RBF1_CANAL
ID RBF1_CANAL Reviewed; 534 AA.
AC Q5ABZ2; A0A1D8PQ02; Q5ACB3;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Transcription factor RBF1;
DE AltName: Full=RPG-box-binding factor 1;
GN Name=RBF1; OrderedLocusNames=CAALFM_C602840CA;
GN ORFNames=CaO19.13004, CaO19.5558;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION, SUBCELLULAR LOCATION, AND DNA-BINDING.
RX PubMed=9043119; DOI=10.1099/00221287-143-2-417;
RA Ishii N., Yamamoto M., Lahm H.-W., Iizumi S., Yoshihara F., Nakayama H.,
RA Arisawa M., Aoki Y.;
RT "A DNA-binding protein from Candida albicans that binds to the RPG box of
RT Saccharomyces cerevisiae and the telomeric repeat sequence of C.
RT albicans.";
RL Microbiology 143:417-427(1997).
RN [5]
RP DNA-BINDING, FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=9043120; DOI=10.1099/00221287-143-2-429;
RA Ishii N., Yamamoto M., Yoshihara F., Arisawa M., Aoki Y.;
RT "Biochemical and genetic characterization of Rbf1p, a putative
RT transcription factor of Candida albicans.";
RL Microbiology 143:429-435(1997).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=10464197; DOI=10.1128/jb.181.17.5273-5279.1999;
RA Sharkey L.L., McNemar M.D., Saporito-Irwin S.M., Sypherd P.S., Fonzi W.A.;
RT "HWP1 functions in the morphological development of Candida albicans
RT downstream of EFG1, TUP1, and RBF1.";
RL J. Bacteriol. 181:5273-5279(1999).
RN [7]
RP IDENTIFICATION AS AN IMMUNOGENIC ANTIGEN, AND INDUCTION.
RX PubMed=12787355; DOI=10.1046/j.1365-2958.2003.03521.x;
RA Cheng S., Clancy C.J., Checkley M.A., Handfield M., Hillman J.D.,
RA Progulske-Fox A., Lewin A.S., Fidel P.L., Nguyen M.H.;
RT "Identification of Candida albicans genes induced during thrush offers
RT insight into pathogenesis.";
RL Mol. Microbiol. 48:1275-1288(2003).
RN [8]
RP INDUCTION.
RX PubMed=16710830; DOI=10.1002/yea.1373;
RA Umeyama T., Kaneko A., Niimi M., Uehara Y.;
RT "Repression of CDC28 reduces the expression of the morphology-related
RT transcription factors, Efg1p, Nrg1p, Rbf1p, Rim101p, Fkh2p and Tec1p and
RT induces cell elongation in Candida albicans.";
RL Yeast 23:537-552(2006).
RN [9]
RP INDUCTION.
RX PubMed=18616606; DOI=10.1111/j.1567-1364.2008.00404.x;
RA Menon V., De Bernardis F., Calderone R., Chauhan N.;
RT "Transcriptional profiling of the Candida albicans Ssk1p receiver domain
RT point mutants and their virulence.";
RL FEMS Yeast Res. 8:756-763(2008).
RN [10]
RP INDUCTION.
RX PubMed=20388546; DOI=10.1016/j.fgb.2010.03.009;
RA Alonso-Monge R., Roman E., Arana D.M., Prieto D., Urrialde V., Nombela C.,
RA Pla J.;
RT "The Sko1 protein represses the yeast-to-hypha transition and regulates the
RT oxidative stress response in Candida albicans.";
RL Fungal Genet. Biol. 47:587-601(2010).
CC -!- FUNCTION: Transcriptional activator that binds to the RPG box and to
CC telomeres. Involved in the regulation of the transition between yeast
CC and filamentous forms and plays a role in virulence. Induces expression
CC of HWP1, a major hyphal cell protein and virulence factor.
CC {ECO:0000269|PubMed:10464197, ECO:0000269|PubMed:9043119,
CC ECO:0000269|PubMed:9043120}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9043119}. Chromosome,
CC telomere {ECO:0000269|PubMed:9043119}.
CC -!- INDUCTION: Expression is increased in during infection. Expression is
CC also regulated by CDC28, SKO1, and SSK1. {ECO:0000269|PubMed:12787355,
CC ECO:0000269|PubMed:16710830, ECO:0000269|PubMed:18616606,
CC ECO:0000269|PubMed:20388546}.
CC -!- DISRUPTION PHENOTYPE: Induces filamentous growth and leads to decreased
CC HWP1 expression. {ECO:0000269|PubMed:10464197,
CC ECO:0000269|PubMed:9043120}.
CC -!- SIMILARITY: Belongs to the RBF1 family. {ECO:0000305}.
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DR EMBL; CP017628; AOW30215.1; -; Genomic_DNA.
DR RefSeq; XP_719121.1; XM_714028.1.
DR AlphaFoldDB; Q5ABZ2; -.
DR STRING; 237561.Q5ABZ2; -.
DR GeneID; 3639251; -.
DR KEGG; cal:CAALFM_C602840CA; -.
DR CGD; CAL0000186291; RBF1.
DR VEuPathDB; FungiDB:C6_02840C_A; -.
DR eggNOG; ENOG502QQV3; Eukaryota.
DR HOGENOM; CLU_033822_0_0_1; -.
DR InParanoid; Q5ABZ2; -.
DR OMA; RCKIVIN; -.
DR OrthoDB; 1486013at2759; -.
DR PRO; PR:Q5ABZ2; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:CGD.
DR GO; GO:0005634; C:nucleus; IDA:CGD.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:CGD.
DR GO; GO:0042162; F:telomeric DNA binding; IDA:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:CGD.
PE 1: Evidence at protein level;
KW Activator; Chromosome; Coiled coil; DNA-binding; Nucleus;
KW Reference proteome; Telomere; Transcription; Transcription regulation;
KW Virulence.
FT CHAIN 1..534
FT /note="Transcription factor RBF1"
FT /id="PRO_0000425601"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 353..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..534
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..147
FT /evidence="ECO:0000255"
FT COILED 332..386
FT /evidence="ECO:0000255"
FT COMPBIAS 266..285
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 60280 MW; BA7AD268BDE052C8 CRC64;
MSSNKNQSDL NIPTNSASLK QKQRQQLGIK SEIGASTSDV YDPQVASYLS AGDSPSQFAN
TALHHSNSVS YSASAAAAAA ELQHRAELQR RQQQLQQQEL QHQQEQLQQY RQAQAQAQAQ
AQAQAQAQRE HQQLQHAYQQ QQQLHQLGQL SQQLAQPHLS QHEHVRDALT TDEFDTNEDL
RSRYIENEIV KTFNSKAELV HFVKNELGPE ERCKIVINSS KPKAVYFQCE RSGSFRTTVK
DATKRQRIAY TKRNKCAYRL VANLYPNEKD QKRKNKPDEP GHNEENSRIS EMWVLRMINP
QHNHAPDPIN KKKRQKTSRT LVEKPINKPH HHHLLQQEQQ QQQQQQQQQQ QQQQQQQQQQ
HNANSQAQQQ AAQLQQQMQQ QLQASGLPTT PNYSELLGQL GQLSQQQSQQ QQLHHIPQQR
QRTQSQQSQQ QPQQTPHGLD QPDAAVIAAI EASAAAAVAS QGSPNVTAAA VAALQHTQGN
EHDAQQQQDR GGNNGGAIDS NVDPSLDPNV DPNVQAHDHS HGLRNSYGKR SGFL
