AAEB_YERPE
ID AAEB_YERPE Reviewed; 651 AA.
AC Q8ZAU8; Q0WAW8; Q74PP1; Q7CL76;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545};
GN OrderedLocusNames=YPO3686, y0177, YP_3857;
OS Yersinia pestis.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Yersiniaceae; Yersinia.
OX NCBI_TaxID=632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CO-92 / Biovar Orientalis;
RX PubMed=11586360; DOI=10.1038/35097083;
RA Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA Stevens K., Whitehead S., Barrell B.G.;
RT "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL Nature 413:523-527(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIM10+ / Biovar Mediaevalis;
RX PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT "Genome sequence of Yersinia pestis KIM.";
RL J. Bacteriol. 184:4601-4611(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=91001 / Biovar Mediaevalis;
RX PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA Wang J., Huang P., Yang R.;
RT "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT avirulent to humans.";
RL DNA Res. 11:179-197(2004).
CC -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC relief valve, allowing to eliminate certain compounds when they
CC accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC Rule:MF_01545}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01545}.
CC -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR EMBL; AL590842; CAL22274.1; -; Genomic_DNA.
DR EMBL; AE009952; AAM83771.1; -; Genomic_DNA.
DR EMBL; AE017042; AAS64002.1; -; Genomic_DNA.
DR PIR; AG0448; AG0448.
DR RefSeq; WP_002210095.1; NZ_WUCM01000032.1.
DR RefSeq; YP_002348570.1; NC_003143.1.
DR AlphaFoldDB; Q8ZAU8; -.
DR STRING; 214092.YPO3686; -.
DR PaxDb; Q8ZAU8; -.
DR DNASU; 1145124; -.
DR EnsemblBacteria; AAM83771; AAM83771; y0177.
DR EnsemblBacteria; AAS64002; AAS64002; YP_3857.
DR GeneID; 66844035; -.
DR KEGG; ype:YPO3686; -.
DR KEGG; ypk:y0177; -.
DR KEGG; ypm:YP_3857; -.
DR PATRIC; fig|214092.21.peg.4193; -.
DR eggNOG; COG1289; Bacteria.
DR HOGENOM; CLU_027647_0_0_6; -.
DR OMA; MITQACE; -.
DR Proteomes; UP000000815; Chromosome.
DR Proteomes; UP000001019; Chromosome.
DR Proteomes; UP000002490; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR HAMAP; MF_01545; AaeB; 1.
DR InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR Pfam; PF04632; FUSC; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..651
FT /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT /id="PRO_0000210086"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 150..170
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 429..449
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 455..475
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT TRANSMEM 481..501
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
SQ SEQUENCE 651 AA; 72437 MW; 0A8BD1C2CFC0704F CRC64;
MTHPSFIRLR FAFKLSFAIV AALFLGFHLQ LETPRWSVLT AAIVSAGPAF AAGGEPFSGA
IRHRGWLRII GTFIGCIGGL VIIVLTIRAP VLTLMLCCLW AGICTWISSL VRVENSYAFG
LAGYTALIII VTTGETPLLT PQFAVERCSE IVLGIVCAVM ADLLFSPRSI KQDIDRLVDK
VLVDQYRLLQ LCIQPAEKSE IDRAWNELVK NTTSLNGMRS YLMMESSRWQ RCNRRLQVLH
TESLALITQA CETYLVMSNH PEVISAELKT MLSEPAQTPA EIHQQMKKLR QFIAASHSEA
IPHTISSWVG AATRYLLLSK GIQTNSSINQ VEEDILAGDA PVKPISAEGH HAMINGLRTG
IATAIGGLFW LWTGWTSGAG CMVMIAVVTS LAMRTPNPRR MALDFLVGVI IALPIGALYF
MFIIPSTQQS MLLLCISLGV LAFIIGIEVQ KRRLGSLGTL ASTINIIVLS NPMIFNVRQF
LDSALGQIVG CFVSLIVLLL IRDNAKDRTG RTLLNRFVYS AVSALTTNKT KRGENHLPAL
YQQLNQLLMM FPADIDKYRL ALTLIIAHQR LNRTEIPVNA ELSAFHKQIR STAERVITVN
NDQKRRYYFA RLLQELDQYQ QKLVDYQAAD AVIRPVKRLT EMLRKYQSAL I
