ID   AAEB_YERPS              Reviewed;         651 AA.
AC   Q665H2;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeB {ECO:0000255|HAMAP-Rule:MF_01545};
DE            Short=pHBA efflux pump protein B {ECO:0000255|HAMAP-Rule:MF_01545};
GN   Name=aaeB {ECO:0000255|HAMAP-Rule:MF_01545}; OrderedLocusNames=YPTB3546;
OS   Yersinia pseudotuberculosis serotype I (strain IP32953).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=273123;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IP32953;
RX   PubMed=15358858; DOI=10.1073/pnas.0404012101;
RA   Chain P.S.G., Carniel E., Larimer F.W., Lamerdin J., Stoutland P.O.,
RA   Regala W.M., Georgescu A.M., Vergez L.M., Land M.L., Motin V.L.,
RA   Brubaker R.R., Fowler J., Hinnebusch J., Marceau M., Medigue C.,
RA   Simonet M., Chenal-Francisque V., Souza B., Dacheux D., Elliott J.M.,
RA   Derbise A., Hauser L.J., Garcia E.;
RT   "Insights into the evolution of Yersinia pestis through whole-genome
RT   comparison with Yersinia pseudotuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:13826-13831(2004).
CC   -!- FUNCTION: Forms an efflux pump with AaeA. Could function as a metabolic
CC       relief valve, allowing to eliminate certain compounds when they
CC       accumulate to high levels in the cell. {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01545}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01545}.
CC   -!- SIMILARITY: Belongs to the aromatic acid exporter ArAE (TC 2.A.85)
CC       family. {ECO:0000255|HAMAP-Rule:MF_01545}.
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DR   EMBL; BX936398; CAH22784.1; -; Genomic_DNA.
DR   RefSeq; WP_002210095.1; NZ_CP009712.1.
DR   AlphaFoldDB; Q665H2; -.
DR   EnsemblBacteria; CAH22784; CAH22784; YPTB3546.
DR   GeneID; 66844035; -.
DR   KEGG; ypo:BZ17_3055; -.
DR   KEGG; yps:YPTB3546; -.
DR   PATRIC; fig|273123.14.peg.3201; -.
DR   OMA; MITQACE; -.
DR   Proteomes; UP000001011; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046942; P:carboxylic acid transport; IEA:InterPro.
DR   HAMAP; MF_01545; AaeB; 1.
DR   InterPro; IPR006726; PHBA_efflux_AaeB/fusaric-R.
DR   InterPro; IPR023706; PHBA_efflux_pump_AaeB.
DR   PANTHER; PTHR30509:SF10; PTHR30509:SF10; 1.
DR   Pfam; PF04632; FUSC; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..651
FT                   /note="p-hydroxybenzoic acid efflux pump subunit AaeB"
FT                   /id="PRO_0000210087"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        91..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        119..139
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        405..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        429..449
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
FT   TRANSMEM        481..501
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01545"
SQ   SEQUENCE   651 AA;  72437 MW;  0A8BD1C2CFC0704F CRC64;
     MTHPSFIRLR FAFKLSFAIV AALFLGFHLQ LETPRWSVLT AAIVSAGPAF AAGGEPFSGA
     IRHRGWLRII GTFIGCIGGL VIIVLTIRAP VLTLMLCCLW AGICTWISSL VRVENSYAFG
     LAGYTALIII VTTGETPLLT PQFAVERCSE IVLGIVCAVM ADLLFSPRSI KQDIDRLVDK
     VLVDQYRLLQ LCIQPAEKSE IDRAWNELVK NTTSLNGMRS YLMMESSRWQ RCNRRLQVLH
     TESLALITQA CETYLVMSNH PEVISAELKT MLSEPAQTPA EIHQQMKKLR QFIAASHSEA
     IPHTISSWVG AATRYLLLSK GIQTNSSINQ VEEDILAGDA PVKPISAEGH HAMINGLRTG
     IATAIGGLFW LWTGWTSGAG CMVMIAVVTS LAMRTPNPRR MALDFLVGVI IALPIGALYF
     MFIIPSTQQS MLLLCISLGV LAFIIGIEVQ KRRLGSLGTL ASTINIIVLS NPMIFNVRQF
     LDSALGQIVG CFVSLIVLLL IRDNAKDRTG RTLLNRFVYS AVSALTTNKT KRGENHLPAL
     YQQLNQLLMM FPADIDKYRL ALTLIIAHQR LNRTEIPVNA ELSAFHKQIR STAERVITVN
     NDQKRRYYFA RLLQELDQYQ QKLVDYQAAD AVIRPVKRLT EMLRKYQSAL I