone-binding protein RBBP7;
DE   AltName: Full=Retinoblastoma-binding protein 7;
DE            Short=RBBP-7;
GN   Name=rbbp7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core histone-binding subunit that may target chromatin
CC       remodeling factors, histone acetyltransferases and histone deacetylases
CC       to their histone substrates in a manner that is regulated by
CC       nucleosomal DNA. {ECO:0000250}.
CC   -!- SUBUNIT: Binds directly to helix 1 of the histone fold of histone H4, a
CC       region that is not accessible when H4 is in chromatin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
CC       {ECO:0000305}.
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DR   EMBL; BC064219; AAH64219.1; -; mRNA.
DR   RefSeq; NP_989285.1; NM_203954.1.
DR   AlphaFoldDB; Q6P315; -.
DR   SMR; Q6P315; -.
DR   STRING; 8364.ENSXETP00000002157; -.
DR   PaxDb; Q6P315; -.
DR   DNASU; 394900; -.
DR   Ensembl; ENSXETT00000002157; ENSXETP00000002157; ENSXETG00000026983.
DR   GeneID; 394900; -.
DR   KEGG; xtr:394900; -.
DR   CTD; 5931; -.
DR   Xenbase; XB-GENE-487909; rbbp7.
DR   eggNOG; KOG0264; Eukaryota.
DR   HOGENOM; CLU_020445_3_1_1; -.
DR   InParanoid; Q6P315; -.
DR   OMA; PITDFNW; -.
DR   OrthoDB; 831322at2759; -.
DR   PhylomeDB; Q6P315; -.
DR   TreeFam; TF106485; -.
DR   Reactome; R-XTR-212300; PRC2 methylates histones and DNA.
DR   Reactome; R-XTR-2559580; Oxidative Stress Induced Senescence.
DR   Reactome; R-XTR-3214815; HDACs deacetylate histones.
DR   Reactome; R-XTR-3214841; PKMTs methylate histone lysines.
DR   Reactome; R-XTR-3214847; HATs acetylate histones.
DR   Reactome; R-XTR-3214858; RMTs methylate histone arginines.
DR   Reactome; R-XTR-8943724; Regulation of PTEN gene transcription.
DR   Reactome; R-XTR-8951664; Neddylation.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000026983; Expressed in ovary and 18 other tissues.
DR   GO; GO:0035098; C:ESC/E(Z) complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0016581; C:NuRD complex; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 5.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 5.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Chromatin regulator; DNA replication; Nucleus;
KW   Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; WD repeat.
FT   CHAIN           1..425
FT                   /note="Histone-binding protein RBBP7"
FT                   /id="PRO_0000223249"
FT   REPEAT          47..122
FT                   /note="WD 1"
FT   REPEAT          128..173
FT                   /note="WD 2"
FT   REPEAT          181..217
FT                   /note="WD 3"
FT   REPEAT          228..269
FT                   /note="WD 4"
FT   REPEAT          275..312
FT                   /note="WD 5"
FT   REPEAT          318..369
FT                   /note="WD 6"
FT   REPEAT          376..403
FT                   /note="WD 7"
SQ   SEQUENCE   425 AA;  47759 MW;  4A3F7F0435AC4F61 CRC64;
     MANKEMFEDT VEERVINEEY KIWKKNTPFL YDLVMTHALE WPSLTVQWLP DVTRPEGKDY
     ALHWLVLGTH TSDEQNHLVV ARVQIPNDDA QFDASHYDSE KGEFGGFGSV SGKIETEIKI
     NHEGEVNRAR YMPQNPCIIA TKTPSADVLV FDYTKHPSKP DPSGDCSPDL RLRGHQKEGY
     GLSWNSNLSG HLLSASDDHT VCLWDISAGP KEGKVVDAKA IFTGHSAVVE DVAWHLLHES
     LFGSVADDQK LMIWDTRSNT TSKPSHSVDA HTAEVNCLSF NPYSEFILAT GSADKTVALW
     DLRNLKLKLH SFESHKDEIF QVHWSPHNET ILASSGTDRR LNVWDLSKIG EEQSAEDAED
     GPPELLFIHG GHTAKISDFS WNPNEPWVIC SVSEDNIMQI WQMAENIYND EEPDIPASEL
     EAQGS